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BELFAST nonagenarians: nature or nurture? Immunological, cardiovascular and genetic factors.

Rea IM - Immun Ageing (2010)

Bottom Line: Nonagenarians are the fastest growing sector of populations across Western European and the developed world.They are some of the oldest members of our societies and survivors of their generation and may help us understand how to age not only longer, but better.The Belfast Longevity Group enlisted the help of 500 community-living, mobile, mentally competent, 'elite' nonagenarians, as part of an ongoing study of ageing.We assessed some immunological, cardiovascular, nutritional and genetic factors and some aspects of their interaction in this group of 'oldest old'.Here we present some of the evidence related to genetic and nutritional factors which seem to be important for good quality ageing in nonagenarians from the Belfast Elderly Longitudinal Free-living Ageing STudy (BELFAST).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Geriatric Medicine, School of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland. i.rea@qub.ac.uk.

ABSTRACT
Nonagenarians are the fastest growing sector of populations across Western European and the developed world. They are some of the oldest members of our societies and survivors of their generation and may help us understand how to age not only longer, but better.The Belfast Longevity Group enlisted the help of 500 community-living, mobile, mentally competent, 'elite' nonagenarians, as part of an ongoing study of ageing. We assessed some immunological, cardiovascular, nutritional and genetic factors and some aspects of their interaction in this group of 'oldest old'.Here we present some of the evidence related to genetic and nutritional factors which seem to be important for good quality ageing in nonagenarians from the Belfast Elderly Longitudinal Free-living Ageing STudy (BELFAST).

No MeSH data available.


Tertiles of Systolic and Diastolic Blood Pressure in relation to Serum Sodium in BELFAST study. Systolic Blood Pressure. Tertile 1 < 120 mmHg. Tertile 2 120-140 mmHg. Tertile 3 > 140 mmHg.
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Figure 4: Tertiles of Systolic and Diastolic Blood Pressure in relation to Serum Sodium in BELFAST study. Systolic Blood Pressure. Tertile 1 < 120 mmHg. Tertile 2 120-140 mmHg. Tertile 3 > 140 mmHg.

Mentions: The 24 hour dietary intakes were analysed by CompEat [CompEat nutritional analysis program, Lifeline Nutritional Services, London]. This showed a relatively low sodium intake at approximately 2 grams daily (1836 mg for females and 2087 mg for males), compared to population averages of 4-7 grams daily, and this finding may contribute to the relatively normal blood pressure found in the BELFAST nonagenarian group [2]. Increasing tertiles of serum sodium, although only weakly associated to sodium intake by dietary recall [r2 = 0.27; p = 0.046], were significantly correlated with increasing tertiles of blood pressure in BELFAST nonagenarians (Figure 4).


BELFAST nonagenarians: nature or nurture? Immunological, cardiovascular and genetic factors.

Rea IM - Immun Ageing (2010)

Tertiles of Systolic and Diastolic Blood Pressure in relation to Serum Sodium in BELFAST study. Systolic Blood Pressure. Tertile 1 < 120 mmHg. Tertile 2 120-140 mmHg. Tertile 3 > 140 mmHg.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2902418&req=5

Figure 4: Tertiles of Systolic and Diastolic Blood Pressure in relation to Serum Sodium in BELFAST study. Systolic Blood Pressure. Tertile 1 < 120 mmHg. Tertile 2 120-140 mmHg. Tertile 3 > 140 mmHg.
Mentions: The 24 hour dietary intakes were analysed by CompEat [CompEat nutritional analysis program, Lifeline Nutritional Services, London]. This showed a relatively low sodium intake at approximately 2 grams daily (1836 mg for females and 2087 mg for males), compared to population averages of 4-7 grams daily, and this finding may contribute to the relatively normal blood pressure found in the BELFAST nonagenarian group [2]. Increasing tertiles of serum sodium, although only weakly associated to sodium intake by dietary recall [r2 = 0.27; p = 0.046], were significantly correlated with increasing tertiles of blood pressure in BELFAST nonagenarians (Figure 4).

Bottom Line: Nonagenarians are the fastest growing sector of populations across Western European and the developed world.They are some of the oldest members of our societies and survivors of their generation and may help us understand how to age not only longer, but better.The Belfast Longevity Group enlisted the help of 500 community-living, mobile, mentally competent, 'elite' nonagenarians, as part of an ongoing study of ageing.We assessed some immunological, cardiovascular, nutritional and genetic factors and some aspects of their interaction in this group of 'oldest old'.Here we present some of the evidence related to genetic and nutritional factors which seem to be important for good quality ageing in nonagenarians from the Belfast Elderly Longitudinal Free-living Ageing STudy (BELFAST).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Geriatric Medicine, School of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland. i.rea@qub.ac.uk.

ABSTRACT
Nonagenarians are the fastest growing sector of populations across Western European and the developed world. They are some of the oldest members of our societies and survivors of their generation and may help us understand how to age not only longer, but better.The Belfast Longevity Group enlisted the help of 500 community-living, mobile, mentally competent, 'elite' nonagenarians, as part of an ongoing study of ageing. We assessed some immunological, cardiovascular, nutritional and genetic factors and some aspects of their interaction in this group of 'oldest old'.Here we present some of the evidence related to genetic and nutritional factors which seem to be important for good quality ageing in nonagenarians from the Belfast Elderly Longitudinal Free-living Ageing STudy (BELFAST).

No MeSH data available.