Limits...
The impact of Highly Active Antiretroviral Therapy (HAART) on the clinical features of HIV - related oral lesions in Nigeria.

Taiwo OO, Hassan Z - AIDS Res Ther (2010)

Bottom Line: Eighty (56.3%) were females.There was no clinical change noticed in linear gingival erythema.These lesions alongside immunologic parameters can be used as indicators of success or failure of antiretroviral therapy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Regional Centre for Oral Health Research and Training Initiatives (RCORTI) for Africa, Jos, Nigeria. taiwo25@yahoo.co.uk.

ABSTRACT

Background: This study aimed to determine the therapeutic effects of highly active anti-retroviral therapy (HAART) on the clinical presentations of HIV related oral lesions (HIV-ROLs) in an adult Nigerian population.

Methods: A 5 month prospective study on HAART naïve HIV positive adults recruited into the HAART program of an AIDS referral centre. HIV-ROLs were diagnosed clinically by the EEC Clearinghouse on oral problems related to HIV infection. Baseline clinical features of HIV-ROLs was documented by clinical photographs using SONY(R) 5.2 M Cybershot digital camera. Post HAART monthly review was conducted using clinical photographs.

Results: A total of 142 patients were seen. Age range was 19 - 75 years. Mean age was 35.6 +/- 10.5 (SD). Eighty (56.3%) were females. Prevalence of HIV-ROLs was 43.7%. Oral candidiasis (22.4%) was the most prevalent HIV-ROL. 114 (83.2%) patients had clinical AIDS at presentation (CDC 1993). 89.4% were placed on Tenofovir/Emtricitabine +;Nevirapine, 9.9% on Tenofovir/Emtricitabine + Efavirenz. There was strong decline in the clinical features of oral candidiasis from a month of commencing HAART. Oral hairy leukoplakia was slow in responding to HAART. Parotid gland enlargement, melanotic hyperpigmentation and Kaposi's sarcoma were more persistent and had slower response to HAART. There was no clinical change noticed in linear gingival erythema.

Conclusion: HAART has different clinical effects on HIV related oral lesions depending on the size, duration of treatment and etiology of the lesions. HIV-ROLs of fungal origin have the fastest response to HAART. These lesions alongside immunologic parameters can be used as indicators of success or failure of antiretroviral therapy.

No MeSH data available.


Related in: MedlinePlus

Kaposi's Sarcoma Patient on: Tenofovir/Emtricitabine + Nevirapine
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2903493&req=5

Figure 6: Kaposi's Sarcoma Patient on: Tenofovir/Emtricitabine + Nevirapine

Mentions: Parotid gland enlargement (figure 4), melanotic hyperpigmentation (figure 5) and Kaposi's sarcoma (figure 6) were more persistent and had slower response to HAART. For all the lesions monitored, none was able to achieve complete resolution during the period of observation. For the first few months, there was negligible change in the clinical features of melanotic hyperpigmentation. Gradual decrease in size was also noticed for parotid gland enlargement and Kaposi's sarcoma. There was no change observed in the only case of linear gingival erythema noticed throughout the duration of the study. Table 4 shows the relationship between the prevalence of the oral manifestations of HIV/AIDS and the immunologic parameters from the commencement of HAART to 24 weeks.


The impact of Highly Active Antiretroviral Therapy (HAART) on the clinical features of HIV - related oral lesions in Nigeria.

Taiwo OO, Hassan Z - AIDS Res Ther (2010)

Kaposi's Sarcoma Patient on: Tenofovir/Emtricitabine + Nevirapine
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2903493&req=5

Figure 6: Kaposi's Sarcoma Patient on: Tenofovir/Emtricitabine + Nevirapine
Mentions: Parotid gland enlargement (figure 4), melanotic hyperpigmentation (figure 5) and Kaposi's sarcoma (figure 6) were more persistent and had slower response to HAART. For all the lesions monitored, none was able to achieve complete resolution during the period of observation. For the first few months, there was negligible change in the clinical features of melanotic hyperpigmentation. Gradual decrease in size was also noticed for parotid gland enlargement and Kaposi's sarcoma. There was no change observed in the only case of linear gingival erythema noticed throughout the duration of the study. Table 4 shows the relationship between the prevalence of the oral manifestations of HIV/AIDS and the immunologic parameters from the commencement of HAART to 24 weeks.

Bottom Line: Eighty (56.3%) were females.There was no clinical change noticed in linear gingival erythema.These lesions alongside immunologic parameters can be used as indicators of success or failure of antiretroviral therapy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Regional Centre for Oral Health Research and Training Initiatives (RCORTI) for Africa, Jos, Nigeria. taiwo25@yahoo.co.uk.

ABSTRACT

Background: This study aimed to determine the therapeutic effects of highly active anti-retroviral therapy (HAART) on the clinical presentations of HIV related oral lesions (HIV-ROLs) in an adult Nigerian population.

Methods: A 5 month prospective study on HAART naïve HIV positive adults recruited into the HAART program of an AIDS referral centre. HIV-ROLs were diagnosed clinically by the EEC Clearinghouse on oral problems related to HIV infection. Baseline clinical features of HIV-ROLs was documented by clinical photographs using SONY(R) 5.2 M Cybershot digital camera. Post HAART monthly review was conducted using clinical photographs.

Results: A total of 142 patients were seen. Age range was 19 - 75 years. Mean age was 35.6 +/- 10.5 (SD). Eighty (56.3%) were females. Prevalence of HIV-ROLs was 43.7%. Oral candidiasis (22.4%) was the most prevalent HIV-ROL. 114 (83.2%) patients had clinical AIDS at presentation (CDC 1993). 89.4% were placed on Tenofovir/Emtricitabine +;Nevirapine, 9.9% on Tenofovir/Emtricitabine + Efavirenz. There was strong decline in the clinical features of oral candidiasis from a month of commencing HAART. Oral hairy leukoplakia was slow in responding to HAART. Parotid gland enlargement, melanotic hyperpigmentation and Kaposi's sarcoma were more persistent and had slower response to HAART. There was no clinical change noticed in linear gingival erythema.

Conclusion: HAART has different clinical effects on HIV related oral lesions depending on the size, duration of treatment and etiology of the lesions. HIV-ROLs of fungal origin have the fastest response to HAART. These lesions alongside immunologic parameters can be used as indicators of success or failure of antiretroviral therapy.

No MeSH data available.


Related in: MedlinePlus