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Radiation-induced meningeal osteosarcoma of tentorium cerebelli with intradural spinal metastases.

Ziewacz JE, Song JW, Blaivas M, Yang LJ - Surg Neurol Int (2010)

Bottom Line: Histopathologic analysis revealed chondroblastic osteosarcoma.The intracranial disease stabilized; however, multiple cervico-thoracic spinal metastases were discovered 15 months after initial diagnosis.The patient expired 16 months after initial diagnosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Neurosurgery, University of Michigan Health System, Ann Arbor, MI, USA.

ABSTRACT

Background: Primary meningeal osteosarcomas and radiation-induced extraosseous tumors are extremely rare. We encountered a patient with a radiation-induced meningeal osteosarcoma with metastatic spread.

Case description: A 54-year-old man presented with a 2-week history of nausea, vomiting, and ataxia. CT and MRI studies revealed an extra-axial, dural-based mass in the posterior fossa arising from the tentorium cerebelli. The patient underwent complete resection of the tumor with adjuvant chemotherapy. Histopathologic analysis revealed chondroblastic osteosarcoma. Tumor recurrence was observed 9 months after initial diagnosis, and adjuvant radiation therapy was administered. The intracranial disease stabilized; however, multiple cervico-thoracic spinal metastases were discovered 15 months after initial diagnosis. The patient expired 16 months after initial diagnosis.

Conclusion: Meningeal osteosarcomas are rare lesions that can metastasize and should be considered in the differential diagnosis for dural-based lesions, especially in the case of previous radiation therapy.

No MeSH data available.


Related in: MedlinePlus

Axial (left), sagittal (center), and coronal (right) T1-weighted MRIs with gadolinium enhancement illustrating extent of resection
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Figure 0002: Axial (left), sagittal (center), and coronal (right) T1-weighted MRIs with gadolinium enhancement illustrating extent of resection

Mentions: The patient underwent suboccipital craniotomy for resection of the mass with placement of a ventricular catheter. The procedure was uncomplicated, and the patient was discharged after a routine postoperative course.Although he continued to experience some mild left upper extremity dysmetria, his nausea, vomiting, and ataxia improved. Postoperative MRI revealed no obvious evidence of residual disease [Figure 2].


Radiation-induced meningeal osteosarcoma of tentorium cerebelli with intradural spinal metastases.

Ziewacz JE, Song JW, Blaivas M, Yang LJ - Surg Neurol Int (2010)

Axial (left), sagittal (center), and coronal (right) T1-weighted MRIs with gadolinium enhancement illustrating extent of resection
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2908355&req=5

Figure 0002: Axial (left), sagittal (center), and coronal (right) T1-weighted MRIs with gadolinium enhancement illustrating extent of resection
Mentions: The patient underwent suboccipital craniotomy for resection of the mass with placement of a ventricular catheter. The procedure was uncomplicated, and the patient was discharged after a routine postoperative course.Although he continued to experience some mild left upper extremity dysmetria, his nausea, vomiting, and ataxia improved. Postoperative MRI revealed no obvious evidence of residual disease [Figure 2].

Bottom Line: Histopathologic analysis revealed chondroblastic osteosarcoma.The intracranial disease stabilized; however, multiple cervico-thoracic spinal metastases were discovered 15 months after initial diagnosis.The patient expired 16 months after initial diagnosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Neurosurgery, University of Michigan Health System, Ann Arbor, MI, USA.

ABSTRACT

Background: Primary meningeal osteosarcomas and radiation-induced extraosseous tumors are extremely rare. We encountered a patient with a radiation-induced meningeal osteosarcoma with metastatic spread.

Case description: A 54-year-old man presented with a 2-week history of nausea, vomiting, and ataxia. CT and MRI studies revealed an extra-axial, dural-based mass in the posterior fossa arising from the tentorium cerebelli. The patient underwent complete resection of the tumor with adjuvant chemotherapy. Histopathologic analysis revealed chondroblastic osteosarcoma. Tumor recurrence was observed 9 months after initial diagnosis, and adjuvant radiation therapy was administered. The intracranial disease stabilized; however, multiple cervico-thoracic spinal metastases were discovered 15 months after initial diagnosis. The patient expired 16 months after initial diagnosis.

Conclusion: Meningeal osteosarcomas are rare lesions that can metastasize and should be considered in the differential diagnosis for dural-based lesions, especially in the case of previous radiation therapy.

No MeSH data available.


Related in: MedlinePlus