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Objective cough frequency in Idiopathic Pulmonary Fibrosis.

Key AL, Holt K, Hamilton A, Smith JA, Earis JE - Cough (2010)

Bottom Line: Nineteen IPF patients, mean age 70.8 years +/- 8.6, five female (26.3%) were studied.The 24hr cough rates were high (median 9.4, range 1.5-39.4), with day time rates much higher than night time (median 14.6, range 1.9-56.6 compared to 1.9, range 0-19.2, p = 0.003).Strong correlations were found between objective cough frequency and both the VAS (day r = 0.80, p < 0.001, night r = 0.71, p = 0.001) and LCQ (r = -0.80, p < 0.001), but not with measures of pulmonary function.

View Article: PubMed Central - HTML - PubMed

Affiliation: Respiratory Department, Aintree University Hospitals NHS Foundation Trust, University Hospital Aintree, Longmoor Lane Liverpool, L9 7AL, UK. J.E.Earis@liverpool.ac.uk.

ABSTRACT

Background: Cough is a common presenting symptom in patients with Idiopathic Pulmonary Fibrosis (IPF). This study measured cough rates in IPF patients and investigated the association between cough and measures of health related quality of life and subjective cough assessments. In addition, IPF cough rates were related to measures of physiological disease severity and compared to cough rates in health and other respiratory conditions.

Methods: Nineteen IPF patients, mean age 70.8 years +/- 8.6, five female (26.3%) were studied. Subjects performed full pulmonary function testing, 24 hour ambulatory cough recordings, completed a cough related quality of life questionnaire (Leicester Cough Questionnaire) and subjectively scored cough severity with a visual analogue scale. Ambulatory cough recordings were manually counted and reported as number of coughs per hour.

Results: The 24hr cough rates were high (median 9.4, range 1.5-39.4), with day time rates much higher than night time (median 14.6, range 1.9-56.6 compared to 1.9, range 0-19.2, p = 0.003). Strong correlations were found between objective cough frequency and both the VAS (day r = 0.80, p < 0.001, night r = 0.71, p = 0.001) and LCQ (r = -0.80, p < 0.001), but not with measures of pulmonary function. Cough rates in IPF were higher than healthy subjects (p < 0.001) and asthma patients (p < 0.001) but similar to patients with chronic cough (p = 0.33).

Conclusions: This study confirms objectively that cough is a major, very distressing and disabling symptom in IPF patients. The strong correlations between objective cough counts and cough related quality of life measures suggest that in IPF patient's, perception of cough frequency is very accurate.

No MeSH data available.


Related in: MedlinePlus

Objective cough frequency (A) and cough VAS scores (B) for day and night in patients with IPF.
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Figure 1: Objective cough frequency (A) and cough VAS scores (B) for day and night in patients with IPF.

Mentions: The overall 24 hour cough rates were high (median 24 hour cough rate 9.4 per hour, range 1.5-39.4), with the day time rates much higher than night time (median 14.6, range 1.9-56.6 compared to 1.9, range 0-19.2, p = 0.003), see figure 1A. Day cough rates moderately correlated with the night time cough rate (r = 0.47, p = 0.04) but neither gender nor age (p = 0.69 and p = 0.33 respectively) were related to cough rates. One analysis in this study was to stratify the data into those who were taking steroids and those who were not and there were no significant differences between the groups (day p = 0.97, night p = 0.71). Patients smoking pack year history also showed no relationship with cough rates (day p = 0.418, night p = 0.533). The first 11 patients were recorded twice to check the reproducibility of the cough measurements (median 11 days apart (IQR 9.25- 40.5)). Bland Altman plots demonstrated cough rates were highly reproducible over time (mean difference in 24hr cough rate 0.3 ± 5.2). In addition, there was very good agreement between the two observers, with a mean difference of only 0.9 (± 1.7) coughs per hour,


Objective cough frequency in Idiopathic Pulmonary Fibrosis.

Key AL, Holt K, Hamilton A, Smith JA, Earis JE - Cough (2010)

Objective cough frequency (A) and cough VAS scores (B) for day and night in patients with IPF.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2902403&req=5

Figure 1: Objective cough frequency (A) and cough VAS scores (B) for day and night in patients with IPF.
Mentions: The overall 24 hour cough rates were high (median 24 hour cough rate 9.4 per hour, range 1.5-39.4), with the day time rates much higher than night time (median 14.6, range 1.9-56.6 compared to 1.9, range 0-19.2, p = 0.003), see figure 1A. Day cough rates moderately correlated with the night time cough rate (r = 0.47, p = 0.04) but neither gender nor age (p = 0.69 and p = 0.33 respectively) were related to cough rates. One analysis in this study was to stratify the data into those who were taking steroids and those who were not and there were no significant differences between the groups (day p = 0.97, night p = 0.71). Patients smoking pack year history also showed no relationship with cough rates (day p = 0.418, night p = 0.533). The first 11 patients were recorded twice to check the reproducibility of the cough measurements (median 11 days apart (IQR 9.25- 40.5)). Bland Altman plots demonstrated cough rates were highly reproducible over time (mean difference in 24hr cough rate 0.3 ± 5.2). In addition, there was very good agreement between the two observers, with a mean difference of only 0.9 (± 1.7) coughs per hour,

Bottom Line: Nineteen IPF patients, mean age 70.8 years +/- 8.6, five female (26.3%) were studied.The 24hr cough rates were high (median 9.4, range 1.5-39.4), with day time rates much higher than night time (median 14.6, range 1.9-56.6 compared to 1.9, range 0-19.2, p = 0.003).Strong correlations were found between objective cough frequency and both the VAS (day r = 0.80, p < 0.001, night r = 0.71, p = 0.001) and LCQ (r = -0.80, p < 0.001), but not with measures of pulmonary function.

View Article: PubMed Central - HTML - PubMed

Affiliation: Respiratory Department, Aintree University Hospitals NHS Foundation Trust, University Hospital Aintree, Longmoor Lane Liverpool, L9 7AL, UK. J.E.Earis@liverpool.ac.uk.

ABSTRACT

Background: Cough is a common presenting symptom in patients with Idiopathic Pulmonary Fibrosis (IPF). This study measured cough rates in IPF patients and investigated the association between cough and measures of health related quality of life and subjective cough assessments. In addition, IPF cough rates were related to measures of physiological disease severity and compared to cough rates in health and other respiratory conditions.

Methods: Nineteen IPF patients, mean age 70.8 years +/- 8.6, five female (26.3%) were studied. Subjects performed full pulmonary function testing, 24 hour ambulatory cough recordings, completed a cough related quality of life questionnaire (Leicester Cough Questionnaire) and subjectively scored cough severity with a visual analogue scale. Ambulatory cough recordings were manually counted and reported as number of coughs per hour.

Results: The 24hr cough rates were high (median 9.4, range 1.5-39.4), with day time rates much higher than night time (median 14.6, range 1.9-56.6 compared to 1.9, range 0-19.2, p = 0.003). Strong correlations were found between objective cough frequency and both the VAS (day r = 0.80, p < 0.001, night r = 0.71, p = 0.001) and LCQ (r = -0.80, p < 0.001), but not with measures of pulmonary function. Cough rates in IPF were higher than healthy subjects (p < 0.001) and asthma patients (p < 0.001) but similar to patients with chronic cough (p = 0.33).

Conclusions: This study confirms objectively that cough is a major, very distressing and disabling symptom in IPF patients. The strong correlations between objective cough counts and cough related quality of life measures suggest that in IPF patient's, perception of cough frequency is very accurate.

No MeSH data available.


Related in: MedlinePlus