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Comparison of retinal nerve fiber layer measurements between NTG and HTG using GDx-vCC.

Jung JI, Kim JH, Kook MS - Korean J Ophthalmol (2006)

Bottom Line: All thickness parameters were lower in HTG patients compared to NTG patients, but there were no significant differences in ratio parameters between age-matched early HTG and NTG patients.The sensitivity of GDx-VCC was significantly higher in both early and total HTG patients compared to the respective groups of NTG patients.Compared to eyes with NTG, eyes with HTG showed reduced RNFL thickness and ratio parameters when patients were age and visual field matched.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University of Soonchunhyang, College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To compare quantitative polarimetric measurements in eyes with NTG and HTG using GDx-VCC. Both groups were matched by age and glaucoma stage based on the Humphrey visual field test.

Methods: We retrospectively reviewed the records of 146 patients who underwent Humphrey field analysis (HFA) and GDx-VCC. We compared outcomes of retinal nerve fiber layer (RNFL) parameters among the three groups by ANOVA and between each pair of groups using the Tukey-Kramer Post-Hoc test. We also evaluated the sensitivity and specificity of GDx-VCC in detecting glaucoma in each group.

Results: The mean age and HFA mean deviation (MD) were 55.6 +/- 9.5 years and -0.8 +/- 1.5 dB in 47 control patients, 59.4 +/- 9.0 years and -5.77 +/- 4.38 dB in 49 NTG patients, and 59.4 +/- 11.7 years and -8.09 +/- 6.77 dB in 51 HTG patients, respectively. All thickness parameters were lower in HTG patients compared to NTG patients, but there were no significant differences in ratio parameters between age-matched early HTG and NTG patients. The sensitivity of GDx-VCC was significantly higher in both early and total HTG patients compared to the respective groups of NTG patients.

Conclusions: Compared to eyes with NTG, eyes with HTG showed reduced RNFL thickness and ratio parameters when patients were age and visual field matched. GDx-VCC appeared to be more sensitive in detecting RNFL damage in HTG patients.

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Related in: MedlinePlus

Comparison of ratio and modulation parameters in early stage NTG and HTG eyes (Humphrey visual field mean deviation >-6dB)INESYMM: intereye symmetry, SYMMETRY: symmetry, SUPRATIO: superior ratio, INFRATIO: inferior ratio, SUPNAS: superior/nasal ratio, MAXMOD: maximal modulation, ELLIMOD: ellipse modulation.*P<0.05 by Post Hoc Tukey-Kramer test.
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Figure 4: Comparison of ratio and modulation parameters in early stage NTG and HTG eyes (Humphrey visual field mean deviation >-6dB)INESYMM: intereye symmetry, SYMMETRY: symmetry, SUPRATIO: superior ratio, INFRATIO: inferior ratio, SUPNAS: superior/nasal ratio, MAXMOD: maximal modulation, ELLIMOD: ellipse modulation.*P<0.05 by Post Hoc Tukey-Kramer test.

Mentions: We also evaluated the same parameters for the early glaucoma patients (MD>-6 dB). Table 4 shows the demographic and clinical characteristics of patients with early stage glaucoma (MD>-6 dB). There were no differences among the three groups with respect to age, visual acuity, refractive error, or CCT. When we measured GDx-VCC parameters in the three groups of early stage glaucoma patients, we found that all parameters were significantly different except for symmetry (P<0.05 by one way ANOVA; Table 5). A comparison between the control group and the early stage NTG group showed that all thickness parameters (TSNIT average, superior average, inferior average, superior maximum, inferior maximum, and ellipse average) differed significantly (P<0.05 by Post Hoc Tukey-Kramer test), whereas none of the ratio parameters was significantly different. When we compared the control group with the early stage HTG group, we found that all parameters, except for symmetry, were significantly different (P<.05 by Post Hoc Tukey-Kramer test). Comparing the early stage NTG and early stage HTG groups, we found that all thickness (P<.05 by Post Hoc Tukey-Kramer test) (Fig. 3), but that there were no significant differences in any of the ratio parameters (Fig. 4).


Comparison of retinal nerve fiber layer measurements between NTG and HTG using GDx-vCC.

Jung JI, Kim JH, Kook MS - Korean J Ophthalmol (2006)

Comparison of ratio and modulation parameters in early stage NTG and HTG eyes (Humphrey visual field mean deviation >-6dB)INESYMM: intereye symmetry, SYMMETRY: symmetry, SUPRATIO: superior ratio, INFRATIO: inferior ratio, SUPNAS: superior/nasal ratio, MAXMOD: maximal modulation, ELLIMOD: ellipse modulation.*P<0.05 by Post Hoc Tukey-Kramer test.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2908813&req=5

Figure 4: Comparison of ratio and modulation parameters in early stage NTG and HTG eyes (Humphrey visual field mean deviation >-6dB)INESYMM: intereye symmetry, SYMMETRY: symmetry, SUPRATIO: superior ratio, INFRATIO: inferior ratio, SUPNAS: superior/nasal ratio, MAXMOD: maximal modulation, ELLIMOD: ellipse modulation.*P<0.05 by Post Hoc Tukey-Kramer test.
Mentions: We also evaluated the same parameters for the early glaucoma patients (MD>-6 dB). Table 4 shows the demographic and clinical characteristics of patients with early stage glaucoma (MD>-6 dB). There were no differences among the three groups with respect to age, visual acuity, refractive error, or CCT. When we measured GDx-VCC parameters in the three groups of early stage glaucoma patients, we found that all parameters were significantly different except for symmetry (P<0.05 by one way ANOVA; Table 5). A comparison between the control group and the early stage NTG group showed that all thickness parameters (TSNIT average, superior average, inferior average, superior maximum, inferior maximum, and ellipse average) differed significantly (P<0.05 by Post Hoc Tukey-Kramer test), whereas none of the ratio parameters was significantly different. When we compared the control group with the early stage HTG group, we found that all parameters, except for symmetry, were significantly different (P<.05 by Post Hoc Tukey-Kramer test). Comparing the early stage NTG and early stage HTG groups, we found that all thickness (P<.05 by Post Hoc Tukey-Kramer test) (Fig. 3), but that there were no significant differences in any of the ratio parameters (Fig. 4).

Bottom Line: All thickness parameters were lower in HTG patients compared to NTG patients, but there were no significant differences in ratio parameters between age-matched early HTG and NTG patients.The sensitivity of GDx-VCC was significantly higher in both early and total HTG patients compared to the respective groups of NTG patients.Compared to eyes with NTG, eyes with HTG showed reduced RNFL thickness and ratio parameters when patients were age and visual field matched.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University of Soonchunhyang, College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To compare quantitative polarimetric measurements in eyes with NTG and HTG using GDx-VCC. Both groups were matched by age and glaucoma stage based on the Humphrey visual field test.

Methods: We retrospectively reviewed the records of 146 patients who underwent Humphrey field analysis (HFA) and GDx-VCC. We compared outcomes of retinal nerve fiber layer (RNFL) parameters among the three groups by ANOVA and between each pair of groups using the Tukey-Kramer Post-Hoc test. We also evaluated the sensitivity and specificity of GDx-VCC in detecting glaucoma in each group.

Results: The mean age and HFA mean deviation (MD) were 55.6 +/- 9.5 years and -0.8 +/- 1.5 dB in 47 control patients, 59.4 +/- 9.0 years and -5.77 +/- 4.38 dB in 49 NTG patients, and 59.4 +/- 11.7 years and -8.09 +/- 6.77 dB in 51 HTG patients, respectively. All thickness parameters were lower in HTG patients compared to NTG patients, but there were no significant differences in ratio parameters between age-matched early HTG and NTG patients. The sensitivity of GDx-VCC was significantly higher in both early and total HTG patients compared to the respective groups of NTG patients.

Conclusions: Compared to eyes with NTG, eyes with HTG showed reduced RNFL thickness and ratio parameters when patients were age and visual field matched. GDx-VCC appeared to be more sensitive in detecting RNFL damage in HTG patients.

Show MeSH
Related in: MedlinePlus