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Analgesic and anti-inflammatory activity of Argyreia speciosa root.

Bachhav RS, Gulecha VS, Upasani CD - Indian J Pharmacol (2009)

Bottom Line: The ME of A. speciosa root was used in pain and inflammation models.The ME of the A. speciosa at doses (30, 100, and 300mg/kg) showed significant (P < 0.01) inhibition of carrageenan induced hind paw edema in rats.The ME of A. speciosa showed significant analgesic and anti-inflammatory activity in mice and rat.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, S.N.J.B'S S.S.D.J. College of Pharmacy Chandwad, Dist. Nashik - 423 101, Maharashtra, India.

ABSTRACT

Objective: To study analgesic and anti-inflammatory activities of a methanolic extract (ME) of Argyreia speciosa (AS) root powder.

Materials and methods: The study was carried out using male albino mice (20-25 gm) and male wistar rats (100-150gm). The ME was prepared using soxhlet extraction process. The effect of ME of A. speciosa was investigated for analgesic activity using acetic acid-induced abdominal constriction, tail immersion method and hot plate method. The anti-inflammatory activity of ME of AS roots was studied using carrageenan-induced rat paw edema.

Result: The ME of A. speciosa root was used in pain and inflammation models. The analgesic activity of AS at the dose of (30,100, and 300 mg/kg p.o) showed significant (P<0.01) decrease in acetic acid-induced writhing, whereas ME of A. speciosa at the dose of (100, 300 mg/kg p.o) showed significant (P<0.01) increase in latency to tail flick in tail immersion method and elevated mean basal reaction time in hot plate method. The ME of the A. speciosa at doses (30, 100, and 300mg/kg) showed significant (P < 0.01) inhibition of carrageenan induced hind paw edema in rats.

Conclusion: The ME of A. speciosa showed significant analgesic and anti-inflammatory activity in mice and rat.

No MeSH data available.


Related in: MedlinePlus

Effect of ME of A. speciosa (30, 100, and 300 mg/kg) on mean reaction time by hot plate method in mice
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Figure 0003: Effect of ME of A. speciosa (30, 100, and 300 mg/kg) on mean reaction time by hot plate method in mice

Mentions: The ME of A. speciosa (30mg/kg, p.o.) did not show significant (P > 0.05) increase in the mean basal reaction time in hot plate method compared to control. The ME of A. speciosa at doses (100 and 300 mg/kg, p.o.) showed significant (P < 0.01) increase in the mean basal reaction time. The highest nociception inhibition of stimulus exhibited by ME of A. speciosa (300 mg/kg) was observed at 15 minutes [Figure 3].


Analgesic and anti-inflammatory activity of Argyreia speciosa root.

Bachhav RS, Gulecha VS, Upasani CD - Indian J Pharmacol (2009)

Effect of ME of A. speciosa (30, 100, and 300 mg/kg) on mean reaction time by hot plate method in mice
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2875733&req=5

Figure 0003: Effect of ME of A. speciosa (30, 100, and 300 mg/kg) on mean reaction time by hot plate method in mice
Mentions: The ME of A. speciosa (30mg/kg, p.o.) did not show significant (P > 0.05) increase in the mean basal reaction time in hot plate method compared to control. The ME of A. speciosa at doses (100 and 300 mg/kg, p.o.) showed significant (P < 0.01) increase in the mean basal reaction time. The highest nociception inhibition of stimulus exhibited by ME of A. speciosa (300 mg/kg) was observed at 15 minutes [Figure 3].

Bottom Line: The ME of A. speciosa root was used in pain and inflammation models.The ME of the A. speciosa at doses (30, 100, and 300mg/kg) showed significant (P < 0.01) inhibition of carrageenan induced hind paw edema in rats.The ME of A. speciosa showed significant analgesic and anti-inflammatory activity in mice and rat.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, S.N.J.B'S S.S.D.J. College of Pharmacy Chandwad, Dist. Nashik - 423 101, Maharashtra, India.

ABSTRACT

Objective: To study analgesic and anti-inflammatory activities of a methanolic extract (ME) of Argyreia speciosa (AS) root powder.

Materials and methods: The study was carried out using male albino mice (20-25 gm) and male wistar rats (100-150gm). The ME was prepared using soxhlet extraction process. The effect of ME of A. speciosa was investigated for analgesic activity using acetic acid-induced abdominal constriction, tail immersion method and hot plate method. The anti-inflammatory activity of ME of AS roots was studied using carrageenan-induced rat paw edema.

Result: The ME of A. speciosa root was used in pain and inflammation models. The analgesic activity of AS at the dose of (30,100, and 300 mg/kg p.o) showed significant (P<0.01) decrease in acetic acid-induced writhing, whereas ME of A. speciosa at the dose of (100, 300 mg/kg p.o) showed significant (P<0.01) increase in latency to tail flick in tail immersion method and elevated mean basal reaction time in hot plate method. The ME of the A. speciosa at doses (30, 100, and 300mg/kg) showed significant (P < 0.01) inhibition of carrageenan induced hind paw edema in rats.

Conclusion: The ME of A. speciosa showed significant analgesic and anti-inflammatory activity in mice and rat.

No MeSH data available.


Related in: MedlinePlus