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Orbital manifestations of Langerhans Cell Histiocytosis: A report of three cases.

Das JK, Soibam R, Tiwary BK, Magdalene D, Paul SB, Bhuyan C - Oman J Ophthalmol (2009)

Bottom Line: Langerhans Cell Histiocytosis (LCH) is a spectrum of disorders characterized by accumulation of histiocytes in various tissues.It is rarely encountered in ophthalmic practice and has an affinity for the orbit.We report three patients with LCH involving the lateral orbital wall, each with a different form of the condition.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Sri Sankaradeva Nethralaya, Guwahati.

ABSTRACT
Langerhans Cell Histiocytosis (LCH) is a spectrum of disorders characterized by accumulation of histiocytes in various tissues. It is rarely encountered in ophthalmic practice and has an affinity for the orbit. We report three patients with LCH involving the lateral orbital wall, each with a different form of the condition.

No MeSH data available.


Related in: MedlinePlus

Patient 3 – Histopathologic picture on high magnification showing numerous histiocytes and eosinophils
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Figure 0006: Patient 3 – Histopathologic picture on high magnification showing numerous histiocytes and eosinophils

Mentions: Histopathological examination of biopsy of the cutaneous lesion [Figure 6] confirmed the diagnosis of LCH. This diagnosis was further consolidated by the S-100 protein and adenosine triphosphatase antibody tests. The patient was treated with by 12 cycles of chemotherapy (vinblastine 6 mg/m2) along with systemic corticosteroid (prednisolone). Following chemotherapy the periocular swelling subsided with reduction of cystic bony changes. The patient has been followed up for last five years without any recurrence.


Orbital manifestations of Langerhans Cell Histiocytosis: A report of three cases.

Das JK, Soibam R, Tiwary BK, Magdalene D, Paul SB, Bhuyan C - Oman J Ophthalmol (2009)

Patient 3 – Histopathologic picture on high magnification showing numerous histiocytes and eosinophils
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2903920&req=5

Figure 0006: Patient 3 – Histopathologic picture on high magnification showing numerous histiocytes and eosinophils
Mentions: Histopathological examination of biopsy of the cutaneous lesion [Figure 6] confirmed the diagnosis of LCH. This diagnosis was further consolidated by the S-100 protein and adenosine triphosphatase antibody tests. The patient was treated with by 12 cycles of chemotherapy (vinblastine 6 mg/m2) along with systemic corticosteroid (prednisolone). Following chemotherapy the periocular swelling subsided with reduction of cystic bony changes. The patient has been followed up for last five years without any recurrence.

Bottom Line: Langerhans Cell Histiocytosis (LCH) is a spectrum of disorders characterized by accumulation of histiocytes in various tissues.It is rarely encountered in ophthalmic practice and has an affinity for the orbit.We report three patients with LCH involving the lateral orbital wall, each with a different form of the condition.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Sri Sankaradeva Nethralaya, Guwahati.

ABSTRACT
Langerhans Cell Histiocytosis (LCH) is a spectrum of disorders characterized by accumulation of histiocytes in various tissues. It is rarely encountered in ophthalmic practice and has an affinity for the orbit. We report three patients with LCH involving the lateral orbital wall, each with a different form of the condition.

No MeSH data available.


Related in: MedlinePlus