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Comparison of retinal nerve fiber layer measurements between NTG and HTG using GDx-vCC.

Jung JI, Kim JH, Kook MS - Korean J Ophthalmol (2006)

Bottom Line: All thickness parameters were lower in HTG patients compared to NTG patients, but there were no significant differences in ratio parameters between age-matched early HTG and NTG patients.The sensitivity of GDx-VCC was significantly higher in both early and total HTG patients compared to the respective groups of NTG patients.Compared to eyes with NTG, eyes with HTG showed reduced RNFL thickness and ratio parameters when patients were age and visual field matched.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University of Soonchunhyang, College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To compare quantitative polarimetric measurements in eyes with NTG and HTG using GDx-VCC. Both groups were matched by age and glaucoma stage based on the Humphrey visual field test.

Methods: We retrospectively reviewed the records of 146 patients who underwent Humphrey field analysis (HFA) and GDx-VCC. We compared outcomes of retinal nerve fiber layer (RNFL) parameters among the three groups by ANOVA and between each pair of groups using the Tukey-Kramer Post-Hoc test. We also evaluated the sensitivity and specificity of GDx-VCC in detecting glaucoma in each group.

Results: The mean age and HFA mean deviation (MD) were 55.6 +/- 9.5 years and -0.8 +/- 1.5 dB in 47 control patients, 59.4 +/- 9.0 years and -5.77 +/- 4.38 dB in 49 NTG patients, and 59.4 +/- 11.7 years and -8.09 +/- 6.77 dB in 51 HTG patients, respectively. All thickness parameters were lower in HTG patients compared to NTG patients, but there were no significant differences in ratio parameters between age-matched early HTG and NTG patients. The sensitivity of GDx-VCC was significantly higher in both early and total HTG patients compared to the respective groups of NTG patients.

Conclusions: Compared to eyes with NTG, eyes with HTG showed reduced RNFL thickness and ratio parameters when patients were age and visual field matched. GDx-VCC appeared to be more sensitive in detecting RNFL damage in HTG patients.

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Ratio and modulation parameters in all NTG and HTG eyes.INESYMM: intereye symmetry, SYMMETRY: symmetry, SUPRATIO: superior ratio, INFRATIO: inferior ratio, SUPNAS: superior/nasal ratio, MAXMOD: maximal modulation, ELLIMOD: ellipse modulation, *P<0.05 by Post Hoc Tukey-Kramer test.
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Figure 2: Ratio and modulation parameters in all NTG and HTG eyes.INESYMM: intereye symmetry, SYMMETRY: symmetry, SUPRATIO: superior ratio, INFRATIO: inferior ratio, SUPNAS: superior/nasal ratio, MAXMOD: maximal modulation, ELLIMOD: ellipse modulation, *P<0.05 by Post Hoc Tukey-Kramer test.

Mentions: Table 2 shows the GDx-VCC parameters of the three groups. Except for symmetry, all parameters differed significantly among the three groups (P<0.05 by one way ANOVA). When we compared the control and NTG groups, we found that all thickness parameters (TSNIT average, superior average, inferior average, superior maximum, inferior maximum, and ellipse average) were significantly higher in the control group (P<0.05 by the Post Hoc Tukey-Kramer test), but the only significant differences in ratio parameters were the superior/nasal and inferior/nasal ratios. When we compared the control and HTG groups, all parameters except for symmetry were significantly higher in the control group (P<0.05 by Post Hoc Tukey-Kramer test). When we compared the NTG and HTG groups, all thickness parameters were significantly higher in the NTG group (P<0.05 by the Post Hoc Tukey-Kramer test) (Fig. 1), and the superior ratio, inferior ratio, superior/nasal ratio, maximal modulation, and ellipse modulation were significantly different (Fig. 2). The highest power parameter to discriminate between normal and glaucoma was NFI at a cutoff value of 27 (not shown). When we evaluated the sensitivity and specificity of NFI at a cutoff value 27 to detect HTG and NTG (Table 3), we found that its sensitivity for HTG was parameters were significantly higher in the NTG group significantly higher than for NTG (P<0.05 by Chi Square test).


Comparison of retinal nerve fiber layer measurements between NTG and HTG using GDx-vCC.

Jung JI, Kim JH, Kook MS - Korean J Ophthalmol (2006)

Ratio and modulation parameters in all NTG and HTG eyes.INESYMM: intereye symmetry, SYMMETRY: symmetry, SUPRATIO: superior ratio, INFRATIO: inferior ratio, SUPNAS: superior/nasal ratio, MAXMOD: maximal modulation, ELLIMOD: ellipse modulation, *P<0.05 by Post Hoc Tukey-Kramer test.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2908813&req=5

Figure 2: Ratio and modulation parameters in all NTG and HTG eyes.INESYMM: intereye symmetry, SYMMETRY: symmetry, SUPRATIO: superior ratio, INFRATIO: inferior ratio, SUPNAS: superior/nasal ratio, MAXMOD: maximal modulation, ELLIMOD: ellipse modulation, *P<0.05 by Post Hoc Tukey-Kramer test.
Mentions: Table 2 shows the GDx-VCC parameters of the three groups. Except for symmetry, all parameters differed significantly among the three groups (P<0.05 by one way ANOVA). When we compared the control and NTG groups, we found that all thickness parameters (TSNIT average, superior average, inferior average, superior maximum, inferior maximum, and ellipse average) were significantly higher in the control group (P<0.05 by the Post Hoc Tukey-Kramer test), but the only significant differences in ratio parameters were the superior/nasal and inferior/nasal ratios. When we compared the control and HTG groups, all parameters except for symmetry were significantly higher in the control group (P<0.05 by Post Hoc Tukey-Kramer test). When we compared the NTG and HTG groups, all thickness parameters were significantly higher in the NTG group (P<0.05 by the Post Hoc Tukey-Kramer test) (Fig. 1), and the superior ratio, inferior ratio, superior/nasal ratio, maximal modulation, and ellipse modulation were significantly different (Fig. 2). The highest power parameter to discriminate between normal and glaucoma was NFI at a cutoff value of 27 (not shown). When we evaluated the sensitivity and specificity of NFI at a cutoff value 27 to detect HTG and NTG (Table 3), we found that its sensitivity for HTG was parameters were significantly higher in the NTG group significantly higher than for NTG (P<0.05 by Chi Square test).

Bottom Line: All thickness parameters were lower in HTG patients compared to NTG patients, but there were no significant differences in ratio parameters between age-matched early HTG and NTG patients.The sensitivity of GDx-VCC was significantly higher in both early and total HTG patients compared to the respective groups of NTG patients.Compared to eyes with NTG, eyes with HTG showed reduced RNFL thickness and ratio parameters when patients were age and visual field matched.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University of Soonchunhyang, College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To compare quantitative polarimetric measurements in eyes with NTG and HTG using GDx-VCC. Both groups were matched by age and glaucoma stage based on the Humphrey visual field test.

Methods: We retrospectively reviewed the records of 146 patients who underwent Humphrey field analysis (HFA) and GDx-VCC. We compared outcomes of retinal nerve fiber layer (RNFL) parameters among the three groups by ANOVA and between each pair of groups using the Tukey-Kramer Post-Hoc test. We also evaluated the sensitivity and specificity of GDx-VCC in detecting glaucoma in each group.

Results: The mean age and HFA mean deviation (MD) were 55.6 +/- 9.5 years and -0.8 +/- 1.5 dB in 47 control patients, 59.4 +/- 9.0 years and -5.77 +/- 4.38 dB in 49 NTG patients, and 59.4 +/- 11.7 years and -8.09 +/- 6.77 dB in 51 HTG patients, respectively. All thickness parameters were lower in HTG patients compared to NTG patients, but there were no significant differences in ratio parameters between age-matched early HTG and NTG patients. The sensitivity of GDx-VCC was significantly higher in both early and total HTG patients compared to the respective groups of NTG patients.

Conclusions: Compared to eyes with NTG, eyes with HTG showed reduced RNFL thickness and ratio parameters when patients were age and visual field matched. GDx-VCC appeared to be more sensitive in detecting RNFL damage in HTG patients.

Show MeSH
Related in: MedlinePlus