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Ghrelin increases intake of rewarding food in rodents.

Egecioglu E, Jerlhag E, Salomé N, Skibicka KP, Haage D, Bohlooly-Y M, Andersson D, Bjursell M, Perrissoud D, Engel JA, Dickson SL - Addict Biol (2010)

Bottom Line: Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice.Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow.Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology/Endocrinology, The Sahlgrenska Academy at the University of Gothenburg, SE-405 30 Gothenburg, Sweden. emil.egecioglu@medic.gu.se

ABSTRACT
We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of rewarding food in a free choice (chow/rewarding food) paradigm. Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice. Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow. In comparison with sham rats, VTA-lesioned rats had normal intracerebroventricular ghrelin-induced chow intake, although both intake of and time spent exploring rewarding food was decreased. Finally, the ability of rewarding food to condition a place preference was suppressed by the GHS-R1A antagonist in rats. Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.

Show MeSH
(a) Body weight gain; (b) chow consumption; and (c) peanut butter consumption in growth hormone secretagogue receptor 1A knockout (GHS-R1A KO) and wild-type mice offered a free choice between ad libitum chow and peanut butter. n = 8 (wild-type) and n = 5 (GHS-R1A KO), *P < 0.05, Student's t-test
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fig01: (a) Body weight gain; (b) chow consumption; and (c) peanut butter consumption in growth hormone secretagogue receptor 1A knockout (GHS-R1A KO) and wild-type mice offered a free choice between ad libitum chow and peanut butter. n = 8 (wild-type) and n = 5 (GHS-R1A KO), *P < 0.05, Student's t-test

Mentions: When offered a free choice diet (chow/peanut butter) for 7 days, GHS-R1A KO mice consumed 10% less peanut butter compared with wild-type littermate mice (P < 0.05, Fig. 1c); chow intake and body weight did not differ (Fig. 1a,b). In a similar free-choice paradigm (chow/Ensure® for 10 days), JMV2959-treated rats consumed 50% less Ensure® and gained considerably less body weight than vehicle-treated controls (both P < 0.01, Fig. 2a,c). Chow intake was unaffected by JMV2959 treatment (Fig. 2b). Total 7-day caloric intake (chow plus Ensure®) was decreased in JMV2959-treated rats compared with vehicle-treated rats (591 ± 28 kcal and 839 ± 20 kcal, respectively, P < 0.001, Student's t-test). Thus, vehicle-treated rats consumed 65 ± 3% of their total caloric intake from Ensure®; whereas, JMV2959-treated rats consumed considerably less of their total caloric intake (46 ± 4%) from Ensure® (P < 0.05, Fig. 2d). Food efficiency was lower in JMV2959-treated compared with vehicle-treated rats (veh: 0.045 ± 0.003 and JMV2959: 0.015 ± 0.008, P < 0.05, Student's t-test).


Ghrelin increases intake of rewarding food in rodents.

Egecioglu E, Jerlhag E, Salomé N, Skibicka KP, Haage D, Bohlooly-Y M, Andersson D, Bjursell M, Perrissoud D, Engel JA, Dickson SL - Addict Biol (2010)

(a) Body weight gain; (b) chow consumption; and (c) peanut butter consumption in growth hormone secretagogue receptor 1A knockout (GHS-R1A KO) and wild-type mice offered a free choice between ad libitum chow and peanut butter. n = 8 (wild-type) and n = 5 (GHS-R1A KO), *P < 0.05, Student's t-test
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2901520&req=5

fig01: (a) Body weight gain; (b) chow consumption; and (c) peanut butter consumption in growth hormone secretagogue receptor 1A knockout (GHS-R1A KO) and wild-type mice offered a free choice between ad libitum chow and peanut butter. n = 8 (wild-type) and n = 5 (GHS-R1A KO), *P < 0.05, Student's t-test
Mentions: When offered a free choice diet (chow/peanut butter) for 7 days, GHS-R1A KO mice consumed 10% less peanut butter compared with wild-type littermate mice (P < 0.05, Fig. 1c); chow intake and body weight did not differ (Fig. 1a,b). In a similar free-choice paradigm (chow/Ensure® for 10 days), JMV2959-treated rats consumed 50% less Ensure® and gained considerably less body weight than vehicle-treated controls (both P < 0.01, Fig. 2a,c). Chow intake was unaffected by JMV2959 treatment (Fig. 2b). Total 7-day caloric intake (chow plus Ensure®) was decreased in JMV2959-treated rats compared with vehicle-treated rats (591 ± 28 kcal and 839 ± 20 kcal, respectively, P < 0.001, Student's t-test). Thus, vehicle-treated rats consumed 65 ± 3% of their total caloric intake from Ensure®; whereas, JMV2959-treated rats consumed considerably less of their total caloric intake (46 ± 4%) from Ensure® (P < 0.05, Fig. 2d). Food efficiency was lower in JMV2959-treated compared with vehicle-treated rats (veh: 0.045 ± 0.003 and JMV2959: 0.015 ± 0.008, P < 0.05, Student's t-test).

Bottom Line: Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice.Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow.Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology/Endocrinology, The Sahlgrenska Academy at the University of Gothenburg, SE-405 30 Gothenburg, Sweden. emil.egecioglu@medic.gu.se

ABSTRACT
We investigated whether ghrelin action at the level of the ventral tegmental area (VTA), a key node in the mesolimbic reward system, is important for the rewarding and motivational aspects of the consumption of rewarding/palatable food. Mice with a disrupted gene encoding the ghrelin receptor (GHS-R1A) and rats treated peripherally with a GHS-R1A antagonist both show suppressed intake of rewarding food in a free choice (chow/rewarding food) paradigm. Moreover, accumbal dopamine release induced by rewarding food was absent in GHS-R1A knockout mice. Acute bilateral intra-VTA administration of ghrelin increased 1-hour consumption of rewarding food but not standard chow. In comparison with sham rats, VTA-lesioned rats had normal intracerebroventricular ghrelin-induced chow intake, although both intake of and time spent exploring rewarding food was decreased. Finally, the ability of rewarding food to condition a place preference was suppressed by the GHS-R1A antagonist in rats. Our data support the hypothesis that central ghrelin signaling at the level of the VTA is important for the incentive value of rewarding food.

Show MeSH