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Synthesis, Characterization, DNA Binding, and Photocleavage Activity of Oxorhenium (V) Complexes with alpha-Diimine and Quinoxaline Ligands.

Mitsopoulou CA, Dagas C - Bioinorg Chem Appl (2010)

Bottom Line: Experimental data suggest that complex 1 intercalates into the DNA base pairs.Upon irradiation, complex 1 was found to promote the cleavage of plasmid pBR 322 DNA from supercoiled form I to nicked form II.The mechanism of the DNA cleavage by complex 1 was also investigated.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Inorganic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Zografou, Athens 157 71, Greece.

ABSTRACT
The complex [ReOCl(3)pq] (1) (where pq = 2-(2'pyridyl)quinoxaline) has been synthesized and fully characterized by UV-Vis, FTIR, 1 and 2D NMR, and cyclic voltammetry (CV). The DNA-binding properties of the complex 1 as well as of the compounds [ReOCl(3)bpy] (2), [ReOCl(3)phen] (3), and pq (4) were investigated by UV-spectrophotometric (melting curves), CV (cyclic voltammetry), and viscosity measurements. Experimental data suggest that complex 1 intercalates into the DNA base pairs. Upon irradiation, complex 1 was found to promote the cleavage of plasmid pBR 322 DNA from supercoiled form I to nicked form II. The mechanism of the DNA cleavage by complex 1 was also investigated.

No MeSH data available.


Structures of the complexes 1–3 and the corresponding α-diimine ligands.
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fig1: Structures of the complexes 1–3 and the corresponding α-diimine ligands.

Mentions: In this paper, we present the synthesis and characterization of the oxorhenium (V) complex, [ReOCl3pq] (1). In order to elucidate the reactivity of this compound, we have also synthesized the complexes [ReOCl3bpy] (2) and [ReOCl3phen] (3) and studied their intercalating abilities. The ligands (2′pyridyl)quinoxaline (4), 2,2′ bipyridine (5), and 1-10-phenanthroline (6) belong to quinoxaline or diimine class of organic compounds (Figure 1).


Synthesis, Characterization, DNA Binding, and Photocleavage Activity of Oxorhenium (V) Complexes with alpha-Diimine and Quinoxaline Ligands.

Mitsopoulou CA, Dagas C - Bioinorg Chem Appl (2010)

Structures of the complexes 1–3 and the corresponding α-diimine ligands.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2902146&req=5

fig1: Structures of the complexes 1–3 and the corresponding α-diimine ligands.
Mentions: In this paper, we present the synthesis and characterization of the oxorhenium (V) complex, [ReOCl3pq] (1). In order to elucidate the reactivity of this compound, we have also synthesized the complexes [ReOCl3bpy] (2) and [ReOCl3phen] (3) and studied their intercalating abilities. The ligands (2′pyridyl)quinoxaline (4), 2,2′ bipyridine (5), and 1-10-phenanthroline (6) belong to quinoxaline or diimine class of organic compounds (Figure 1).

Bottom Line: Experimental data suggest that complex 1 intercalates into the DNA base pairs.Upon irradiation, complex 1 was found to promote the cleavage of plasmid pBR 322 DNA from supercoiled form I to nicked form II.The mechanism of the DNA cleavage by complex 1 was also investigated.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Inorganic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Zografou, Athens 157 71, Greece.

ABSTRACT
The complex [ReOCl(3)pq] (1) (where pq = 2-(2'pyridyl)quinoxaline) has been synthesized and fully characterized by UV-Vis, FTIR, 1 and 2D NMR, and cyclic voltammetry (CV). The DNA-binding properties of the complex 1 as well as of the compounds [ReOCl(3)bpy] (2), [ReOCl(3)phen] (3), and pq (4) were investigated by UV-spectrophotometric (melting curves), CV (cyclic voltammetry), and viscosity measurements. Experimental data suggest that complex 1 intercalates into the DNA base pairs. Upon irradiation, complex 1 was found to promote the cleavage of plasmid pBR 322 DNA from supercoiled form I to nicked form II. The mechanism of the DNA cleavage by complex 1 was also investigated.

No MeSH data available.