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Patient-reported-outcomes in subjects with painful lumbar or cervical radiculopathy treated with pregabalin: evidence from medical practice in primary care settings.

Saldaña MT, Navarro A, Pérez C, Masramón X, Rejas J - Rheumatol. Int. (2009)

Bottom Line: A total of 490 (34%) patients were prescribed PGB-monotherapy, 702 (48%) received PGB add-on, and 159 (11%) were administered non-PGB drugs.After 12 weeks, significant improvements in pain, associated symptoms of anxiety, depression and sleep disturbances, general health; and level of disability were observed in the three groups, being significantly greater in PGB groups.In routine medical practice, monotherapy or add-on pregabalin is associated with substantial pain alleviation and associated symptoms improvements in painful cervical or lumbosacral radiculopathy.

View Article: PubMed Central - PubMed

Affiliation: Centro de Salud de Raíces, Av. del Campón 67, 33400, Castrillón (Asturias), Spain. zatosaldana@yahoo.es

ABSTRACT
The objective of this study was to evaluate the effect of pregabalin in painful cervical or lumbosacral radiculopathy treated in Primary Care settings under routine clinical practice. An observational, prospective 12-week secondary analysis was carried-out. Male and female above 18 years, naïve to PGB, with refractory chronic pain secondary to cervical/lumbosacral radiculopathy were enrolled. SF-MPQ, Sheehan Disability Inventory, MOS Sleep Scale, Hospital Anxiety and Depression Scale and the EQ-5D were administered. A total of 490 (34%) patients were prescribed PGB-monotherapy, 702 (48%) received PGB add-on, and 159 (11%) were administered non-PGB drugs. After 12 weeks, significant improvements in pain, associated symptoms of anxiety, depression and sleep disturbances, general health; and level of disability were observed in the three groups, being significantly greater in PGB groups. In routine medical practice, monotherapy or add-on pregabalin is associated with substantial pain alleviation and associated symptoms improvements in painful cervical or lumbosacral radiculopathy.

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Related in: MedlinePlus

Mean weekly change in health status as scored by the VAS of the EQ-5D
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Fig3: Mean weekly change in health status as scored by the VAS of the EQ-5D

Mentions: All treatment groups showed relevant improvement in the impact of painful radiculopathy on patient perceived stress and social and working activities as measured by the SDI (Table 4). Once again, these changes were significantly greater in the two groups that received PGB. General patient health according to the EQ-5D VAS also improved significantly more in the PGB-treated groups, and the clinical impact was likewise greater as measured by the effect size (Table 4), in turn giving rise to a greater gain in QALYs in the groups exposed to PGB (Table 4). These differences were seen to be significant from week 5 of the study, and maintained until week 12 (Fig. 3). In general terms, the benefit observed in each of the five dimensions of the EQ-5D was significantly greater in the groups treated with PGB, particularly among those patients that received the drug as monotherapy (Table 4).Fig. 3


Patient-reported-outcomes in subjects with painful lumbar or cervical radiculopathy treated with pregabalin: evidence from medical practice in primary care settings.

Saldaña MT, Navarro A, Pérez C, Masramón X, Rejas J - Rheumatol. Int. (2009)

Mean weekly change in health status as scored by the VAS of the EQ-5D
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2877314&req=5

Fig3: Mean weekly change in health status as scored by the VAS of the EQ-5D
Mentions: All treatment groups showed relevant improvement in the impact of painful radiculopathy on patient perceived stress and social and working activities as measured by the SDI (Table 4). Once again, these changes were significantly greater in the two groups that received PGB. General patient health according to the EQ-5D VAS also improved significantly more in the PGB-treated groups, and the clinical impact was likewise greater as measured by the effect size (Table 4), in turn giving rise to a greater gain in QALYs in the groups exposed to PGB (Table 4). These differences were seen to be significant from week 5 of the study, and maintained until week 12 (Fig. 3). In general terms, the benefit observed in each of the five dimensions of the EQ-5D was significantly greater in the groups treated with PGB, particularly among those patients that received the drug as monotherapy (Table 4).Fig. 3

Bottom Line: A total of 490 (34%) patients were prescribed PGB-monotherapy, 702 (48%) received PGB add-on, and 159 (11%) were administered non-PGB drugs.After 12 weeks, significant improvements in pain, associated symptoms of anxiety, depression and sleep disturbances, general health; and level of disability were observed in the three groups, being significantly greater in PGB groups.In routine medical practice, monotherapy or add-on pregabalin is associated with substantial pain alleviation and associated symptoms improvements in painful cervical or lumbosacral radiculopathy.

View Article: PubMed Central - PubMed

Affiliation: Centro de Salud de Raíces, Av. del Campón 67, 33400, Castrillón (Asturias), Spain. zatosaldana@yahoo.es

ABSTRACT
The objective of this study was to evaluate the effect of pregabalin in painful cervical or lumbosacral radiculopathy treated in Primary Care settings under routine clinical practice. An observational, prospective 12-week secondary analysis was carried-out. Male and female above 18 years, naïve to PGB, with refractory chronic pain secondary to cervical/lumbosacral radiculopathy were enrolled. SF-MPQ, Sheehan Disability Inventory, MOS Sleep Scale, Hospital Anxiety and Depression Scale and the EQ-5D were administered. A total of 490 (34%) patients were prescribed PGB-monotherapy, 702 (48%) received PGB add-on, and 159 (11%) were administered non-PGB drugs. After 12 weeks, significant improvements in pain, associated symptoms of anxiety, depression and sleep disturbances, general health; and level of disability were observed in the three groups, being significantly greater in PGB groups. In routine medical practice, monotherapy or add-on pregabalin is associated with substantial pain alleviation and associated symptoms improvements in painful cervical or lumbosacral radiculopathy.

Show MeSH
Related in: MedlinePlus