Limits...
"Lantern-Shaped" Platinum(III) Complexes with Axially Bound 9-Ethylguanine or 1-Methylcytosine (L) of General Formula [Pt(2){HN=C(Bu)O}(4)L(2)](NO(3))(2).

Pacifico C, Intini FP, Nushi F, Natile G - Bioinorg Chem Appl (2010)

Bottom Line: The synthesis, NMR characterization, and X-ray crystallography of "lantern-shaped" platinum(III) complexes with four pivaloamidate bridging ligands and two 9-ethylguanines (9-EtG) or 1-methylcytosines (1-MeC) in axial positions are reported: cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(9-EtG)(2)](NO(3))(2) and cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(1-MeC)(2)](NO(3))(2).The last complex is, to the best of our knowledge, the first dinuclear compound of platinum(III) with axially bound 1-MeC.

View Article: PubMed Central - PubMed

Affiliation: Dipartimento Farmaco-Chimico, Università degli Studi di Bari, Via E. Orabona 4, 70125 Bari, Italy.

ABSTRACT
The synthesis, NMR characterization, and X-ray crystallography of "lantern-shaped" platinum(III) complexes with four pivaloamidate bridging ligands and two 9-ethylguanines (9-EtG) or 1-methylcytosines (1-MeC) in axial positions are reported: cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(9-EtG)(2)](NO(3))(2) and cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(1-MeC)(2)](NO(3))(2). The last complex is, to the best of our knowledge, the first dinuclear compound of platinum(III) with axially bound 1-MeC.

No MeSH data available.


View of the crystal packing along the a direction for [Pt2{HN=C(But)O}4(1-MeC)2](NO3)2·2(1,4-dioxane). Since the tert-butyl groups and the dioxane molecules are disordered, only one occupation site is shown for clarity.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2901605&req=5

fig4: View of the crystal packing along the a direction for [Pt2{HN=C(But)O}4(1-MeC)2](NO3)2·2(1,4-dioxane). Since the tert-butyl groups and the dioxane molecules are disordered, only one occupation site is shown for clarity.

Mentions: As expected, the axial Pt(III)–N3c bond length (2.230(5) Å) is longer than that observed in 4-coordinate platinum(II) and 6-coordinate platinum(IV) complexes with cytosine (~2.025–2.082 Å) [45, 47, 56–58]. It is to be noted that the Pt–N3c distance is slightly longer than the Pt–N7g distance observed in compound 1. The cytosine plane bisects the angle between two adjacent pivaloamidate planes forming a C2c–N3c–Pt–N1 torsion angle of 44°. This allows the formation of bifurcated hydrogen bonds between N4 of 1-MeC and the O atoms of two amidate ligands (N4c ⋯ O1 = 2.92(1) Å, (N4c)H41c ⋯ O1 = 2.30(1) Å, N4c–H41c ⋯ O1 = 130(1)°; N4c ⋯ O2 = 2.93(1) Å, (N4c)H41c ⋯ O2 = 2.31(1) Å, N4c–H41c ⋯ O2 = 130(1)°) [59]. Each nitrate anion (nitrate oxygens O6, O7, and O8) is anchored to one 1-MeC through a hydrogen bond (N4c ⋯ O8 = 2.85(1) Å, (N4c)H42c ⋯ O8 = 2.00(1) Å, N4c–H42c ⋯ O8 = 167(1)°, Figure 4).


"Lantern-Shaped" Platinum(III) Complexes with Axially Bound 9-Ethylguanine or 1-Methylcytosine (L) of General Formula [Pt(2){HN=C(Bu)O}(4)L(2)](NO(3))(2).

Pacifico C, Intini FP, Nushi F, Natile G - Bioinorg Chem Appl (2010)

View of the crystal packing along the a direction for [Pt2{HN=C(But)O}4(1-MeC)2](NO3)2·2(1,4-dioxane). Since the tert-butyl groups and the dioxane molecules are disordered, only one occupation site is shown for clarity.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2901605&req=5

fig4: View of the crystal packing along the a direction for [Pt2{HN=C(But)O}4(1-MeC)2](NO3)2·2(1,4-dioxane). Since the tert-butyl groups and the dioxane molecules are disordered, only one occupation site is shown for clarity.
Mentions: As expected, the axial Pt(III)–N3c bond length (2.230(5) Å) is longer than that observed in 4-coordinate platinum(II) and 6-coordinate platinum(IV) complexes with cytosine (~2.025–2.082 Å) [45, 47, 56–58]. It is to be noted that the Pt–N3c distance is slightly longer than the Pt–N7g distance observed in compound 1. The cytosine plane bisects the angle between two adjacent pivaloamidate planes forming a C2c–N3c–Pt–N1 torsion angle of 44°. This allows the formation of bifurcated hydrogen bonds between N4 of 1-MeC and the O atoms of two amidate ligands (N4c ⋯ O1 = 2.92(1) Å, (N4c)H41c ⋯ O1 = 2.30(1) Å, N4c–H41c ⋯ O1 = 130(1)°; N4c ⋯ O2 = 2.93(1) Å, (N4c)H41c ⋯ O2 = 2.31(1) Å, N4c–H41c ⋯ O2 = 130(1)°) [59]. Each nitrate anion (nitrate oxygens O6, O7, and O8) is anchored to one 1-MeC through a hydrogen bond (N4c ⋯ O8 = 2.85(1) Å, (N4c)H42c ⋯ O8 = 2.00(1) Å, N4c–H42c ⋯ O8 = 167(1)°, Figure 4).

Bottom Line: The synthesis, NMR characterization, and X-ray crystallography of "lantern-shaped" platinum(III) complexes with four pivaloamidate bridging ligands and two 9-ethylguanines (9-EtG) or 1-methylcytosines (1-MeC) in axial positions are reported: cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(9-EtG)(2)](NO(3))(2) and cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(1-MeC)(2)](NO(3))(2).The last complex is, to the best of our knowledge, the first dinuclear compound of platinum(III) with axially bound 1-MeC.

View Article: PubMed Central - PubMed

Affiliation: Dipartimento Farmaco-Chimico, Università degli Studi di Bari, Via E. Orabona 4, 70125 Bari, Italy.

ABSTRACT
The synthesis, NMR characterization, and X-ray crystallography of "lantern-shaped" platinum(III) complexes with four pivaloamidate bridging ligands and two 9-ethylguanines (9-EtG) or 1-methylcytosines (1-MeC) in axial positions are reported: cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(9-EtG)(2)](NO(3))(2) and cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(1-MeC)(2)](NO(3))(2). The last complex is, to the best of our knowledge, the first dinuclear compound of platinum(III) with axially bound 1-MeC.

No MeSH data available.