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Wnt signal transduction pathway and apoptosis: a review.

Pećina-Slaus N - Cancer Cell Int. (2010)

Bottom Line: The association between the wnt signaling pathway and apoptosis has become more firmly established in the recent scientific literature.Many reports indicate that the wnt signaling pathway regulates apoptosis through a variety of mechanisms.The activity of wnt signaling according to specific cellular environment stimuli can either foster or restrain the processes of apoptosis.Wnt signaling regulates the early and late stages of apoptosis in both development and cellular injury in populations of neurons, endothelial cells, vascular smooth muscle cells and cardiomyocytes.In this review I draw attention to genes and proteins of the wnt signaling pathway involved in apoptosis and describe some of their functional effects.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Biology, School of Medicine, University of Zagreb, Salata 3, HR-10000 Zagreb, Croatia. nina@mef.hr.

ABSTRACT
The association between the wnt signaling pathway and apoptosis has become more firmly established in the recent scientific literature. Many reports indicate that the wnt signaling pathway regulates apoptosis through a variety of mechanisms.The activity of wnt signaling according to specific cellular environment stimuli can either foster or restrain the processes of apoptosis. Wnt signaling regulates the early and late stages of apoptosis in both development and cellular injury in populations of neurons, endothelial cells, vascular smooth muscle cells and cardiomyocytes.In this review I draw attention to genes and proteins of the wnt signaling pathway involved in apoptosis and describe some of their functional effects.

No MeSH data available.


Related in: MedlinePlus

The intrinsic pathway of apoptosis induction as implemented by mitochondria. This figure illustrates the role of mitochondria in apoptosis.
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Figure 2: The intrinsic pathway of apoptosis induction as implemented by mitochondria. This figure illustrates the role of mitochondria in apoptosis.

Mentions: The role of mitochondria in apoptosis is remarkable; they contain many pro-apoptotic signals of which the most important are: AIF (apoptosis inducing factor), Smac, DIABLO and definitely cytochrome C. Formation of specific mitochondrial membrane pores occurs through the action of apoptosis promoting members of the Bcl-2 protein family. These pores are called "permeability transition pores" (PT). Once the PT pores are formed, pro-apoptotic molecules - AIF, Smac, DIABLO and cytochrome C - exit the mitochondrion. The release of cytochrome C into the cytosol is especially significant event for the induction of apoptosis. Cytochrome C interacts with a protein called Apaf (the homologue of CED-4 in C. elegans), which in turns activates caspase-9 and later caspase-3. The multiprotein complex casposome (apoptosome) forms, conprising cytochrome C, Apaf-1, procaspase-9 and ATP [1] (Figure 2).


Wnt signal transduction pathway and apoptosis: a review.

Pećina-Slaus N - Cancer Cell Int. (2010)

The intrinsic pathway of apoptosis induction as implemented by mitochondria. This figure illustrates the role of mitochondria in apoptosis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2908610&req=5

Figure 2: The intrinsic pathway of apoptosis induction as implemented by mitochondria. This figure illustrates the role of mitochondria in apoptosis.
Mentions: The role of mitochondria in apoptosis is remarkable; they contain many pro-apoptotic signals of which the most important are: AIF (apoptosis inducing factor), Smac, DIABLO and definitely cytochrome C. Formation of specific mitochondrial membrane pores occurs through the action of apoptosis promoting members of the Bcl-2 protein family. These pores are called "permeability transition pores" (PT). Once the PT pores are formed, pro-apoptotic molecules - AIF, Smac, DIABLO and cytochrome C - exit the mitochondrion. The release of cytochrome C into the cytosol is especially significant event for the induction of apoptosis. Cytochrome C interacts with a protein called Apaf (the homologue of CED-4 in C. elegans), which in turns activates caspase-9 and later caspase-3. The multiprotein complex casposome (apoptosome) forms, conprising cytochrome C, Apaf-1, procaspase-9 and ATP [1] (Figure 2).

Bottom Line: The association between the wnt signaling pathway and apoptosis has become more firmly established in the recent scientific literature.Many reports indicate that the wnt signaling pathway regulates apoptosis through a variety of mechanisms.The activity of wnt signaling according to specific cellular environment stimuli can either foster or restrain the processes of apoptosis.Wnt signaling regulates the early and late stages of apoptosis in both development and cellular injury in populations of neurons, endothelial cells, vascular smooth muscle cells and cardiomyocytes.In this review I draw attention to genes and proteins of the wnt signaling pathway involved in apoptosis and describe some of their functional effects.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Biology, School of Medicine, University of Zagreb, Salata 3, HR-10000 Zagreb, Croatia. nina@mef.hr.

ABSTRACT
The association between the wnt signaling pathway and apoptosis has become more firmly established in the recent scientific literature. Many reports indicate that the wnt signaling pathway regulates apoptosis through a variety of mechanisms.The activity of wnt signaling according to specific cellular environment stimuli can either foster or restrain the processes of apoptosis. Wnt signaling regulates the early and late stages of apoptosis in both development and cellular injury in populations of neurons, endothelial cells, vascular smooth muscle cells and cardiomyocytes.In this review I draw attention to genes and proteins of the wnt signaling pathway involved in apoptosis and describe some of their functional effects.

No MeSH data available.


Related in: MedlinePlus