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Ectopic primary type A thymoma located in two thoracic vertebras: a case report.

Marandino F, Zoccali C, Salducca N, Marino M, Visca P - BMC Cancer (2010)

Bottom Line: The immunohistochemical investigation for neuroectodermal, neuroendocrine, vascular and muscular markers were negative.It also confirmed the presence of CD3+, CD5+ T lymphocytes and the absence of immature T-lymphocyte markers.The case described shows a thymic hystogenesis for spindle cell tumours.

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Affiliation: Department of Surgical Pathology, Regina Elena Cancer Institute, 00144, Rome, Italy. marandino@ifo.it

ABSTRACT

Background: The thymus arises in the ventral portion of the third and fourth pharyngeal pouch. It descends into the anterior mediastinum at 6th week of gestation. Any errors occurring during this process can cause dissemination of aberrant nodules that are responsible for most atypical thymomas.

Case presentation: The authors report a unusual case of type-A thymoma located in D10 and D11 vertebral bodies.The histology showed a uniform growth of short, spindle shaped, mitotically inactive cells. A few small, normal lymphocytes were seen scattered or in small groups. The immunohistochemical investigation for neuroectodermal, neuroendocrine, vascular and muscular markers were negative. It also confirmed the presence of CD3+, CD5+ T lymphocytes and the absence of immature T-lymphocyte markers.

Conclusions: The case described shows a thymic hystogenesis for spindle cell tumours. To our knowledge no other cases of vertebral thymomas have been described in international literature.

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Immunohistology for CD20. Immunohistology showing positivity for CD20 20X magnification
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Figure 5: Immunohistology for CD20. Immunohistology showing positivity for CD20 20X magnification

Mentions: Furthermore, vimentin, epithelial membrane antigen (EMA), CD56, cytokeratin 8, BCL2 (week), were focally positive. The staining for CD20 showed an extensive multi-focal positive membranous staining of the spindle epithelial cells (fig. 5). The small lymphocytes were mature T lymphocytes CD3+, CD5+, negative for the immature T- lymphocyte markers CD1a, CD10, CD99. The staining for collagen IV showed strong intercellular deposition of the collagen among ribbons and nests of spindle cells (fig. 6). Varying from the tumour cells, scattered accessory cells were found to be positive for smooth muscle actin, S100, CD1a and CD68.


Ectopic primary type A thymoma located in two thoracic vertebras: a case report.

Marandino F, Zoccali C, Salducca N, Marino M, Visca P - BMC Cancer (2010)

Immunohistology for CD20. Immunohistology showing positivity for CD20 20X magnification
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2903530&req=5

Figure 5: Immunohistology for CD20. Immunohistology showing positivity for CD20 20X magnification
Mentions: Furthermore, vimentin, epithelial membrane antigen (EMA), CD56, cytokeratin 8, BCL2 (week), were focally positive. The staining for CD20 showed an extensive multi-focal positive membranous staining of the spindle epithelial cells (fig. 5). The small lymphocytes were mature T lymphocytes CD3+, CD5+, negative for the immature T- lymphocyte markers CD1a, CD10, CD99. The staining for collagen IV showed strong intercellular deposition of the collagen among ribbons and nests of spindle cells (fig. 6). Varying from the tumour cells, scattered accessory cells were found to be positive for smooth muscle actin, S100, CD1a and CD68.

Bottom Line: The immunohistochemical investigation for neuroectodermal, neuroendocrine, vascular and muscular markers were negative.It also confirmed the presence of CD3+, CD5+ T lymphocytes and the absence of immature T-lymphocyte markers.The case described shows a thymic hystogenesis for spindle cell tumours.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgical Pathology, Regina Elena Cancer Institute, 00144, Rome, Italy. marandino@ifo.it

ABSTRACT

Background: The thymus arises in the ventral portion of the third and fourth pharyngeal pouch. It descends into the anterior mediastinum at 6th week of gestation. Any errors occurring during this process can cause dissemination of aberrant nodules that are responsible for most atypical thymomas.

Case presentation: The authors report a unusual case of type-A thymoma located in D10 and D11 vertebral bodies.The histology showed a uniform growth of short, spindle shaped, mitotically inactive cells. A few small, normal lymphocytes were seen scattered or in small groups. The immunohistochemical investigation for neuroectodermal, neuroendocrine, vascular and muscular markers were negative. It also confirmed the presence of CD3+, CD5+ T lymphocytes and the absence of immature T-lymphocyte markers.

Conclusions: The case described shows a thymic hystogenesis for spindle cell tumours. To our knowledge no other cases of vertebral thymomas have been described in international literature.

Show MeSH
Related in: MedlinePlus