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The integration of prosodic speech in high functioning autism: a preliminary FMRI study.

Hesling I, Dilharreguy B, Peppé S, Amirault M, Bouvard M, Allard M - PLoS ONE (2010)

Bottom Line: The aim of the present study was to characterize specific prosodic components such as linguistic prosody (intonation, rhythm and emphasis) and emotional prosody and to correlate them with the neural network underlying them.Results revealed the existence of a link between perceptive and productive prosodic deficits for some prosodic components (rhythm, emphasis and affect) in HFA and also revealed that the neural network involved in prosodic speech perception exhibits abnormal activation in the left SMG as compared to controls (activation positively correlated with intonation and emphasis) and an absence of deactivation patterns in regions involved in the default mode.These prosodic impairments could not only result from activation patterns abnormalities but also from an inability to adequately use the strategy of the default network inhibition, both mechanisms that have to be considered for decreasing task performance in High Functioning Autism.

View Article: PubMed Central - PubMed

Affiliation: UMR-CNRS 5231, Laboratoire d'Imagerie Moléculaire et Fonctionnelle, Université Victor Segalen, Bordeaux, France. isabelle.hesling@wanadoo.fr

ABSTRACT

Background: Autism is a neurodevelopmental disorder characterized by a specific triad of symptoms such as abnormalities in social interaction, abnormalities in communication and restricted activities and interests. While verbal autistic subjects may present a correct mastery of the formal aspects of speech, they have difficulties in prosody (music of speech), leading to communication disorders. Few behavioural studies have revealed a prosodic impairment in children with autism, and among the few fMRI studies aiming at assessing the neural network involved in language, none has specifically studied prosodic speech. The aim of the present study was to characterize specific prosodic components such as linguistic prosody (intonation, rhythm and emphasis) and emotional prosody and to correlate them with the neural network underlying them.

Methodology/principal findings: We used a behavioural test (Profiling Elements of the Prosodic System, PEPS) and fMRI to characterize prosodic deficits and investigate the neural network underlying prosodic processing. Results revealed the existence of a link between perceptive and productive prosodic deficits for some prosodic components (rhythm, emphasis and affect) in HFA and also revealed that the neural network involved in prosodic speech perception exhibits abnormal activation in the left SMG as compared to controls (activation positively correlated with intonation and emphasis) and an absence of deactivation patterns in regions involved in the default mode.

Conclusions/significance: These prosodic impairments could not only result from activation patterns abnormalities but also from an inability to adequately use the strategy of the default network inhibition, both mechanisms that have to be considered for decreasing task performance in High Functioning Autism.

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Related in: MedlinePlus

French PEPS input results.
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pone-0011571-g001: French PEPS input results.

Mentions: Controls performed all the perceptive and productive tasks at nearly ceiling, though the test cannot be considered as saturated since the score of 100% was only obtained for 2 subtests (expressive Turn-end and expressive chunking). The HFA group's results were significantly lower than those of controls for all the input and output tasks (p<0.001), (Figure 1).


The integration of prosodic speech in high functioning autism: a preliminary FMRI study.

Hesling I, Dilharreguy B, Peppé S, Amirault M, Bouvard M, Allard M - PLoS ONE (2010)

French PEPS input results.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2903486&req=5

pone-0011571-g001: French PEPS input results.
Mentions: Controls performed all the perceptive and productive tasks at nearly ceiling, though the test cannot be considered as saturated since the score of 100% was only obtained for 2 subtests (expressive Turn-end and expressive chunking). The HFA group's results were significantly lower than those of controls for all the input and output tasks (p<0.001), (Figure 1).

Bottom Line: The aim of the present study was to characterize specific prosodic components such as linguistic prosody (intonation, rhythm and emphasis) and emotional prosody and to correlate them with the neural network underlying them.Results revealed the existence of a link between perceptive and productive prosodic deficits for some prosodic components (rhythm, emphasis and affect) in HFA and also revealed that the neural network involved in prosodic speech perception exhibits abnormal activation in the left SMG as compared to controls (activation positively correlated with intonation and emphasis) and an absence of deactivation patterns in regions involved in the default mode.These prosodic impairments could not only result from activation patterns abnormalities but also from an inability to adequately use the strategy of the default network inhibition, both mechanisms that have to be considered for decreasing task performance in High Functioning Autism.

View Article: PubMed Central - PubMed

Affiliation: UMR-CNRS 5231, Laboratoire d'Imagerie Moléculaire et Fonctionnelle, Université Victor Segalen, Bordeaux, France. isabelle.hesling@wanadoo.fr

ABSTRACT

Background: Autism is a neurodevelopmental disorder characterized by a specific triad of symptoms such as abnormalities in social interaction, abnormalities in communication and restricted activities and interests. While verbal autistic subjects may present a correct mastery of the formal aspects of speech, they have difficulties in prosody (music of speech), leading to communication disorders. Few behavioural studies have revealed a prosodic impairment in children with autism, and among the few fMRI studies aiming at assessing the neural network involved in language, none has specifically studied prosodic speech. The aim of the present study was to characterize specific prosodic components such as linguistic prosody (intonation, rhythm and emphasis) and emotional prosody and to correlate them with the neural network underlying them.

Methodology/principal findings: We used a behavioural test (Profiling Elements of the Prosodic System, PEPS) and fMRI to characterize prosodic deficits and investigate the neural network underlying prosodic processing. Results revealed the existence of a link between perceptive and productive prosodic deficits for some prosodic components (rhythm, emphasis and affect) in HFA and also revealed that the neural network involved in prosodic speech perception exhibits abnormal activation in the left SMG as compared to controls (activation positively correlated with intonation and emphasis) and an absence of deactivation patterns in regions involved in the default mode.

Conclusions/significance: These prosodic impairments could not only result from activation patterns abnormalities but also from an inability to adequately use the strategy of the default network inhibition, both mechanisms that have to be considered for decreasing task performance in High Functioning Autism.

Show MeSH
Related in: MedlinePlus