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Intravitreal triamcinolone reinjection for refractory diabetic macular edema.

Ramezani A, Ahmadieh H, Tabatabaei H - Korean J Ophthalmol (2006)

Bottom Line: The changes were statistically analyzed using a paired t test and were compared to the results of the first injections.Two months after the first administration, intraocular pressure was found to be raised significantly (5.58 mmHg, P = 0.001).Korean

View Article: PubMed Central - PubMed

Affiliation: Ophthalmic Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. arramezani@gmail.com

ABSTRACT

Purpose: To evaluate the effect of intravitreal triamcinolone acetonide (IVT) reinjection on clinical and optical coherence tomographic features in refractory diabetic macular edema.

Methods: In a prospective interventional case series, all IVT treated patients enrolled in a previous clinical trial were recalled to have a new ophthalmologic examination and optical coherence tomography (OCT) performed. Eyes found suitable for reinjection received 4 mg IVT. Complete clinical examination and OCT were repeated at 2 and 4 months post-injection. The changes were statistically analyzed using a paired t test and were compared to the results of the first injections.

Results: Of all returning patients, 12 cases with complete records were considered candidates for reinjection. Visual acuity (VA) changes were not significant after the first and second interventions, although there was a relative improvement (0.14 logMAR) 2 months after the first injection. Reductions of central macular thickness (CMT) were 43 +/- 69 microm, and 40 +/- 69 microm after the first injection and 27 +/- 48 microm, 49 +/- 58 microm after the reinjection at 2 & 4 months, respectively. None of the mentioned changes was significant. After the second injection, however, intraocular pressure was elevated at both 2 & 4 months (3.6 & 2.4 mmHg respectively, P < 0.05). Two months after the first administration, intraocular pressure was found to be raised significantly (5.58 mmHg, P = 0.001).

Conclusions: The transient beneficial effects of IVT on diabetic macular edema are not repeated with second injections. However, IVT-related ocular hypertension is more persistent after reinjection. Korean

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Mean visual acuity (SD) before, 2, 4 and about 10 months after the first intravitreal triamcinolone injection.
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Figure 1: Mean visual acuity (SD) before, 2, 4 and about 10 months after the first intravitreal triamcinolone injection.

Mentions: The comparison of VA changes between the new exam and each previous one (at months 0, 2, and 4 after the first injection) were not statistically significant. Fig. 1 demonstrates that VA remained relatively stable during 10 months of follow up. However, a transient but statistically insignificant improvement occurred by 2 months after the injection.


Intravitreal triamcinolone reinjection for refractory diabetic macular edema.

Ramezani A, Ahmadieh H, Tabatabaei H - Korean J Ophthalmol (2006)

Mean visual acuity (SD) before, 2, 4 and about 10 months after the first intravitreal triamcinolone injection.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2908839&req=5

Figure 1: Mean visual acuity (SD) before, 2, 4 and about 10 months after the first intravitreal triamcinolone injection.
Mentions: The comparison of VA changes between the new exam and each previous one (at months 0, 2, and 4 after the first injection) were not statistically significant. Fig. 1 demonstrates that VA remained relatively stable during 10 months of follow up. However, a transient but statistically insignificant improvement occurred by 2 months after the injection.

Bottom Line: The changes were statistically analyzed using a paired t test and were compared to the results of the first injections.Two months after the first administration, intraocular pressure was found to be raised significantly (5.58 mmHg, P = 0.001).Korean

View Article: PubMed Central - PubMed

Affiliation: Ophthalmic Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. arramezani@gmail.com

ABSTRACT

Purpose: To evaluate the effect of intravitreal triamcinolone acetonide (IVT) reinjection on clinical and optical coherence tomographic features in refractory diabetic macular edema.

Methods: In a prospective interventional case series, all IVT treated patients enrolled in a previous clinical trial were recalled to have a new ophthalmologic examination and optical coherence tomography (OCT) performed. Eyes found suitable for reinjection received 4 mg IVT. Complete clinical examination and OCT were repeated at 2 and 4 months post-injection. The changes were statistically analyzed using a paired t test and were compared to the results of the first injections.

Results: Of all returning patients, 12 cases with complete records were considered candidates for reinjection. Visual acuity (VA) changes were not significant after the first and second interventions, although there was a relative improvement (0.14 logMAR) 2 months after the first injection. Reductions of central macular thickness (CMT) were 43 +/- 69 microm, and 40 +/- 69 microm after the first injection and 27 +/- 48 microm, 49 +/- 58 microm after the reinjection at 2 & 4 months, respectively. None of the mentioned changes was significant. After the second injection, however, intraocular pressure was elevated at both 2 & 4 months (3.6 & 2.4 mmHg respectively, P < 0.05). Two months after the first administration, intraocular pressure was found to be raised significantly (5.58 mmHg, P = 0.001).

Conclusions: The transient beneficial effects of IVT on diabetic macular edema are not repeated with second injections. However, IVT-related ocular hypertension is more persistent after reinjection. Korean

Show MeSH
Related in: MedlinePlus