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Recovery index, attentiveness and state of memory after xenon or isoflurane anaesthesia: a randomized controlled trial.

Stuttmann R, Jakubetz J, Schultz K, Schäfer C, Langer S, Ullmann U, Hilbert P - BMC Anesthesiol (2010)

Bottom Line: The sum score of the SST delivered a clear trend one hour post extubation and a statistically significant superiority for Xenon three hours post extubation (p < 0.01).The RI likewise revealed a statistically significant superiority of Xenon 5 minutes post extubation (p < 0.01).The Aldrete score was significantly higher for 45 min.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Anaesthesiology/Intensive Care and Emergency Medicine/Pain Therapy, BG-Kliniken Bergmannstrost, (Merseburger Strasse 165), Halle/Saale, (06112), Germany. ralph.stuttmann@bergmannstrost.com.

ABSTRACT

Background: Performance of patients immediately after anaesthesia is an area of special interest and so a clinical trial was conducted to compare Xenon with Isoflurane anaesthesia. In order to assess the early cognitive recovery the syndrome short test (SST) according to Erzigkeit (Geromed GmbH) was applied.

Methods: ASA I and II patients undergoing long and short surgical interventions were randomised to receive either general anaesthesia with Xenon or Isoflurane. The primary endpoint was the validated SST which covering memory disturbances and attentiveness. The test was used on the day prior to intervention, one and three hours post extubation. The secondary endpoint was the recovery index (RI) measured after the end of the inhalation of Xenon or Isoflurane. In addition the Aldrete score was evaluated up to 180 min. On the first post-operative day the patients rated the quality of the anaesthetic using a scoring system from 1-6.

Results: The demographics of the groups were similar. The sum score of the SST delivered a clear trend one hour post extubation and a statistically significant superiority for Xenon three hours post extubation (p < 0.01). The RI likewise revealed a statistically significant superiority of Xenon 5 minutes post extubation (p < 0.01). The Aldrete score was significantly higher for 45 min. The scoring system results were also better after Xenon anaesthesia (p < 0.001).

Conclusions: The results show that recovery from anaesthesia and the early return of post-operative cognitive functions are significantly better after Xenon anaesthesia compared to Isoflurane. The results of the RI for Xenon are similar with the previously published results.

Trial registration: The trial was registered with the number ISRCTN01110844 http://www.controlled-trials.com/isrctn/pf/01110844.

No MeSH data available.


Related in: MedlinePlus

Mean Recovery Index.
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Figure 1: Mean Recovery Index.

Mentions: In accordance with the previous findings the results of the post-operative RI demonstrated a clear superiority of Xenon in comparison with Isoflurane (Xenon: RI 1.0 SD 0.6; CI95: 0.8-1.2; Isoflurane: RI 0.3 SD 0.1; CI95: 0.2-0.4) which was confirmed by a statistical significant and clinically relevant difference (P < 0.01). These results are visualized in Figure 1 and all the data used to calculate the RI is in Table 3.


Recovery index, attentiveness and state of memory after xenon or isoflurane anaesthesia: a randomized controlled trial.

Stuttmann R, Jakubetz J, Schultz K, Schäfer C, Langer S, Ullmann U, Hilbert P - BMC Anesthesiol (2010)

Mean Recovery Index.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2877044&req=5

Figure 1: Mean Recovery Index.
Mentions: In accordance with the previous findings the results of the post-operative RI demonstrated a clear superiority of Xenon in comparison with Isoflurane (Xenon: RI 1.0 SD 0.6; CI95: 0.8-1.2; Isoflurane: RI 0.3 SD 0.1; CI95: 0.2-0.4) which was confirmed by a statistical significant and clinically relevant difference (P < 0.01). These results are visualized in Figure 1 and all the data used to calculate the RI is in Table 3.

Bottom Line: The sum score of the SST delivered a clear trend one hour post extubation and a statistically significant superiority for Xenon three hours post extubation (p < 0.01).The RI likewise revealed a statistically significant superiority of Xenon 5 minutes post extubation (p < 0.01).The Aldrete score was significantly higher for 45 min.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Anaesthesiology/Intensive Care and Emergency Medicine/Pain Therapy, BG-Kliniken Bergmannstrost, (Merseburger Strasse 165), Halle/Saale, (06112), Germany. ralph.stuttmann@bergmannstrost.com.

ABSTRACT

Background: Performance of patients immediately after anaesthesia is an area of special interest and so a clinical trial was conducted to compare Xenon with Isoflurane anaesthesia. In order to assess the early cognitive recovery the syndrome short test (SST) according to Erzigkeit (Geromed GmbH) was applied.

Methods: ASA I and II patients undergoing long and short surgical interventions were randomised to receive either general anaesthesia with Xenon or Isoflurane. The primary endpoint was the validated SST which covering memory disturbances and attentiveness. The test was used on the day prior to intervention, one and three hours post extubation. The secondary endpoint was the recovery index (RI) measured after the end of the inhalation of Xenon or Isoflurane. In addition the Aldrete score was evaluated up to 180 min. On the first post-operative day the patients rated the quality of the anaesthetic using a scoring system from 1-6.

Results: The demographics of the groups were similar. The sum score of the SST delivered a clear trend one hour post extubation and a statistically significant superiority for Xenon three hours post extubation (p < 0.01). The RI likewise revealed a statistically significant superiority of Xenon 5 minutes post extubation (p < 0.01). The Aldrete score was significantly higher for 45 min. The scoring system results were also better after Xenon anaesthesia (p < 0.001).

Conclusions: The results show that recovery from anaesthesia and the early return of post-operative cognitive functions are significantly better after Xenon anaesthesia compared to Isoflurane. The results of the RI for Xenon are similar with the previously published results.

Trial registration: The trial was registered with the number ISRCTN01110844 http://www.controlled-trials.com/isrctn/pf/01110844.

No MeSH data available.


Related in: MedlinePlus