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Ectopic primary type A thymoma located in two thoracic vertebras: a case report.

Marandino F, Zoccali C, Salducca N, Marino M, Visca P - BMC Cancer (2010)

Bottom Line: The immunohistochemical investigation for neuroectodermal, neuroendocrine, vascular and muscular markers were negative.It also confirmed the presence of CD3+, CD5+ T lymphocytes and the absence of immature T-lymphocyte markers.The case described shows a thymic hystogenesis for spindle cell tumours.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgical Pathology, Regina Elena Cancer Institute, 00144, Rome, Italy. marandino@ifo.it

ABSTRACT

Background: The thymus arises in the ventral portion of the third and fourth pharyngeal pouch. It descends into the anterior mediastinum at 6th week of gestation. Any errors occurring during this process can cause dissemination of aberrant nodules that are responsible for most atypical thymomas.

Case presentation: The authors report a unusual case of type-A thymoma located in D10 and D11 vertebral bodies.The histology showed a uniform growth of short, spindle shaped, mitotically inactive cells. A few small, normal lymphocytes were seen scattered or in small groups. The immunohistochemical investigation for neuroectodermal, neuroendocrine, vascular and muscular markers were negative. It also confirmed the presence of CD3+, CD5+ T lymphocytes and the absence of immature T-lymphocyte markers.

Conclusions: The case described shows a thymic hystogenesis for spindle cell tumours. To our knowledge no other cases of vertebral thymomas have been described in international literature.

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Chest CT of lesion. Chest CT showing osteolytic lesion of D11 eroding anterior cortex and superior endplate and involving superior vertebral body.
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Figure 1: Chest CT of lesion. Chest CT showing osteolytic lesion of D11 eroding anterior cortex and superior endplate and involving superior vertebral body.

Mentions: Clinical examination results showed localized pain increasing with compression. A systemic examination was performed and tested negative. Laboratory studies were not helpful. X-rays revealed an osteolytic lesion eroding the anterior cortex, the superior endplate involving the upper vertebra (fig. 1). The CT-scan and MRI (fig. 2) confirmed the subtotal substitution of the vertebral body. A CT-scan performed about one year before confirmed similar results. The bone scan indicated a slight increase in local uptake and no sign of bone metastasis, the condition was confirmed by a total-body CT-SCAN. While X-rays and CT-scans of the chest were normal.


Ectopic primary type A thymoma located in two thoracic vertebras: a case report.

Marandino F, Zoccali C, Salducca N, Marino M, Visca P - BMC Cancer (2010)

Chest CT of lesion. Chest CT showing osteolytic lesion of D11 eroding anterior cortex and superior endplate and involving superior vertebral body.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2903530&req=5

Figure 1: Chest CT of lesion. Chest CT showing osteolytic lesion of D11 eroding anterior cortex and superior endplate and involving superior vertebral body.
Mentions: Clinical examination results showed localized pain increasing with compression. A systemic examination was performed and tested negative. Laboratory studies were not helpful. X-rays revealed an osteolytic lesion eroding the anterior cortex, the superior endplate involving the upper vertebra (fig. 1). The CT-scan and MRI (fig. 2) confirmed the subtotal substitution of the vertebral body. A CT-scan performed about one year before confirmed similar results. The bone scan indicated a slight increase in local uptake and no sign of bone metastasis, the condition was confirmed by a total-body CT-SCAN. While X-rays and CT-scans of the chest were normal.

Bottom Line: The immunohistochemical investigation for neuroectodermal, neuroendocrine, vascular and muscular markers were negative.It also confirmed the presence of CD3+, CD5+ T lymphocytes and the absence of immature T-lymphocyte markers.The case described shows a thymic hystogenesis for spindle cell tumours.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Surgical Pathology, Regina Elena Cancer Institute, 00144, Rome, Italy. marandino@ifo.it

ABSTRACT

Background: The thymus arises in the ventral portion of the third and fourth pharyngeal pouch. It descends into the anterior mediastinum at 6th week of gestation. Any errors occurring during this process can cause dissemination of aberrant nodules that are responsible for most atypical thymomas.

Case presentation: The authors report a unusual case of type-A thymoma located in D10 and D11 vertebral bodies.The histology showed a uniform growth of short, spindle shaped, mitotically inactive cells. A few small, normal lymphocytes were seen scattered or in small groups. The immunohistochemical investigation for neuroectodermal, neuroendocrine, vascular and muscular markers were negative. It also confirmed the presence of CD3+, CD5+ T lymphocytes and the absence of immature T-lymphocyte markers.

Conclusions: The case described shows a thymic hystogenesis for spindle cell tumours. To our knowledge no other cases of vertebral thymomas have been described in international literature.

Show MeSH
Related in: MedlinePlus