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Adrenocortical carcinoma with skeletal metastases in a postmenopausal woman.

Mitra S, Roy SG, Sur PK - Indian J Med Paediatr Oncol (2009)

Bottom Line: In most cases, hormonal investigations reveal an excess secretion of steroids, mostly cortisol and androgens.A 54-year-old lady presented with history of pain in left shoulder and leg for 6 months and features of virilization.The patient has received palliative radiotherapy for the skeletal lesions and 3 cycles of palliative chemotherapy at present.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiotherapy, Medical College Hospital, 88, College Street, Kolkata - 700 073, India.

ABSTRACT
Adrenocortical cancer is a very rare tumor with a poor prognosis. About half of them are hormone-secreting tumors. In most cases, hormonal investigations reveal an excess secretion of steroids, mostly cortisol and androgens. A 54-year-old lady presented with history of pain in left shoulder and leg for 6 months and features of virilization. CT-guided fine-needle aspiration cytology of an abdominal mass revealed the presence of a carcinoma of the left adrenal cortex. A whole-body radionuclide bone scan revealed increased uptake in the left clavicle and left femur. The patient has received palliative radiotherapy for the skeletal lesions and 3 cycles of palliative chemotherapy at present.

No MeSH data available.


Related in: MedlinePlus

Computerized tomography scan of abdomen showing a heterogeneous suprarenal mass on the left side and a heterogeneous space occupying lesion in the liver
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Figure 0004: Computerized tomography scan of abdomen showing a heterogeneous suprarenal mass on the left side and a heterogeneous space occupying lesion in the liver

Mentions: Skiagram of postero-anterior view of the chest revealed a fracture of the left clavicle [Figure 2]. Computerized tomography (CT) scan of the thorax was also advised, but the patient was unable to afford it. X-ray of the left limb showed a circumscribed lytic lesion in the lower shaft of the left femur. A whole-body bone scan (isotopic skeletal survey) with 99 m technetium-methylene diphosphonate revealed abnormally increased uptake over the left clavicle and distal end of left femur [Figure 3]. CT scan of the whole abdomen revealed multiple ill-defined hypodense enhancing space occupying lesions of varying sizes involving both lobes of the liver [Figure 4]. There was a 7.9 × 6.8 cm irregular heterogenous enhancing lesion of the left adrenal gland displacing the upper pole of the left kidney. The adrenal gland of the right side showed no abnormality. There was no retroperitoneal lymphadenopathy. ECG was within normal limits.


Adrenocortical carcinoma with skeletal metastases in a postmenopausal woman.

Mitra S, Roy SG, Sur PK - Indian J Med Paediatr Oncol (2009)

Computerized tomography scan of abdomen showing a heterogeneous suprarenal mass on the left side and a heterogeneous space occupying lesion in the liver
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2902211&req=5

Figure 0004: Computerized tomography scan of abdomen showing a heterogeneous suprarenal mass on the left side and a heterogeneous space occupying lesion in the liver
Mentions: Skiagram of postero-anterior view of the chest revealed a fracture of the left clavicle [Figure 2]. Computerized tomography (CT) scan of the thorax was also advised, but the patient was unable to afford it. X-ray of the left limb showed a circumscribed lytic lesion in the lower shaft of the left femur. A whole-body bone scan (isotopic skeletal survey) with 99 m technetium-methylene diphosphonate revealed abnormally increased uptake over the left clavicle and distal end of left femur [Figure 3]. CT scan of the whole abdomen revealed multiple ill-defined hypodense enhancing space occupying lesions of varying sizes involving both lobes of the liver [Figure 4]. There was a 7.9 × 6.8 cm irregular heterogenous enhancing lesion of the left adrenal gland displacing the upper pole of the left kidney. The adrenal gland of the right side showed no abnormality. There was no retroperitoneal lymphadenopathy. ECG was within normal limits.

Bottom Line: In most cases, hormonal investigations reveal an excess secretion of steroids, mostly cortisol and androgens.A 54-year-old lady presented with history of pain in left shoulder and leg for 6 months and features of virilization.The patient has received palliative radiotherapy for the skeletal lesions and 3 cycles of palliative chemotherapy at present.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiotherapy, Medical College Hospital, 88, College Street, Kolkata - 700 073, India.

ABSTRACT
Adrenocortical cancer is a very rare tumor with a poor prognosis. About half of them are hormone-secreting tumors. In most cases, hormonal investigations reveal an excess secretion of steroids, mostly cortisol and androgens. A 54-year-old lady presented with history of pain in left shoulder and leg for 6 months and features of virilization. CT-guided fine-needle aspiration cytology of an abdominal mass revealed the presence of a carcinoma of the left adrenal cortex. A whole-body radionuclide bone scan revealed increased uptake in the left clavicle and left femur. The patient has received palliative radiotherapy for the skeletal lesions and 3 cycles of palliative chemotherapy at present.

No MeSH data available.


Related in: MedlinePlus