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Intravitreal triamcinolone reinjection for refractory diabetic macular edema.

Ramezani A, Ahmadieh H, Tabatabaei H - Korean J Ophthalmol (2006)

Bottom Line: The changes were statistically analyzed using a paired t test and were compared to the results of the first injections.Two months after the first administration, intraocular pressure was found to be raised significantly (5.58 mmHg, P = 0.001).Korean

View Article: PubMed Central - PubMed

Affiliation: Ophthalmic Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. arramezani@gmail.com

ABSTRACT

Purpose: To evaluate the effect of intravitreal triamcinolone acetonide (IVT) reinjection on clinical and optical coherence tomographic features in refractory diabetic macular edema.

Methods: In a prospective interventional case series, all IVT treated patients enrolled in a previous clinical trial were recalled to have a new ophthalmologic examination and optical coherence tomography (OCT) performed. Eyes found suitable for reinjection received 4 mg IVT. Complete clinical examination and OCT were repeated at 2 and 4 months post-injection. The changes were statistically analyzed using a paired t test and were compared to the results of the first injections.

Results: Of all returning patients, 12 cases with complete records were considered candidates for reinjection. Visual acuity (VA) changes were not significant after the first and second interventions, although there was a relative improvement (0.14 logMAR) 2 months after the first injection. Reductions of central macular thickness (CMT) were 43 +/- 69 microm, and 40 +/- 69 microm after the first injection and 27 +/- 48 microm, 49 +/- 58 microm after the reinjection at 2 & 4 months, respectively. None of the mentioned changes was significant. After the second injection, however, intraocular pressure was elevated at both 2 & 4 months (3.6 & 2.4 mmHg respectively, P < 0.05). Two months after the first administration, intraocular pressure was found to be raised significantly (5.58 mmHg, P = 0.001).

Conclusions: The transient beneficial effects of IVT on diabetic macular edema are not repeated with second injections. However, IVT-related ocular hypertension is more persistent after reinjection. Korean

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Intraocular pressure changes after the first and the second njections.
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Figure 6: Intraocular pressure changes after the first and the second njections.

Mentions: Mean initial IOP before the second injection was higher than that of the first one (P=0.037). Table 5 indicates that IOP rise after the first intervention (5.58 mmHg) was greater than that following the reinjection (3.58 mmHg); however, it persisted longer after the repeated injection (Fig. 6). The IOP changes between months 2 and 4 were -4.75 and +0.66 mmHg after the first and the second injections, respectively, and showed significant difference (P=0.006).


Intravitreal triamcinolone reinjection for refractory diabetic macular edema.

Ramezani A, Ahmadieh H, Tabatabaei H - Korean J Ophthalmol (2006)

Intraocular pressure changes after the first and the second njections.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2908839&req=5

Figure 6: Intraocular pressure changes after the first and the second njections.
Mentions: Mean initial IOP before the second injection was higher than that of the first one (P=0.037). Table 5 indicates that IOP rise after the first intervention (5.58 mmHg) was greater than that following the reinjection (3.58 mmHg); however, it persisted longer after the repeated injection (Fig. 6). The IOP changes between months 2 and 4 were -4.75 and +0.66 mmHg after the first and the second injections, respectively, and showed significant difference (P=0.006).

Bottom Line: The changes were statistically analyzed using a paired t test and were compared to the results of the first injections.Two months after the first administration, intraocular pressure was found to be raised significantly (5.58 mmHg, P = 0.001).Korean

View Article: PubMed Central - PubMed

Affiliation: Ophthalmic Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. arramezani@gmail.com

ABSTRACT

Purpose: To evaluate the effect of intravitreal triamcinolone acetonide (IVT) reinjection on clinical and optical coherence tomographic features in refractory diabetic macular edema.

Methods: In a prospective interventional case series, all IVT treated patients enrolled in a previous clinical trial were recalled to have a new ophthalmologic examination and optical coherence tomography (OCT) performed. Eyes found suitable for reinjection received 4 mg IVT. Complete clinical examination and OCT were repeated at 2 and 4 months post-injection. The changes were statistically analyzed using a paired t test and were compared to the results of the first injections.

Results: Of all returning patients, 12 cases with complete records were considered candidates for reinjection. Visual acuity (VA) changes were not significant after the first and second interventions, although there was a relative improvement (0.14 logMAR) 2 months after the first injection. Reductions of central macular thickness (CMT) were 43 +/- 69 microm, and 40 +/- 69 microm after the first injection and 27 +/- 48 microm, 49 +/- 58 microm after the reinjection at 2 & 4 months, respectively. None of the mentioned changes was significant. After the second injection, however, intraocular pressure was elevated at both 2 & 4 months (3.6 & 2.4 mmHg respectively, P < 0.05). Two months after the first administration, intraocular pressure was found to be raised significantly (5.58 mmHg, P = 0.001).

Conclusions: The transient beneficial effects of IVT on diabetic macular edema are not repeated with second injections. However, IVT-related ocular hypertension is more persistent after reinjection. Korean

Show MeSH
Related in: MedlinePlus