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The impact of nanomaterials in immune system.

Jang J, Lim DH, Choi IH - Immune Netw (2010)

Bottom Line: As a nanotechnology has been actively applied to the overall areas of scientific fields, it is necessary to understand the characteristic features, physical behaviors and the potential effects of exposure to nanomaterials and their toxicity.In this article we review the immunological influences induced by several nanomaterials and emphasize establishment of the animal models to estimate the impact of these nanomaterials on development of immunological diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology, College of Medicine and Nanomedical National Core Research Center, Yonsei University, Seoul, Korea.

ABSTRACT
As a nanotechnology has been actively applied to the overall areas of scientific fields, it is necessary to understand the characteristic features, physical behaviors and the potential effects of exposure to nanomaterials and their toxicity. In this article we review the immunological influences induced by several nanomaterials and emphasize establishment of the animal models to estimate the impact of these nanomaterials on development of immunological diseases.

No MeSH data available.


Related in: MedlinePlus

Potential contribution of nanomaterials on asthma pathophysiology.
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Related In: Results  -  Collection

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Figure 1: Potential contribution of nanomaterials on asthma pathophysiology.

Mentions: In regard to the effects of nanoparticles on the asthma, a murine model of albumin-induced asthma has shown that the inflammatory responses and the production of immunoglobluins were increased by nanoparticles in the respiratory tract (Fig. 1). These inflammatory phenomena are explained by the expression of IL-5 and eotaxin which was induced in the early stage of inflammation. Subsequently, with the induced expression of such cytokines as IL-13, RANTES and MCP-1, the degree of inflammation was further increased. Moreover, based on the reports that TiO2 which has frequently been used for cosmetic products aggravates the atopic dermatitis, it has been proposed that nanoparticles might aggravate the immune diseases.


The impact of nanomaterials in immune system.

Jang J, Lim DH, Choi IH - Immune Netw (2010)

Potential contribution of nanomaterials on asthma pathophysiology.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2902674&req=5

Figure 1: Potential contribution of nanomaterials on asthma pathophysiology.
Mentions: In regard to the effects of nanoparticles on the asthma, a murine model of albumin-induced asthma has shown that the inflammatory responses and the production of immunoglobluins were increased by nanoparticles in the respiratory tract (Fig. 1). These inflammatory phenomena are explained by the expression of IL-5 and eotaxin which was induced in the early stage of inflammation. Subsequently, with the induced expression of such cytokines as IL-13, RANTES and MCP-1, the degree of inflammation was further increased. Moreover, based on the reports that TiO2 which has frequently been used for cosmetic products aggravates the atopic dermatitis, it has been proposed that nanoparticles might aggravate the immune diseases.

Bottom Line: As a nanotechnology has been actively applied to the overall areas of scientific fields, it is necessary to understand the characteristic features, physical behaviors and the potential effects of exposure to nanomaterials and their toxicity.In this article we review the immunological influences induced by several nanomaterials and emphasize establishment of the animal models to estimate the impact of these nanomaterials on development of immunological diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Microbiology, College of Medicine and Nanomedical National Core Research Center, Yonsei University, Seoul, Korea.

ABSTRACT
As a nanotechnology has been actively applied to the overall areas of scientific fields, it is necessary to understand the characteristic features, physical behaviors and the potential effects of exposure to nanomaterials and their toxicity. In this article we review the immunological influences induced by several nanomaterials and emphasize establishment of the animal models to estimate the impact of these nanomaterials on development of immunological diseases.

No MeSH data available.


Related in: MedlinePlus