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"Lantern-Shaped" Platinum(III) Complexes with Axially Bound 9-Ethylguanine or 1-Methylcytosine (L) of General Formula [Pt(2){HN=C(Bu)O}(4)L(2)](NO(3))(2).

Pacifico C, Intini FP, Nushi F, Natile G - Bioinorg Chem Appl (2010)

Bottom Line: The synthesis, NMR characterization, and X-ray crystallography of "lantern-shaped" platinum(III) complexes with four pivaloamidate bridging ligands and two 9-ethylguanines (9-EtG) or 1-methylcytosines (1-MeC) in axial positions are reported: cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(9-EtG)(2)](NO(3))(2) and cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(1-MeC)(2)](NO(3))(2).The last complex is, to the best of our knowledge, the first dinuclear compound of platinum(III) with axially bound 1-MeC.

View Article: PubMed Central - PubMed

Affiliation: Dipartimento Farmaco-Chimico, Università degli Studi di Bari, Via E. Orabona 4, 70125 Bari, Italy.

ABSTRACT
The synthesis, NMR characterization, and X-ray crystallography of "lantern-shaped" platinum(III) complexes with four pivaloamidate bridging ligands and two 9-ethylguanines (9-EtG) or 1-methylcytosines (1-MeC) in axial positions are reported: cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(9-EtG)(2)](NO(3))(2) and cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(1-MeC)(2)](NO(3))(2). The last complex is, to the best of our knowledge, the first dinuclear compound of platinum(III) with axially bound 1-MeC.

No MeSH data available.


View of the [Pt2{HN=C(But)O}4(1-MeC)2]2+ complex showing the atomic numbering scheme of most important atoms. The tert-butyl groups are disordered and can occupy two different positions; only one position is shown for clarity. Displacement ellipsoids are drawn at 20% probability level.
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fig3: View of the [Pt2{HN=C(But)O}4(1-MeC)2]2+ complex showing the atomic numbering scheme of most important atoms. The tert-butyl groups are disordered and can occupy two different positions; only one position is shown for clarity. Displacement ellipsoids are drawn at 20% probability level.

Mentions: Compound 2 crystallizes incorporating two molecules of 1,4-dioxane per molecule of complex. The asymmetric unit comprises half molecule of complex and one of dioxane and the structure is generated by inversion at the midpoint of the Pt–Pt linkage (Figure 3). Each Pt(III) atom has a distorted octahedral geometry with the N3 of 1-MeC and the second platinum subunit in axial positions.


"Lantern-Shaped" Platinum(III) Complexes with Axially Bound 9-Ethylguanine or 1-Methylcytosine (L) of General Formula [Pt(2){HN=C(Bu)O}(4)L(2)](NO(3))(2).

Pacifico C, Intini FP, Nushi F, Natile G - Bioinorg Chem Appl (2010)

View of the [Pt2{HN=C(But)O}4(1-MeC)2]2+ complex showing the atomic numbering scheme of most important atoms. The tert-butyl groups are disordered and can occupy two different positions; only one position is shown for clarity. Displacement ellipsoids are drawn at 20% probability level.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2901605&req=5

fig3: View of the [Pt2{HN=C(But)O}4(1-MeC)2]2+ complex showing the atomic numbering scheme of most important atoms. The tert-butyl groups are disordered and can occupy two different positions; only one position is shown for clarity. Displacement ellipsoids are drawn at 20% probability level.
Mentions: Compound 2 crystallizes incorporating two molecules of 1,4-dioxane per molecule of complex. The asymmetric unit comprises half molecule of complex and one of dioxane and the structure is generated by inversion at the midpoint of the Pt–Pt linkage (Figure 3). Each Pt(III) atom has a distorted octahedral geometry with the N3 of 1-MeC and the second platinum subunit in axial positions.

Bottom Line: The synthesis, NMR characterization, and X-ray crystallography of "lantern-shaped" platinum(III) complexes with four pivaloamidate bridging ligands and two 9-ethylguanines (9-EtG) or 1-methylcytosines (1-MeC) in axial positions are reported: cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(9-EtG)(2)](NO(3))(2) and cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(1-MeC)(2)](NO(3))(2).The last complex is, to the best of our knowledge, the first dinuclear compound of platinum(III) with axially bound 1-MeC.

View Article: PubMed Central - PubMed

Affiliation: Dipartimento Farmaco-Chimico, Università degli Studi di Bari, Via E. Orabona 4, 70125 Bari, Italy.

ABSTRACT
The synthesis, NMR characterization, and X-ray crystallography of "lantern-shaped" platinum(III) complexes with four pivaloamidate bridging ligands and two 9-ethylguanines (9-EtG) or 1-methylcytosines (1-MeC) in axial positions are reported: cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(9-EtG)(2)](NO(3))(2) and cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(1-MeC)(2)](NO(3))(2). The last complex is, to the best of our knowledge, the first dinuclear compound of platinum(III) with axially bound 1-MeC.

No MeSH data available.