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Outcome measures in chronic obstructive pulmonary disease (COPD): strengths and limitations.

Glaab T, Vogelmeier C, Buhl R - Respir. Res. (2010)

Bottom Line: Current methods for assessing clinical outcomes in COPD mainly rely on physiological tests combined with the use of questionnaires.The present review considers commonly used outcome measures such as lung function, health status, exercise capacity and physical activity, dyspnoea, exacerbations, the multi-dimensional BODE score, and mortality.Based on current published data, we provide a concise overview of the principles, strengths and weaknesses, and discuss open questions related to each methodology.

View Article: PubMed Central - HTML - PubMed

Affiliation: Pulmonary Department, University Hospital, Johannes Gutenberg-University, Mainz, Germany.

ABSTRACT
Current methods for assessing clinical outcomes in COPD mainly rely on physiological tests combined with the use of questionnaires. The present review considers commonly used outcome measures such as lung function, health status, exercise capacity and physical activity, dyspnoea, exacerbations, the multi-dimensional BODE score, and mortality. Based on current published data, we provide a concise overview of the principles, strengths and weaknesses, and discuss open questions related to each methodology. Reviewed is the current set of markers for measuring clinically relevant outcomes with particular emphasis on their limitations and opportunities that should be recognized when assessing and interpreting their use in clinical trials of COPD.

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Outcome measures relevant for the evaluation of COPD management.
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Figure 1: Outcome measures relevant for the evaluation of COPD management.

Mentions: Chronic obstructive pulmonary disease (COPD) is a heterogeneous, multi-component disease associated with significant clinical burden. Though the presence of airflow limitation is well recognised as the pathophysiological basis, COPD as a complex disorder requires a multifaceted approach with regard to clinical assessment and response to therapy. This has prompted an intense search for clinical trial endpoints that may adequately reflect the success or failure of treatment. Current methods for assessing COPD progression mainly rely on lung function tests with a particular focus on forced expiratory volume in 1 second (FEV1). However, clinical and patient-reported outcome measures such as dyspnoea, exercise capacity, physical activity, exacerbations, health status and mortality have been recognized and applied as an essential part of the clinical assessment of COPD beyond FEV1 measurements [1,2] (figure 1).


Outcome measures in chronic obstructive pulmonary disease (COPD): strengths and limitations.

Glaab T, Vogelmeier C, Buhl R - Respir. Res. (2010)

Outcome measures relevant for the evaluation of COPD management.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2902430&req=5

Figure 1: Outcome measures relevant for the evaluation of COPD management.
Mentions: Chronic obstructive pulmonary disease (COPD) is a heterogeneous, multi-component disease associated with significant clinical burden. Though the presence of airflow limitation is well recognised as the pathophysiological basis, COPD as a complex disorder requires a multifaceted approach with regard to clinical assessment and response to therapy. This has prompted an intense search for clinical trial endpoints that may adequately reflect the success or failure of treatment. Current methods for assessing COPD progression mainly rely on lung function tests with a particular focus on forced expiratory volume in 1 second (FEV1). However, clinical and patient-reported outcome measures such as dyspnoea, exercise capacity, physical activity, exacerbations, health status and mortality have been recognized and applied as an essential part of the clinical assessment of COPD beyond FEV1 measurements [1,2] (figure 1).

Bottom Line: Current methods for assessing clinical outcomes in COPD mainly rely on physiological tests combined with the use of questionnaires.The present review considers commonly used outcome measures such as lung function, health status, exercise capacity and physical activity, dyspnoea, exacerbations, the multi-dimensional BODE score, and mortality.Based on current published data, we provide a concise overview of the principles, strengths and weaknesses, and discuss open questions related to each methodology.

View Article: PubMed Central - HTML - PubMed

Affiliation: Pulmonary Department, University Hospital, Johannes Gutenberg-University, Mainz, Germany.

ABSTRACT
Current methods for assessing clinical outcomes in COPD mainly rely on physiological tests combined with the use of questionnaires. The present review considers commonly used outcome measures such as lung function, health status, exercise capacity and physical activity, dyspnoea, exacerbations, the multi-dimensional BODE score, and mortality. Based on current published data, we provide a concise overview of the principles, strengths and weaknesses, and discuss open questions related to each methodology. Reviewed is the current set of markers for measuring clinically relevant outcomes with particular emphasis on their limitations and opportunities that should be recognized when assessing and interpreting their use in clinical trials of COPD.

Show MeSH
Related in: MedlinePlus