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Clinical significance of EGFR, Her-2 and EGF in oral squamous cell carcinoma: a case control study.

Bernardes VF, Gleber-Netto FO, Sousa SF, Silva TA, Aguiar MC - J. Exp. Clin. Cancer Res. (2010)

Bottom Line: The erbB receptors and their ligands are involved in the pathogenesis and progression of oral squamous cell carcinoma (OSCC).No association was detectable among receptor salivary levels, tissue expression and clinicopathological features.EGF levels in pre-surgery group were significantly lower when compared to the control group.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

ABSTRACT

Background: The erbB receptors and their ligands are involved in the pathogenesis and progression of oral squamous cell carcinoma (OSCC). Although EGFR and Her-2 are frequently overexpressed in OSCC, few studies evaluated these proteins in saliva and their association with the tumor, which may represent potential usefulness in a clinical setting.

Methods: The levels of EGFR, Her-2, and EGF were evaluated in saliva of 46 patients with OSCC before and after the surgical removal of the lesion, as well as in matched healthy controls. The relationship of salivary levels and EGFR and Her-2 immunoexpression in tumor samples with clinicopathological features was analyzed.

Results: EGFR and Her-2 salivary levels did not show difference between to pre-surgery and control groups, however, both demonstrated an increase after surgical removal of the tumor. No association was detectable among receptor salivary levels, tissue expression and clinicopathological features. EGF levels in pre-surgery group were significantly lower when compared to the control group.

Conclusions: EGFR and Her-2 were not considered to be valuable salivary tumor markers in OSCC, however, lower levels of EGF in saliva may suggest a higher susceptibility for OSCC development.

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Related in: MedlinePlus

Immunoexpression of EGFR and Her-2. a: positive immunoexpression of EGFR in OSCC (400×); b: negative expression of Her-2 in OSCC (400×).
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Figure 1: Immunoexpression of EGFR and Her-2. a: positive immunoexpression of EGFR in OSCC (400×); b: negative expression of Her-2 in OSCC (400×).

Mentions: Fourteen tumors were graded as well differentiated (30.4%), 14 moderately differentiated (30.4%), and 18 poorly differentiated (39.2%). The EGFR immunohistochemical expression was considered positive in 23 (50%) cases (Figure 1a), while 23 tumors (50%) proved to be negative (Table 1). The well differentiated tumors were more frequently positive for EGFR than were the others (p < 0.05) The Her-2 protein expression was found to be negative in 45 (97.8%) cases (Table 1) (Figure 1b).


Clinical significance of EGFR, Her-2 and EGF in oral squamous cell carcinoma: a case control study.

Bernardes VF, Gleber-Netto FO, Sousa SF, Silva TA, Aguiar MC - J. Exp. Clin. Cancer Res. (2010)

Immunoexpression of EGFR and Her-2. a: positive immunoexpression of EGFR in OSCC (400×); b: negative expression of Her-2 in OSCC (400×).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2877010&req=5

Figure 1: Immunoexpression of EGFR and Her-2. a: positive immunoexpression of EGFR in OSCC (400×); b: negative expression of Her-2 in OSCC (400×).
Mentions: Fourteen tumors were graded as well differentiated (30.4%), 14 moderately differentiated (30.4%), and 18 poorly differentiated (39.2%). The EGFR immunohistochemical expression was considered positive in 23 (50%) cases (Figure 1a), while 23 tumors (50%) proved to be negative (Table 1). The well differentiated tumors were more frequently positive for EGFR than were the others (p < 0.05) The Her-2 protein expression was found to be negative in 45 (97.8%) cases (Table 1) (Figure 1b).

Bottom Line: The erbB receptors and their ligands are involved in the pathogenesis and progression of oral squamous cell carcinoma (OSCC).No association was detectable among receptor salivary levels, tissue expression and clinicopathological features.EGF levels in pre-surgery group were significantly lower when compared to the control group.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

ABSTRACT

Background: The erbB receptors and their ligands are involved in the pathogenesis and progression of oral squamous cell carcinoma (OSCC). Although EGFR and Her-2 are frequently overexpressed in OSCC, few studies evaluated these proteins in saliva and their association with the tumor, which may represent potential usefulness in a clinical setting.

Methods: The levels of EGFR, Her-2, and EGF were evaluated in saliva of 46 patients with OSCC before and after the surgical removal of the lesion, as well as in matched healthy controls. The relationship of salivary levels and EGFR and Her-2 immunoexpression in tumor samples with clinicopathological features was analyzed.

Results: EGFR and Her-2 salivary levels did not show difference between to pre-surgery and control groups, however, both demonstrated an increase after surgical removal of the tumor. No association was detectable among receptor salivary levels, tissue expression and clinicopathological features. EGF levels in pre-surgery group were significantly lower when compared to the control group.

Conclusions: EGFR and Her-2 were not considered to be valuable salivary tumor markers in OSCC, however, lower levels of EGF in saliva may suggest a higher susceptibility for OSCC development.

Show MeSH
Related in: MedlinePlus