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Surgical treatment by partial petrosectomy for a middle-ear carcinoid with progressive extension: a case report and review of the literature.

Aoki M, Mizuta K, Ueda N, Yamada N, Ito Y, Kato H, Hirose Y - Int J Otolaryngol (2010)

Bottom Line: The CT and dynamic MRI demonstrated an extensive tumor close to the carotid artery canal and the jugular bulb, and the tumor was removed by a partial petrosectomy with a transmastoid approach.The histopathological findings revealed a solid and trabecular tumor with cells positive for cytokeratin, chromogranin A, synaptophysin, and CD56.The relevant literature is reviewed in regard to the present case.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City 501-1194, Japan.

ABSTRACT
We herein report a 59-year-old male patient with a recurrent carcinoid tumor of the middle ear 7 years after a tympanomastoidectomy. The CT and dynamic MRI demonstrated an extensive tumor close to the carotid artery canal and the jugular bulb, and the tumor was removed by a partial petrosectomy with a transmastoid approach. The histopathological findings revealed a solid and trabecular tumor with cells positive for cytokeratin, chromogranin A, synaptophysin, and CD56. The MIB-1 antibody for the Ki-67 antigen was positive in 6.6% of the tumor cells. The relevant literature is reviewed in regard to the present case.

No MeSH data available.


Related in: MedlinePlus

Pathological findings. The histopathological findings revealed a solid tubuloglandular pattern, resembling an adenomatous tumor of the middle ear ((a) examination on low power).   One cell type, the A-type cells lining the glandular lumina, was observed with a lower frequency.  These slender darkly staining cells had the appearance of endothelial cells.  The other cells, the B-type cells, were observed in glandular structures and were characterized by a round or oval nucleus and an abundant, pale cytoplasm ((b) examination on high power).  The B-type cells were typically positive for cytokeratin, chromogranin A, and synaptophysin, and 6.6% of the carcinoid tumor cells were positive for MIB-1 staining.
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fig3: Pathological findings. The histopathological findings revealed a solid tubuloglandular pattern, resembling an adenomatous tumor of the middle ear ((a) examination on low power). One cell type, the A-type cells lining the glandular lumina, was observed with a lower frequency. These slender darkly staining cells had the appearance of endothelial cells. The other cells, the B-type cells, were observed in glandular structures and were characterized by a round or oval nucleus and an abundant, pale cytoplasm ((b) examination on high power). The B-type cells were typically positive for cytokeratin, chromogranin A, and synaptophysin, and 6.6% of the carcinoid tumor cells were positive for MIB-1 staining.

Mentions: The histopathological findings showed a solid sheet of homogenous cells, which was surrounded by a fibrous border. The tumor cells had round, oval, or slightly irregular nuclei with finely-dispersed chromatin, and occasionally formed glandular or tubular structures (Figures 3(a) and 3(b)). They were typically positive for cytokeratin, chromogranin A, synaptophysin, and CD56, but were negative for S-100. The proliferative capacity of the tumor cells was assessed by observing the cells expressing the marker MIB-1, which is an antibody against antigen Ki-67. This was used to calculate the proliferation index for each tumor lesion by counting the total number of tumor cell nuclear profiles and the number of MIB-1-positive nuclear profiles in randomly and systematically selected fields. The first field in each tumor lesion was selected randomly, and the following fields were sampled systematically using a mesh [6]. The positive rate of MIB-1 was 6.6% (Figure 3). The tumor was diagnosed as carcinoid tumor based on these pathological findings.


Surgical treatment by partial petrosectomy for a middle-ear carcinoid with progressive extension: a case report and review of the literature.

Aoki M, Mizuta K, Ueda N, Yamada N, Ito Y, Kato H, Hirose Y - Int J Otolaryngol (2010)

Pathological findings. The histopathological findings revealed a solid tubuloglandular pattern, resembling an adenomatous tumor of the middle ear ((a) examination on low power).   One cell type, the A-type cells lining the glandular lumina, was observed with a lower frequency.  These slender darkly staining cells had the appearance of endothelial cells.  The other cells, the B-type cells, were observed in glandular structures and were characterized by a round or oval nucleus and an abundant, pale cytoplasm ((b) examination on high power).  The B-type cells were typically positive for cytokeratin, chromogranin A, and synaptophysin, and 6.6% of the carcinoid tumor cells were positive for MIB-1 staining.
© Copyright Policy - open-access
Related In: Results  -  Collection

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fig3: Pathological findings. The histopathological findings revealed a solid tubuloglandular pattern, resembling an adenomatous tumor of the middle ear ((a) examination on low power). One cell type, the A-type cells lining the glandular lumina, was observed with a lower frequency. These slender darkly staining cells had the appearance of endothelial cells. The other cells, the B-type cells, were observed in glandular structures and were characterized by a round or oval nucleus and an abundant, pale cytoplasm ((b) examination on high power). The B-type cells were typically positive for cytokeratin, chromogranin A, and synaptophysin, and 6.6% of the carcinoid tumor cells were positive for MIB-1 staining.
Mentions: The histopathological findings showed a solid sheet of homogenous cells, which was surrounded by a fibrous border. The tumor cells had round, oval, or slightly irregular nuclei with finely-dispersed chromatin, and occasionally formed glandular or tubular structures (Figures 3(a) and 3(b)). They were typically positive for cytokeratin, chromogranin A, synaptophysin, and CD56, but were negative for S-100. The proliferative capacity of the tumor cells was assessed by observing the cells expressing the marker MIB-1, which is an antibody against antigen Ki-67. This was used to calculate the proliferation index for each tumor lesion by counting the total number of tumor cell nuclear profiles and the number of MIB-1-positive nuclear profiles in randomly and systematically selected fields. The first field in each tumor lesion was selected randomly, and the following fields were sampled systematically using a mesh [6]. The positive rate of MIB-1 was 6.6% (Figure 3). The tumor was diagnosed as carcinoid tumor based on these pathological findings.

Bottom Line: The CT and dynamic MRI demonstrated an extensive tumor close to the carotid artery canal and the jugular bulb, and the tumor was removed by a partial petrosectomy with a transmastoid approach.The histopathological findings revealed a solid and trabecular tumor with cells positive for cytokeratin, chromogranin A, synaptophysin, and CD56.The relevant literature is reviewed in regard to the present case.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City 501-1194, Japan.

ABSTRACT
We herein report a 59-year-old male patient with a recurrent carcinoid tumor of the middle ear 7 years after a tympanomastoidectomy. The CT and dynamic MRI demonstrated an extensive tumor close to the carotid artery canal and the jugular bulb, and the tumor was removed by a partial petrosectomy with a transmastoid approach. The histopathological findings revealed a solid and trabecular tumor with cells positive for cytokeratin, chromogranin A, synaptophysin, and CD56. The MIB-1 antibody for the Ki-67 antigen was positive in 6.6% of the tumor cells. The relevant literature is reviewed in regard to the present case.

No MeSH data available.


Related in: MedlinePlus