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Antibacterial activities of a new brominated diterpene from Borneon Laurencia spp.

Vairappan CS, Ishii T, Lee TK, Suzuki M, Zhaoqi Z - Mar Drugs (2010)

Bottom Line: In our continuous interest to study the diversity of halogenated metabolites of Malaysian species of the red algal genus Laurencia, we examined the chemical composition of five populations of unrecorded Laurencia sp.A new brominated diterpene, 10-acetoxyangasiol (1), and four other known metabolites, aplysidiol (2), cupalaurenol (3), 1-methyl-2,3,5-tribromoindole (4), and chamigrane epoxide (5), were isolated and identified.Isolated metabolites exhibited potent antibacterial activities against clinical bacteria, Staphylococcus aureus, Staphylococcus sp., Streptococcus pyogenes, Salmonella sp. and Vibrio cholerae.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia. csv@ums.edu.my

ABSTRACT
In our continuous interest to study the diversity of halogenated metabolites of Malaysian species of the red algal genus Laurencia, we examined the chemical composition of five populations of unrecorded Laurencia sp. A new brominated diterpene, 10-acetoxyangasiol (1), and four other known metabolites, aplysidiol (2), cupalaurenol (3), 1-methyl-2,3,5-tribromoindole (4), and chamigrane epoxide (5), were isolated and identified. Isolated metabolites exhibited potent antibacterial activities against clinical bacteria, Staphylococcus aureus, Staphylococcus sp., Streptococcus pyogenes, Salmonella sp. and Vibrio cholerae.

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Related in: MedlinePlus

The structure of compounds 1–5 from specimens of algae Laurencia sp.
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f1-marinedrugs-08-01743: The structure of compounds 1–5 from specimens of algae Laurencia sp.

Mentions: The partially dried specimens of algae Laurencia sp. were extracted in MeOH (1:1, v/v). The concentrated extracts were partitioned between H2O and EtOAc. The EtOAc soluble fraction was dehydrated over Na2SO4 anhydrous, filtered, concentrated and purified by a combination of silica gel column chromatography and High Performance Liquid Chromatography (HPLC) separation, to yield compounds 1–5 (Figure 1).


Antibacterial activities of a new brominated diterpene from Borneon Laurencia spp.

Vairappan CS, Ishii T, Lee TK, Suzuki M, Zhaoqi Z - Mar Drugs (2010)

The structure of compounds 1–5 from specimens of algae Laurencia sp.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC2901821&req=5

f1-marinedrugs-08-01743: The structure of compounds 1–5 from specimens of algae Laurencia sp.
Mentions: The partially dried specimens of algae Laurencia sp. were extracted in MeOH (1:1, v/v). The concentrated extracts were partitioned between H2O and EtOAc. The EtOAc soluble fraction was dehydrated over Na2SO4 anhydrous, filtered, concentrated and purified by a combination of silica gel column chromatography and High Performance Liquid Chromatography (HPLC) separation, to yield compounds 1–5 (Figure 1).

Bottom Line: In our continuous interest to study the diversity of halogenated metabolites of Malaysian species of the red algal genus Laurencia, we examined the chemical composition of five populations of unrecorded Laurencia sp.A new brominated diterpene, 10-acetoxyangasiol (1), and four other known metabolites, aplysidiol (2), cupalaurenol (3), 1-methyl-2,3,5-tribromoindole (4), and chamigrane epoxide (5), were isolated and identified.Isolated metabolites exhibited potent antibacterial activities against clinical bacteria, Staphylococcus aureus, Staphylococcus sp., Streptococcus pyogenes, Salmonella sp. and Vibrio cholerae.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia. csv@ums.edu.my

ABSTRACT
In our continuous interest to study the diversity of halogenated metabolites of Malaysian species of the red algal genus Laurencia, we examined the chemical composition of five populations of unrecorded Laurencia sp. A new brominated diterpene, 10-acetoxyangasiol (1), and four other known metabolites, aplysidiol (2), cupalaurenol (3), 1-methyl-2,3,5-tribromoindole (4), and chamigrane epoxide (5), were isolated and identified. Isolated metabolites exhibited potent antibacterial activities against clinical bacteria, Staphylococcus aureus, Staphylococcus sp., Streptococcus pyogenes, Salmonella sp. and Vibrio cholerae.

Show MeSH
Related in: MedlinePlus