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Energy expenditure in Japanese patients with severe or moderate ulcerative colitis.

Sasaki M, Johtatsu T, Kurihara M, Iwakawa H, Tanaka T, Bamba S, Tsujikawa T, Fujiyama Y, Andoh A - J Clin Biochem Nutr (2010)

Bottom Line: In the UC patients, a significant correlation was observed between the mREEs and the clinical activity index.In conclusion, UC patients showed a hyper-metabolic status as evaluated by their mREE/body weight.Energy expenditure was significantly correlated with disease activity.

View Article: PubMed Central - PubMed

Affiliation: Division of Clinical Nutrition, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga 520-2192, Japan.

ABSTRACT
We investigated the energy expenditure in hospitalized patients with severe or moderate ulcerative colitis (UC), and compared them to healthy controls. Thirteen patients (5 women and 8 men; mean age 31.8 years; mean BMI 19.0 kg/m(2)) and 10 healthy volunteers were enrolled in this study. The resting energy expenditure (mREE) levels were determined by indirect calorimetry. The mREEs of the UC patients were significantly higher than those of healthy controls (26.4 +/- 3.6 vs 21.8 +/- 1.7 kcal/kg/day), although the mREEs of the UC patients were almost the same as the predicted REEs (pREEs) calculated by the Harris-Benedict equation (26.4 +/- 2.4 kcal/kg/day vs 26.5 +/- 2.6 kcal/kg/day). The mREE/pREE ratio, which reflects stress, was 1.0 +/- 0.15. In the UC patients, a significant correlation was observed between the mREEs and the clinical activity index. In conclusion, UC patients showed a hyper-metabolic status as evaluated by their mREE/body weight. Energy expenditure was significantly correlated with disease activity. From our observations, we recommend that nutritional management with more than 30-35 kcal/ideal body weight/day (calculated by the mREE x activity factor) may be optimal for active severe or moderate ulcerative colitis.

No MeSH data available.


Related in: MedlinePlus

Correlation between the measured resting energy expenditure (mREE) and the predicted resting energy expenditure (pREE). The mREE was measured by indirect calorimetry, and the pREE was calculated by the Harris-Benedict equation. There was a positive correlation between the mREE and pREE in UC patients.
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Figure 1: Correlation between the measured resting energy expenditure (mREE) and the predicted resting energy expenditure (pREE). The mREE was measured by indirect calorimetry, and the pREE was calculated by the Harris-Benedict equation. There was a positive correlation between the mREE and pREE in UC patients.

Mentions: In UC patients, the pREE calculated by the Harris-Benedict equation was 1407.0 ± 154.0 kcal/day, and there was a positive correlation between the pREE and mREE (p<0.05) (Fig. 1). Similar observations were noted in the controls (p<0.01). The mREE/pREE ratio in the UC patients (1.00 ± 0.15) was higher than in the controls (0.94 ± 0.10) (Table 2), but not significant.


Energy expenditure in Japanese patients with severe or moderate ulcerative colitis.

Sasaki M, Johtatsu T, Kurihara M, Iwakawa H, Tanaka T, Bamba S, Tsujikawa T, Fujiyama Y, Andoh A - J Clin Biochem Nutr (2010)

Correlation between the measured resting energy expenditure (mREE) and the predicted resting energy expenditure (pREE). The mREE was measured by indirect calorimetry, and the pREE was calculated by the Harris-Benedict equation. There was a positive correlation between the mREE and pREE in UC patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2901761&req=5

Figure 1: Correlation between the measured resting energy expenditure (mREE) and the predicted resting energy expenditure (pREE). The mREE was measured by indirect calorimetry, and the pREE was calculated by the Harris-Benedict equation. There was a positive correlation between the mREE and pREE in UC patients.
Mentions: In UC patients, the pREE calculated by the Harris-Benedict equation was 1407.0 ± 154.0 kcal/day, and there was a positive correlation between the pREE and mREE (p<0.05) (Fig. 1). Similar observations were noted in the controls (p<0.01). The mREE/pREE ratio in the UC patients (1.00 ± 0.15) was higher than in the controls (0.94 ± 0.10) (Table 2), but not significant.

Bottom Line: In the UC patients, a significant correlation was observed between the mREEs and the clinical activity index.In conclusion, UC patients showed a hyper-metabolic status as evaluated by their mREE/body weight.Energy expenditure was significantly correlated with disease activity.

View Article: PubMed Central - PubMed

Affiliation: Division of Clinical Nutrition, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga 520-2192, Japan.

ABSTRACT
We investigated the energy expenditure in hospitalized patients with severe or moderate ulcerative colitis (UC), and compared them to healthy controls. Thirteen patients (5 women and 8 men; mean age 31.8 years; mean BMI 19.0 kg/m(2)) and 10 healthy volunteers were enrolled in this study. The resting energy expenditure (mREE) levels were determined by indirect calorimetry. The mREEs of the UC patients were significantly higher than those of healthy controls (26.4 +/- 3.6 vs 21.8 +/- 1.7 kcal/kg/day), although the mREEs of the UC patients were almost the same as the predicted REEs (pREEs) calculated by the Harris-Benedict equation (26.4 +/- 2.4 kcal/kg/day vs 26.5 +/- 2.6 kcal/kg/day). The mREE/pREE ratio, which reflects stress, was 1.0 +/- 0.15. In the UC patients, a significant correlation was observed between the mREEs and the clinical activity index. In conclusion, UC patients showed a hyper-metabolic status as evaluated by their mREE/body weight. Energy expenditure was significantly correlated with disease activity. From our observations, we recommend that nutritional management with more than 30-35 kcal/ideal body weight/day (calculated by the mREE x activity factor) may be optimal for active severe or moderate ulcerative colitis.

No MeSH data available.


Related in: MedlinePlus