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Developmental toxicity of endocrine disrupters bisphenol A and vinclozolin in a terrestrial isopod.

Lemos MF, van Gestel CA, Soares AM - Arch. Environ. Contam. Toxicol. (2010)

Bottom Line: Both chemicals elicited developmental toxicity to P. scaber by causing overall decreased growth.Although the LC50 values for juvenile and adult survival were fairly similar, juvenile woodlice showed an increased chronic sensitivity to both chemicals, and female woodlice were most the sensitive to BPA.We recommend the use of adults, juveniles, female, and male woodlice, as well as a large range of toxicant concentrations, to provide valuable information regarding differential dose responses, effects, and threshold values for EDCs.

View Article: PubMed Central - PubMed

Affiliation: CESAM and Department of Biology, University of Aveiro, 3810-193, Aveiro, Portugal. mlemos@ua.pt

ABSTRACT
Studies of the effects of endocrine-disrupting compounds (EDCs) on invertebrates are still largely underrepresented. This work aims to fill this gap by assessing the effects of bisphenol A (BPA) and vinclozolin (Vz) on the terrestrial isopod Porcellio scaber (common rough woodlouse). Male adult and sexually undifferentiated juvenile woodlice were exposed to the toxicants. Effects on molting regime and growth were investigated independently for males and female woodlice after sexual differentiation. Both chemicals elicited developmental toxicity to P. scaber by causing overall decreased growth. Nevertheless, BPA induced molting, whereas Vz delayed it. Although the LC50 values for juvenile and adult survival were fairly similar, juvenile woodlice showed an increased chronic sensitivity to both chemicals, and female woodlice were most the sensitive to BPA. We recommend the use of adults, juveniles, female, and male woodlice, as well as a large range of toxicant concentrations, to provide valuable information regarding differential dose responses, effects, and threshold values for EDCs.

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Growth of juvenile P. scaber exposed for a 16-week period to soil treated with Vz (left graphs) or BPA (right graphs). a and c Mass gain (final weight/initial weight). b and d Size gain (final CW/initial CW). * Significant difference from the control at p ≤ 0.05 (ANOVA, Dunnett’s test)
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Fig5: Growth of juvenile P. scaber exposed for a 16-week period to soil treated with Vz (left graphs) or BPA (right graphs). a and c Mass gain (final weight/initial weight). b and d Size gain (final CW/initial CW). * Significant difference from the control at p ≤ 0.05 (ANOVA, Dunnett’s test)

Mentions: Juveniles’ size (CW) and mass gain were significantly impaired by Vz in both sexes (Fig. 5a, b). Size gain decreased with increasing toxicant concentrations and was significantly different at Vz concentration of 100 mg/kg soil compared with juvenile woodlice in nontreated soil (male and female woodlice with 14% and 16% reduction, respectively [ANOVA, Dunnett’s test, males: F5.80 = 2.647, p = 0.045 and females: F5.61 = 2.422, p = 0.045]). Juveniles’ weight gain also decreased with increasing concentrations of Vz, with significant differences compared with controls, at the highest concentration tested (100 mg a.i. Vz/kg soil) both for male and female woodlice (ANOVA, Dunnett’s test, F5.80 = 2.585, p = 0.036 and F5.61 = 2.565, p = 0.036, respectively).Fig. 5


Developmental toxicity of endocrine disrupters bisphenol A and vinclozolin in a terrestrial isopod.

Lemos MF, van Gestel CA, Soares AM - Arch. Environ. Contam. Toxicol. (2010)

Growth of juvenile P. scaber exposed for a 16-week period to soil treated with Vz (left graphs) or BPA (right graphs). a and c Mass gain (final weight/initial weight). b and d Size gain (final CW/initial CW). * Significant difference from the control at p ≤ 0.05 (ANOVA, Dunnett’s test)
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2908429&req=5

Fig5: Growth of juvenile P. scaber exposed for a 16-week period to soil treated with Vz (left graphs) or BPA (right graphs). a and c Mass gain (final weight/initial weight). b and d Size gain (final CW/initial CW). * Significant difference from the control at p ≤ 0.05 (ANOVA, Dunnett’s test)
Mentions: Juveniles’ size (CW) and mass gain were significantly impaired by Vz in both sexes (Fig. 5a, b). Size gain decreased with increasing toxicant concentrations and was significantly different at Vz concentration of 100 mg/kg soil compared with juvenile woodlice in nontreated soil (male and female woodlice with 14% and 16% reduction, respectively [ANOVA, Dunnett’s test, males: F5.80 = 2.647, p = 0.045 and females: F5.61 = 2.422, p = 0.045]). Juveniles’ weight gain also decreased with increasing concentrations of Vz, with significant differences compared with controls, at the highest concentration tested (100 mg a.i. Vz/kg soil) both for male and female woodlice (ANOVA, Dunnett’s test, F5.80 = 2.585, p = 0.036 and F5.61 = 2.565, p = 0.036, respectively).Fig. 5

Bottom Line: Both chemicals elicited developmental toxicity to P. scaber by causing overall decreased growth.Although the LC50 values for juvenile and adult survival were fairly similar, juvenile woodlice showed an increased chronic sensitivity to both chemicals, and female woodlice were most the sensitive to BPA.We recommend the use of adults, juveniles, female, and male woodlice, as well as a large range of toxicant concentrations, to provide valuable information regarding differential dose responses, effects, and threshold values for EDCs.

View Article: PubMed Central - PubMed

Affiliation: CESAM and Department of Biology, University of Aveiro, 3810-193, Aveiro, Portugal. mlemos@ua.pt

ABSTRACT
Studies of the effects of endocrine-disrupting compounds (EDCs) on invertebrates are still largely underrepresented. This work aims to fill this gap by assessing the effects of bisphenol A (BPA) and vinclozolin (Vz) on the terrestrial isopod Porcellio scaber (common rough woodlouse). Male adult and sexually undifferentiated juvenile woodlice were exposed to the toxicants. Effects on molting regime and growth were investigated independently for males and female woodlice after sexual differentiation. Both chemicals elicited developmental toxicity to P. scaber by causing overall decreased growth. Nevertheless, BPA induced molting, whereas Vz delayed it. Although the LC50 values for juvenile and adult survival were fairly similar, juvenile woodlice showed an increased chronic sensitivity to both chemicals, and female woodlice were most the sensitive to BPA. We recommend the use of adults, juveniles, female, and male woodlice, as well as a large range of toxicant concentrations, to provide valuable information regarding differential dose responses, effects, and threshold values for EDCs.

Show MeSH
Related in: MedlinePlus