Limits...
Primary mammary small-cell carcinoma: A case report and review of the literature.

Haji AG, Sharma S, Vijaykumar DK, Mukherjee P, Babu RM, Chitrathara K - Indian J Med Paediatr Oncol (2009)

Bottom Line: There is a lack of consensus regarding the management of the primary tumor.Present surgical treatment options are similar to those in cases of invasive ductal breast cancer, as appropriate for the size and stage of the lesion.A review of current literature on his rare entity is also presented.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology, Amrita Institute of Medical Sciences and Research Center, Ernakulam, Kerala, India.

ABSTRACT
Only a few cases of primary small-cell carcinoma of the breast have been documented in the current medical literature. A confident diagnosis can only be made if a nonmammary site is excluded or if an in-situ component can be demonstrated histologically. These criteria have been met only in a very few of the published cases, including this case report. We describe a case of a 68-year-old lady with left breast lump, which was diagnosed as breast cancer on fine-needle aspiration and core biopsy. Metastatic workup was negative for disease elsewhere, and she received 3 cycles of neoadjuvant chemotherapy followed by surgery (modified radical mastectomy). However, the disease behaved very aggressively in the postoperative period. There is a lack of consensus regarding the management of the primary tumor. Present surgical treatment options are similar to those in cases of invasive ductal breast cancer, as appropriate for the size and stage of the lesion. A review of current literature on his rare entity is also presented.

No MeSH data available.


Related in: MedlinePlus

High-power view of primary mammary cell carcinoma — H and E stain, (magnification ×200): High-power magnification photomicrograph showing small cells with prominent hyperchromatic nuclei with evenly distributed chromatin, scanty cytoplasm and occasional mitosis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2902213&req=5

Figure 0002: High-power view of primary mammary cell carcinoma — H and E stain, (magnification ×200): High-power magnification photomicrograph showing small cells with prominent hyperchromatic nuclei with evenly distributed chromatin, scanty cytoplasm and occasional mitosis

Mentions: Microscopically, the majority of cells were small with scanty cytoplasm and hyperchromatic nuclei, admixed with occasional nucleoli arranged in nests with a focal cribriform pattern and trabeculae separated by desmoplastic stroma. Mitosis was scanty and necrosis was absent [Figures 1 and 2]. No lymphovascular or perineural invasion was seen. Two areas of in-situ component were also noted showing cells of similar morphology. Immunohistochemistry was negative for neuron-specific enolase, chromogranin and synaptophysin, while it was positive for cytokeratin.


Primary mammary small-cell carcinoma: A case report and review of the literature.

Haji AG, Sharma S, Vijaykumar DK, Mukherjee P, Babu RM, Chitrathara K - Indian J Med Paediatr Oncol (2009)

High-power view of primary mammary cell carcinoma — H and E stain, (magnification ×200): High-power magnification photomicrograph showing small cells with prominent hyperchromatic nuclei with evenly distributed chromatin, scanty cytoplasm and occasional mitosis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2902213&req=5

Figure 0002: High-power view of primary mammary cell carcinoma — H and E stain, (magnification ×200): High-power magnification photomicrograph showing small cells with prominent hyperchromatic nuclei with evenly distributed chromatin, scanty cytoplasm and occasional mitosis
Mentions: Microscopically, the majority of cells were small with scanty cytoplasm and hyperchromatic nuclei, admixed with occasional nucleoli arranged in nests with a focal cribriform pattern and trabeculae separated by desmoplastic stroma. Mitosis was scanty and necrosis was absent [Figures 1 and 2]. No lymphovascular or perineural invasion was seen. Two areas of in-situ component were also noted showing cells of similar morphology. Immunohistochemistry was negative for neuron-specific enolase, chromogranin and synaptophysin, while it was positive for cytokeratin.

Bottom Line: There is a lack of consensus regarding the management of the primary tumor.Present surgical treatment options are similar to those in cases of invasive ductal breast cancer, as appropriate for the size and stage of the lesion.A review of current literature on his rare entity is also presented.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Oncology, Amrita Institute of Medical Sciences and Research Center, Ernakulam, Kerala, India.

ABSTRACT
Only a few cases of primary small-cell carcinoma of the breast have been documented in the current medical literature. A confident diagnosis can only be made if a nonmammary site is excluded or if an in-situ component can be demonstrated histologically. These criteria have been met only in a very few of the published cases, including this case report. We describe a case of a 68-year-old lady with left breast lump, which was diagnosed as breast cancer on fine-needle aspiration and core biopsy. Metastatic workup was negative for disease elsewhere, and she received 3 cycles of neoadjuvant chemotherapy followed by surgery (modified radical mastectomy). However, the disease behaved very aggressively in the postoperative period. There is a lack of consensus regarding the management of the primary tumor. Present surgical treatment options are similar to those in cases of invasive ductal breast cancer, as appropriate for the size and stage of the lesion. A review of current literature on his rare entity is also presented.

No MeSH data available.


Related in: MedlinePlus