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FADS2 polymorphisms modify the effect of breastfeeding on child IQ.

Steer CD, Davey Smith G, Emmett PM, Hibbeln JR, Golding J - PLoS ONE (2010)

Bottom Line: In our study of 5934 children aged 8 years, no genetic main effect with IQ was found for rs174575.This study also investigated rs1535, another FADS2 polymorphism in linkage disequilibrium with rs174575, together with performance and verbal IQ, finding similar results although effect sizes were generally reduced.This study did not replicate the findings of Caspi et al.

View Article: PubMed Central - PubMed

Affiliation: Centre for Child and Adolescent Health, Department of Community Based Medicine, University of Bristol, Bristol, UK. Colin.Steer@bristol.ac.uk

ABSTRACT

Background: Breastfeeding is important for child cognitive development. A study by Caspi et al has suggested that rs174575 within the FADS2 gene moderates this effect so that children homozygous in the minor allele (GG genotype) have similar IQs irrespective of feeding method.

Methods and principal findings: In our study of 5934 children aged 8 years, no genetic main effect with IQ was found for rs174575. However, an interaction with this polymorphism was observed such that breastfed GG children performed better than their formula fed counterparts by an additional 5.8 points [1.4, 10.1] (interaction p = 0.0091). Interaction results were attenuated by about 10% after adjustment for 7 factors. This study also investigated rs1535, another FADS2 polymorphism in linkage disequilibrium with rs174575, together with performance and verbal IQ, finding similar results although effect sizes were generally reduced.

Conclusions and significance: This study did not replicate the findings of Caspi et al. In contrast to their study, GG children exhibited the greatest difference between feeding methods such that breastfed children performed similarly irrespective of child genotype whereas formula fed GG children performed worse than other children on formula milk. Further studies are required to replicate these findings.

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Related in: MedlinePlus

Unadjusted means for Full-scale IQ at 8 years for breastfeeding (yes/no) and child FADS2 genotypes with 95% CIs (N = 5045 (A) and 5099 (B)).Mean IQ scores are calculated for each genotype of the polymorphisms rs174575 (A) and rs1535 (B) with subgroups who were ever breastfed in the first month after birth (black bars) and others not breast fed (grey bars). In addition to the breastfeeding effect (p<0.0001), GG children had particularly low scores when not breastfed (p interaction  = 0.0091 (A) and 0.031 (B)).
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pone-0011570-g001: Unadjusted means for Full-scale IQ at 8 years for breastfeeding (yes/no) and child FADS2 genotypes with 95% CIs (N = 5045 (A) and 5099 (B)).Mean IQ scores are calculated for each genotype of the polymorphisms rs174575 (A) and rs1535 (B) with subgroups who were ever breastfed in the first month after birth (black bars) and others not breast fed (grey bars). In addition to the breastfeeding effect (p<0.0001), GG children had particularly low scores when not breastfed (p interaction  = 0.0091 (A) and 0.031 (B)).

Mentions: IQ was also associated with an interaction between breastfeeding and child genotype. The strongest effects were noted for rs174575 and full-scale IQ although similar effects were observed for rs1535 and for other IQ measures. GG children showed the largest difference between any breastfeeding and exclusive use of formula feeds (see Figure 1). In particular these formula-fed children achieved the lowest scores on average while their breastfed counterparts achieved similar results to other breastfed children carrying the C or A allele (interaction p = 0.0091 for rs174575 and 0.031 for rs1535). This interaction can be interpreted, taking rs174575 as an example, as an association with IQ of −4.3 [95% CI −8.2, −0.4; p = 0.032] points for the GG genotype compared to CC+CG genotypes in formula fed children while breastfed children showed no association (B = 1.5 [95% CI −0.4, 3.4; p = 0.12]). Combining both feeding groups, there was no association with child genotype.


FADS2 polymorphisms modify the effect of breastfeeding on child IQ.

Steer CD, Davey Smith G, Emmett PM, Hibbeln JR, Golding J - PLoS ONE (2010)

Unadjusted means for Full-scale IQ at 8 years for breastfeeding (yes/no) and child FADS2 genotypes with 95% CIs (N = 5045 (A) and 5099 (B)).Mean IQ scores are calculated for each genotype of the polymorphisms rs174575 (A) and rs1535 (B) with subgroups who were ever breastfed in the first month after birth (black bars) and others not breast fed (grey bars). In addition to the breastfeeding effect (p<0.0001), GG children had particularly low scores when not breastfed (p interaction  = 0.0091 (A) and 0.031 (B)).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2903485&req=5

pone-0011570-g001: Unadjusted means for Full-scale IQ at 8 years for breastfeeding (yes/no) and child FADS2 genotypes with 95% CIs (N = 5045 (A) and 5099 (B)).Mean IQ scores are calculated for each genotype of the polymorphisms rs174575 (A) and rs1535 (B) with subgroups who were ever breastfed in the first month after birth (black bars) and others not breast fed (grey bars). In addition to the breastfeeding effect (p<0.0001), GG children had particularly low scores when not breastfed (p interaction  = 0.0091 (A) and 0.031 (B)).
Mentions: IQ was also associated with an interaction between breastfeeding and child genotype. The strongest effects were noted for rs174575 and full-scale IQ although similar effects were observed for rs1535 and for other IQ measures. GG children showed the largest difference between any breastfeeding and exclusive use of formula feeds (see Figure 1). In particular these formula-fed children achieved the lowest scores on average while their breastfed counterparts achieved similar results to other breastfed children carrying the C or A allele (interaction p = 0.0091 for rs174575 and 0.031 for rs1535). This interaction can be interpreted, taking rs174575 as an example, as an association with IQ of −4.3 [95% CI −8.2, −0.4; p = 0.032] points for the GG genotype compared to CC+CG genotypes in formula fed children while breastfed children showed no association (B = 1.5 [95% CI −0.4, 3.4; p = 0.12]). Combining both feeding groups, there was no association with child genotype.

Bottom Line: In our study of 5934 children aged 8 years, no genetic main effect with IQ was found for rs174575.This study also investigated rs1535, another FADS2 polymorphism in linkage disequilibrium with rs174575, together with performance and verbal IQ, finding similar results although effect sizes were generally reduced.This study did not replicate the findings of Caspi et al.

View Article: PubMed Central - PubMed

Affiliation: Centre for Child and Adolescent Health, Department of Community Based Medicine, University of Bristol, Bristol, UK. Colin.Steer@bristol.ac.uk

ABSTRACT

Background: Breastfeeding is important for child cognitive development. A study by Caspi et al has suggested that rs174575 within the FADS2 gene moderates this effect so that children homozygous in the minor allele (GG genotype) have similar IQs irrespective of feeding method.

Methods and principal findings: In our study of 5934 children aged 8 years, no genetic main effect with IQ was found for rs174575. However, an interaction with this polymorphism was observed such that breastfed GG children performed better than their formula fed counterparts by an additional 5.8 points [1.4, 10.1] (interaction p = 0.0091). Interaction results were attenuated by about 10% after adjustment for 7 factors. This study also investigated rs1535, another FADS2 polymorphism in linkage disequilibrium with rs174575, together with performance and verbal IQ, finding similar results although effect sizes were generally reduced.

Conclusions and significance: This study did not replicate the findings of Caspi et al. In contrast to their study, GG children exhibited the greatest difference between feeding methods such that breastfed children performed similarly irrespective of child genotype whereas formula fed GG children performed worse than other children on formula milk. Further studies are required to replicate these findings.

Show MeSH
Related in: MedlinePlus