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Cutaneous lesions of the nose.

Sand M, Sand D, Thrandorf C, Paech V, Altmeyer P, Bechara FG - Head Face Med (2010)

Bottom Line: Skin diseases on the nose are seen in a variety of medical disciplines.Dermatologists, otorhinolaryngologists, general practitioners and general plastic and dermatologic surgeons are regularly consulted regarding cutaneous lesions on the nose.This article is the second part of a review series dealing with cutaneous lesions on the head and face, which are frequently seen in daily practice by a dermatologic surgeon.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Dermatology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum, Gudrunstr 56, 44791 Bochum, Germany. michael.sand@ruhr-uni-bochum.de

ABSTRACT
Skin diseases on the nose are seen in a variety of medical disciplines. Dermatologists, otorhinolaryngologists, general practitioners and general plastic and dermatologic surgeons are regularly consulted regarding cutaneous lesions on the nose. This article is the second part of a review series dealing with cutaneous lesions on the head and face, which are frequently seen in daily practice by a dermatologic surgeon. In this review, we focus on those skin diseases on the nose where surgery or laser therapy is considered a possible treatment option or that can be surgically evaluated.

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Related in: MedlinePlus

Comedo. Multiple closed comedos at the nasolabial fold and the alar of the nose.
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Figure 1: Comedo. Multiple closed comedos at the nasolabial fold and the alar of the nose.

Mentions: Comedos are dilated sebaceous ducts consisting of hyper-proliferating ductal keratinocytes and sebum. They can be either open or closed. The nose with its sebaceous skin at the nasal tip and alae can frequently exhibit comedos [Fig 1]. Interleukin 1-alpha, which is present in 76% of open comedos, induces comedogenesis in vitro [12,13]. Furthermore, pilosebaceous ducts have androgen receptors, and estradiol treatment reduces comedos. Therefore, it has been proposed that androgens play a significant role in comedo formation [14,15]. A comedo reaction to different forms of irradiation (megavoltage, cobalt) has been described in the literature [16-20]. Changes in lipid composition of the sebum that lead to duct hyper-proliferation have been hypothesized as causative for this radio-oncologic phenomenon [21]. In addition to desquamation therapy with topical salicylic or retinoic acid, manual extraction by a cosmetician and physical removal by electrocautery or CO2 laser therapy have also been reported [22].


Cutaneous lesions of the nose.

Sand M, Sand D, Thrandorf C, Paech V, Altmeyer P, Bechara FG - Head Face Med (2010)

Comedo. Multiple closed comedos at the nasolabial fold and the alar of the nose.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2903548&req=5

Figure 1: Comedo. Multiple closed comedos at the nasolabial fold and the alar of the nose.
Mentions: Comedos are dilated sebaceous ducts consisting of hyper-proliferating ductal keratinocytes and sebum. They can be either open or closed. The nose with its sebaceous skin at the nasal tip and alae can frequently exhibit comedos [Fig 1]. Interleukin 1-alpha, which is present in 76% of open comedos, induces comedogenesis in vitro [12,13]. Furthermore, pilosebaceous ducts have androgen receptors, and estradiol treatment reduces comedos. Therefore, it has been proposed that androgens play a significant role in comedo formation [14,15]. A comedo reaction to different forms of irradiation (megavoltage, cobalt) has been described in the literature [16-20]. Changes in lipid composition of the sebum that lead to duct hyper-proliferation have been hypothesized as causative for this radio-oncologic phenomenon [21]. In addition to desquamation therapy with topical salicylic or retinoic acid, manual extraction by a cosmetician and physical removal by electrocautery or CO2 laser therapy have also been reported [22].

Bottom Line: Skin diseases on the nose are seen in a variety of medical disciplines.Dermatologists, otorhinolaryngologists, general practitioners and general plastic and dermatologic surgeons are regularly consulted regarding cutaneous lesions on the nose.This article is the second part of a review series dealing with cutaneous lesions on the head and face, which are frequently seen in daily practice by a dermatologic surgeon.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Dermatology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum, Gudrunstr 56, 44791 Bochum, Germany. michael.sand@ruhr-uni-bochum.de

ABSTRACT
Skin diseases on the nose are seen in a variety of medical disciplines. Dermatologists, otorhinolaryngologists, general practitioners and general plastic and dermatologic surgeons are regularly consulted regarding cutaneous lesions on the nose. This article is the second part of a review series dealing with cutaneous lesions on the head and face, which are frequently seen in daily practice by a dermatologic surgeon. In this review, we focus on those skin diseases on the nose where surgery or laser therapy is considered a possible treatment option or that can be surgically evaluated.

Show MeSH
Related in: MedlinePlus