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Ghrelin increases intake of rewarding food in rodents.

Egecioglu E, Jerlhag E, Salomé N, Skibicka KP, Haage D, Bohlooly-Y M, Andersson D, Bjursell M, Perrissoud D, Engel JA, Dickson SL - Addict Biol (2010)

Bottom Line: Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice.Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow.Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology/Endocrinology, The Sahlgrenska Academy at the University of Gothenburg, SE-405 30 Gothenburg, Sweden. emil.egecioglu@medic.gu.se

ABSTRACT
We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of rewarding food in a free choice (chow/rewarding food) paradigm. Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice. Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow. In comparison with sham rats, VTA-lesioned rats had normal intracerebroventricular ghrelin-induced chow intake, although both intake of and time spent exploring rewarding food was decreased. Finally, the ability of rewarding food to condition a place preference was suppressed by the GHS-R1A antagonist in rats. Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.

Show MeSH
Effects of intra-ventral tegmental area (VTA) injections of ghrelin or vehicle on 60 minutes locomotor activity and feeding in mice exposed to different kinds of foods. Bilateral intra-VTA administration of ghrelin increased both (a) locomotor activity in the presence of both chow and peanut butter and (b) the intake of peanut butter but not chow compared with vehicle administration. n = 8 for all groups (a) ***P < 0.001, effect of treatment two-way analysis of variance (ANOVA) (b) **P < 0.01, ***P < 0.001, two-way ANOVA followed by Bonferroni post-hoc test
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fig04: Effects of intra-ventral tegmental area (VTA) injections of ghrelin or vehicle on 60 minutes locomotor activity and feeding in mice exposed to different kinds of foods. Bilateral intra-VTA administration of ghrelin increased both (a) locomotor activity in the presence of both chow and peanut butter and (b) the intake of peanut butter but not chow compared with vehicle administration. n = 8 for all groups (a) ***P < 0.001, effect of treatment two-way analysis of variance (ANOVA) (b) **P < 0.01, ***P < 0.001, two-way ANOVA followed by Bonferroni post-hoc test

Mentions: Intra-VTA administration of ghrelin to NMRI mice increased 60 minutes locomotor activity in the presence of either standard chow or peanut butter (both P < 0.001, Fig. 4a). However, intra-VTA ghrelin administration increased caloric intake relative to vehicle treatment only in mice fed with peanut butter and not in mice fed with standard chow (P < 0.001, Fig. 4b).


Ghrelin increases intake of rewarding food in rodents.

Egecioglu E, Jerlhag E, Salomé N, Skibicka KP, Haage D, Bohlooly-Y M, Andersson D, Bjursell M, Perrissoud D, Engel JA, Dickson SL - Addict Biol (2010)

Effects of intra-ventral tegmental area (VTA) injections of ghrelin or vehicle on 60 minutes locomotor activity and feeding in mice exposed to different kinds of foods. Bilateral intra-VTA administration of ghrelin increased both (a) locomotor activity in the presence of both chow and peanut butter and (b) the intake of peanut butter but not chow compared with vehicle administration. n = 8 for all groups (a) ***P < 0.001, effect of treatment two-way analysis of variance (ANOVA) (b) **P < 0.01, ***P < 0.001, two-way ANOVA followed by Bonferroni post-hoc test
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2901520&req=5

fig04: Effects of intra-ventral tegmental area (VTA) injections of ghrelin or vehicle on 60 minutes locomotor activity and feeding in mice exposed to different kinds of foods. Bilateral intra-VTA administration of ghrelin increased both (a) locomotor activity in the presence of both chow and peanut butter and (b) the intake of peanut butter but not chow compared with vehicle administration. n = 8 for all groups (a) ***P < 0.001, effect of treatment two-way analysis of variance (ANOVA) (b) **P < 0.01, ***P < 0.001, two-way ANOVA followed by Bonferroni post-hoc test
Mentions: Intra-VTA administration of ghrelin to NMRI mice increased 60 minutes locomotor activity in the presence of either standard chow or peanut butter (both P < 0.001, Fig. 4a). However, intra-VTA ghrelin administration increased caloric intake relative to vehicle treatment only in mice fed with peanut butter and not in mice fed with standard chow (P < 0.001, Fig. 4b).

Bottom Line: Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice.Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow.Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology/Endocrinology, The Sahlgrenska Academy at the University of Gothenburg, SE-405 30 Gothenburg, Sweden. emil.egecioglu@medic.gu.se

ABSTRACT
We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of rewarding food in a free choice (chow/rewarding food) paradigm. Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice. Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow. In comparison with sham rats, VTA-lesioned rats had normal intracerebroventricular ghrelin-induced chow intake, although both intake of and time spent exploring rewarding food was decreased. Finally, the ability of rewarding food to condition a place preference was suppressed by the GHS-R1A antagonist in rats. Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.

Show MeSH