Limits...
Combined autologous and allograft limbal cell transplantation with penetrating keratoplasty in a case of chemical corneal burn patient.

Mitra S - Oman J Ophthalmol (2009)

Bottom Line: The autologous and allograft limbal tissue included peripheral cornea, limbus and conjunctiva obtained from contralateral eye and cadaveric eye bank cornea.Central corneal button was used for a PKP with 32 intermittent sutures.Eighteen sutures are still in place; no vascularization has extended beyond the host graft junction.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Al-Zahra Private Hospital, Sharjah, UAE.

ABSTRACT
A patient with chemical corneal burn presented two months after the acute episode of chemical injury to his right eye (OD) and was diagnosed with severe limbal stem cell deficiency and with vascularized corneal opacity OD. Limbal cell transplantation and penetrating keratoplasty (PKP) was performed. The autologous and allograft limbal tissue included peripheral cornea, limbus and conjunctiva obtained from contralateral eye and cadaveric eye bank cornea. Central corneal button was used for a PKP with 32 intermittent sutures. One year after the procedure, the corneal surface remains clear with a best corrected visual acuity of 6/12 (-2.00 DS / -2.75 DC-/ 150°. Eighteen sutures are still in place; no vascularization has extended beyond the host graft junction. Ocular surface is wetting well with no filamentary keratitis.Combined autologous and allograft limbal cell transplant can be performed for severe deficiency of corneal stem cells in a patient with chemical corneal burn.

No MeSH data available.


Related in: MedlinePlus

Preoperative photograph of the eye of the patient with alkali burn showing superficial and deep corneal vascularization (single white arrow) with central corneal edema and opacity (double white arrows).
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Figure 0001: Preoperative photograph of the eye of the patient with alkali burn showing superficial and deep corneal vascularization (single white arrow) with central corneal edema and opacity (double white arrows).

Mentions: Ophthalmic examination revealed an unaided vision of 6/60 OD with no further improvement with refraction. There was narrowing of the palpebral aperture with fornix cicatrization. Slit lamp examination revealed bulbar and ciliary congestion, 360° superficial and deep corneal vascularization with vessels extending 4–5 mm from the limbus into the center of the cornea [Figures 1 and 2]. The central cornea was thickened with epithelial and stromal edema. Fluorescein staining revealed central epithelial defect of 2 mm. Pupil reacted well to both direct and consensual light stimulation and lens appeared clear. There was patchy iris atrophy and intraocular pressure (IOP) was recorded at 20 mm Hg with a Tonopen. Dilated fundus examination revealed normal optic disc, macula and retinal background. Schirmer′s test type I and II was abnormal and tear break-up time (BUT) was reduced.


Combined autologous and allograft limbal cell transplantation with penetrating keratoplasty in a case of chemical corneal burn patient.

Mitra S - Oman J Ophthalmol (2009)

Preoperative photograph of the eye of the patient with alkali burn showing superficial and deep corneal vascularization (single white arrow) with central corneal edema and opacity (double white arrows).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2903917&req=5

Figure 0001: Preoperative photograph of the eye of the patient with alkali burn showing superficial and deep corneal vascularization (single white arrow) with central corneal edema and opacity (double white arrows).
Mentions: Ophthalmic examination revealed an unaided vision of 6/60 OD with no further improvement with refraction. There was narrowing of the palpebral aperture with fornix cicatrization. Slit lamp examination revealed bulbar and ciliary congestion, 360° superficial and deep corneal vascularization with vessels extending 4–5 mm from the limbus into the center of the cornea [Figures 1 and 2]. The central cornea was thickened with epithelial and stromal edema. Fluorescein staining revealed central epithelial defect of 2 mm. Pupil reacted well to both direct and consensual light stimulation and lens appeared clear. There was patchy iris atrophy and intraocular pressure (IOP) was recorded at 20 mm Hg with a Tonopen. Dilated fundus examination revealed normal optic disc, macula and retinal background. Schirmer′s test type I and II was abnormal and tear break-up time (BUT) was reduced.

Bottom Line: The autologous and allograft limbal tissue included peripheral cornea, limbus and conjunctiva obtained from contralateral eye and cadaveric eye bank cornea.Central corneal button was used for a PKP with 32 intermittent sutures.Eighteen sutures are still in place; no vascularization has extended beyond the host graft junction.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Al-Zahra Private Hospital, Sharjah, UAE.

ABSTRACT
A patient with chemical corneal burn presented two months after the acute episode of chemical injury to his right eye (OD) and was diagnosed with severe limbal stem cell deficiency and with vascularized corneal opacity OD. Limbal cell transplantation and penetrating keratoplasty (PKP) was performed. The autologous and allograft limbal tissue included peripheral cornea, limbus and conjunctiva obtained from contralateral eye and cadaveric eye bank cornea. Central corneal button was used for a PKP with 32 intermittent sutures. One year after the procedure, the corneal surface remains clear with a best corrected visual acuity of 6/12 (-2.00 DS / -2.75 DC-/ 150°. Eighteen sutures are still in place; no vascularization has extended beyond the host graft junction. Ocular surface is wetting well with no filamentary keratitis.Combined autologous and allograft limbal cell transplant can be performed for severe deficiency of corneal stem cells in a patient with chemical corneal burn.

No MeSH data available.


Related in: MedlinePlus