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Periostin is up-regulated in high grade and high stage prostate cancer.

Tischler V, Fritzsche FR, Wild PJ, Stephan C, Seifert HH, Riener MO, Hermanns T, Mortezavi A, Gerhardt J, Schraml P, Jung K, Moch H, Soltermann A, Kristiansen G - BMC Cancer (2010)

Bottom Line: Increased periostin expression in carcinoma cells was significantly associated with high Gleason score (p < 0.01) and advanced tumour stage (p < 0.05) in the test cohort.Whereas periostin expression was weak or absent in the stroma around normal prostate glands, strong periostin expression in tumour stroma was found in most primary and metastatic prostate cancers.High stromal periostin expression was associated with higher Gleason scores (p < 0.001).

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute for Surgical Pathology, University Hospital Zurich, Zurich, Switzerland.

ABSTRACT

Background: Expression of periostin is an indicator of epithelial-mesenchymal transition in cancer but a detailed analysis of periostin expression in prostate cancer has not been conducted so far.

Methods: Here, we evaluated periostin expression in prostate cancer cells and peritumoural stroma immunohistochemically in two independent prostate cancer cohorts, including a training cohort (n = 93) and a test cohort (n = 325). Metastatic prostate cancers (n = 20), hormone refractory prostate cancers (n = 19) and benign prostatic tissues (n = 38) were also analyzed.

Results: In total, strong epithelial periostin expression was detectable in 142 of 418 (34.0%) of prostate carcinomas and in 11 of 38 benign prostate glands (28.9%). Increased periostin expression in carcinoma cells was significantly associated with high Gleason score (p < 0.01) and advanced tumour stage (p < 0.05) in the test cohort. Whereas periostin expression was weak or absent in the stroma around normal prostate glands, strong periostin expression in tumour stroma was found in most primary and metastatic prostate cancers. High stromal periostin expression was associated with higher Gleason scores (p < 0.001). There was a relationship between stromal periostin expression and shortened PSA relapse free survival times in the training cohort (p < 0.05).

Conclusions: Our data indicate that periostin up-regulation is related to increased tumour aggressiveness in prostate cancer and might be a promising target for therapeutical interventions in primary and metastatic prostate cancer.

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PSA relapse free survival for periostin in training and test cohort. a) In the training cohort higher stromal periostin expression was a significant prognosticator for shortened PSA relapse free survival (p = 0.045). The periostin low group consisted of 70 patients of which 29 had a PSA relapse. In the periostin high group 14 of the 23 patients had a PSA relapse. b) In the test cohort the curve of those patients with higher stromal periostin expression remained slightly below that of the patients with lower stromal periostin expression (p = 0.373). In the test cohort the periostin low group consisted of 152 patients. Forty-six patients had a PSA relapse (periostin high group: 22 of the 59 patients with PSA relapse).
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Figure 2: PSA relapse free survival for periostin in training and test cohort. a) In the training cohort higher stromal periostin expression was a significant prognosticator for shortened PSA relapse free survival (p = 0.045). The periostin low group consisted of 70 patients of which 29 had a PSA relapse. In the periostin high group 14 of the 23 patients had a PSA relapse. b) In the test cohort the curve of those patients with higher stromal periostin expression remained slightly below that of the patients with lower stromal periostin expression (p = 0.373). In the test cohort the periostin low group consisted of 152 patients. Forty-six patients had a PSA relapse (periostin high group: 22 of the 59 patients with PSA relapse).

Mentions: The standard prognosticators (pT-status, Gleason score and residual tumour) correlated significantly with shortened PSA relapse free survival in both cohorts (Table 4, training cohort not shown). In the training cohort, high stromal periostin was significantly associated with shortened PSA relapse free survival times (p < 0.05; Figure 2a).


Periostin is up-regulated in high grade and high stage prostate cancer.

Tischler V, Fritzsche FR, Wild PJ, Stephan C, Seifert HH, Riener MO, Hermanns T, Mortezavi A, Gerhardt J, Schraml P, Jung K, Moch H, Soltermann A, Kristiansen G - BMC Cancer (2010)

PSA relapse free survival for periostin in training and test cohort. a) In the training cohort higher stromal periostin expression was a significant prognosticator for shortened PSA relapse free survival (p = 0.045). The periostin low group consisted of 70 patients of which 29 had a PSA relapse. In the periostin high group 14 of the 23 patients had a PSA relapse. b) In the test cohort the curve of those patients with higher stromal periostin expression remained slightly below that of the patients with lower stromal periostin expression (p = 0.373). In the test cohort the periostin low group consisted of 152 patients. Forty-six patients had a PSA relapse (periostin high group: 22 of the 59 patients with PSA relapse).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2903527&req=5

Figure 2: PSA relapse free survival for periostin in training and test cohort. a) In the training cohort higher stromal periostin expression was a significant prognosticator for shortened PSA relapse free survival (p = 0.045). The periostin low group consisted of 70 patients of which 29 had a PSA relapse. In the periostin high group 14 of the 23 patients had a PSA relapse. b) In the test cohort the curve of those patients with higher stromal periostin expression remained slightly below that of the patients with lower stromal periostin expression (p = 0.373). In the test cohort the periostin low group consisted of 152 patients. Forty-six patients had a PSA relapse (periostin high group: 22 of the 59 patients with PSA relapse).
Mentions: The standard prognosticators (pT-status, Gleason score and residual tumour) correlated significantly with shortened PSA relapse free survival in both cohorts (Table 4, training cohort not shown). In the training cohort, high stromal periostin was significantly associated with shortened PSA relapse free survival times (p < 0.05; Figure 2a).

Bottom Line: Increased periostin expression in carcinoma cells was significantly associated with high Gleason score (p < 0.01) and advanced tumour stage (p < 0.05) in the test cohort.Whereas periostin expression was weak or absent in the stroma around normal prostate glands, strong periostin expression in tumour stroma was found in most primary and metastatic prostate cancers.High stromal periostin expression was associated with higher Gleason scores (p < 0.001).

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute for Surgical Pathology, University Hospital Zurich, Zurich, Switzerland.

ABSTRACT

Background: Expression of periostin is an indicator of epithelial-mesenchymal transition in cancer but a detailed analysis of periostin expression in prostate cancer has not been conducted so far.

Methods: Here, we evaluated periostin expression in prostate cancer cells and peritumoural stroma immunohistochemically in two independent prostate cancer cohorts, including a training cohort (n = 93) and a test cohort (n = 325). Metastatic prostate cancers (n = 20), hormone refractory prostate cancers (n = 19) and benign prostatic tissues (n = 38) were also analyzed.

Results: In total, strong epithelial periostin expression was detectable in 142 of 418 (34.0%) of prostate carcinomas and in 11 of 38 benign prostate glands (28.9%). Increased periostin expression in carcinoma cells was significantly associated with high Gleason score (p < 0.01) and advanced tumour stage (p < 0.05) in the test cohort. Whereas periostin expression was weak or absent in the stroma around normal prostate glands, strong periostin expression in tumour stroma was found in most primary and metastatic prostate cancers. High stromal periostin expression was associated with higher Gleason scores (p < 0.001). There was a relationship between stromal periostin expression and shortened PSA relapse free survival times in the training cohort (p < 0.05).

Conclusions: Our data indicate that periostin up-regulation is related to increased tumour aggressiveness in prostate cancer and might be a promising target for therapeutical interventions in primary and metastatic prostate cancer.

Show MeSH
Related in: MedlinePlus