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Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine.

Kljun J, Petricek S, Zigon D, Hudej R, Miklavcic D, Turel I - Bioinorg Chem Appl (2010)

Bottom Line: Novel ruthenium(III) complexes with histamine [RuCl(4)(dmso-S)(histamineH)] .H( (2) )O (1a) and [RuCl(4)(dmso-S)(histamineH)] (1b) have been prepared and characterized by X-ray structure analysis.Their crystal structures are similar and show a protonated amino group on the side chain of the ligand which is not very common for a simple heterocyclic derivative such as histamine.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Chemistry and Chemical Technology, University of Ljubljana, Askerceva 5, 1000 Ljubljana, Slovenia.

ABSTRACT
Novel ruthenium(III) complexes with histamine [RuCl(4)(dmso-S)(histamineH)] . H( (2) )O (1a) and [RuCl(4)(dmso-S)(histamineH)] (1b) have been prepared and characterized by X-ray structure analysis. Their crystal structures are similar and show a protonated amino group on the side chain of the ligand which is not very common for a simple heterocyclic derivative such as histamine. Biological assays to test the cytotoxicity of the compound 1b combined with electroporation were performed to determine its potential for future medical applications in cancer treatment.

No MeSH data available.


NAMI-A and KP1019.
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sch1: NAMI-A and KP1019.


Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine.

Kljun J, Petricek S, Zigon D, Hudej R, Miklavcic D, Turel I - Bioinorg Chem Appl (2010)

NAMI-A and KP1019.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2901621&req=5

sch1: NAMI-A and KP1019.
Bottom Line: Novel ruthenium(III) complexes with histamine [RuCl(4)(dmso-S)(histamineH)] .H( (2) )O (1a) and [RuCl(4)(dmso-S)(histamineH)] (1b) have been prepared and characterized by X-ray structure analysis.Their crystal structures are similar and show a protonated amino group on the side chain of the ligand which is not very common for a simple heterocyclic derivative such as histamine.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Chemistry and Chemical Technology, University of Ljubljana, Askerceva 5, 1000 Ljubljana, Slovenia.

ABSTRACT
Novel ruthenium(III) complexes with histamine [RuCl(4)(dmso-S)(histamineH)] . H( (2) )O (1a) and [RuCl(4)(dmso-S)(histamineH)] (1b) have been prepared and characterized by X-ray structure analysis. Their crystal structures are similar and show a protonated amino group on the side chain of the ligand which is not very common for a simple heterocyclic derivative such as histamine. Biological assays to test the cytotoxicity of the compound 1b combined with electroporation were performed to determine its potential for future medical applications in cancer treatment.

No MeSH data available.