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Differential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium.

Tran PA, Sarin L, Hurt RH, Webster TJ - Int J Nanomedicine (2010)

Bottom Line: Normal healthy osteoblasts (bone-forming cells) and cancerous osteoblasts (osteosarcoma) were cultured on the Se-doped surfaces having three different coating densities.For the first time, it is shown that substrates with Se nanoclusters promote normal osteoblast proliferation and inhibit cancerous osteoblast growth in both separate (mono-culture) and coculture experiment.This study suggests that Se surface nanoclusters can be properly engineered to inhibit bone cancer growth while simultaneously promoting the growth of normal bone tissue.

View Article: PubMed Central - PubMed

Affiliation: Physics Department, BrownUniversity, Providence, RI 02912, USA.

ABSTRACT
In the present study, selenium (Se) nanoclusters were grown through heterogeneous nucleation on titanium (Ti) surfaces, a common orthopedic implant material. Normal healthy osteoblasts (bone-forming cells) and cancerous osteoblasts (osteosarcoma) were cultured on the Se-doped surfaces having three different coating densities. For the first time, it is shown that substrates with Se nanoclusters promote normal osteoblast proliferation and inhibit cancerous osteoblast growth in both separate (mono-culture) and coculture experiment. This study suggests that Se surface nanoclusters can be properly engineered to inhibit bone cancer growth while simultaneously promoting the growth of normal bone tissue.

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Water contact angles on the uncoated and Se-coated Ti substrates. Contact angles increased on the substrates coated with selenium nanoclusters.Notes: Data = mean ± SEM; N = 3; *P < 0.05 compared to all the coated substrates. There was no significant difference among the contact angles on the coated substrates.Abbreviations: Se, selenium; SEM, standard error of mean; Ti, titanium.
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f2-ijn-5-351: Water contact angles on the uncoated and Se-coated Ti substrates. Contact angles increased on the substrates coated with selenium nanoclusters.Notes: Data = mean ± SEM; N = 3; *P < 0.05 compared to all the coated substrates. There was no significant difference among the contact angles on the coated substrates.Abbreviations: Se, selenium; SEM, standard error of mean; Ti, titanium.

Mentions: Uncoated Ti substrates were hydrophilic with an average water contact angle of approximately 55°. Importantly, coating Ti with selenium nanoclusters made the Ti surfaces more hydrophobic (Figure 2).


Differential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium.

Tran PA, Sarin L, Hurt RH, Webster TJ - Int J Nanomedicine (2010)

Water contact angles on the uncoated and Se-coated Ti substrates. Contact angles increased on the substrates coated with selenium nanoclusters.Notes: Data = mean ± SEM; N = 3; *P < 0.05 compared to all the coated substrates. There was no significant difference among the contact angles on the coated substrates.Abbreviations: Se, selenium; SEM, standard error of mean; Ti, titanium.
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2875729&req=5

f2-ijn-5-351: Water contact angles on the uncoated and Se-coated Ti substrates. Contact angles increased on the substrates coated with selenium nanoclusters.Notes: Data = mean ± SEM; N = 3; *P < 0.05 compared to all the coated substrates. There was no significant difference among the contact angles on the coated substrates.Abbreviations: Se, selenium; SEM, standard error of mean; Ti, titanium.
Mentions: Uncoated Ti substrates were hydrophilic with an average water contact angle of approximately 55°. Importantly, coating Ti with selenium nanoclusters made the Ti surfaces more hydrophobic (Figure 2).

Bottom Line: Normal healthy osteoblasts (bone-forming cells) and cancerous osteoblasts (osteosarcoma) were cultured on the Se-doped surfaces having three different coating densities.For the first time, it is shown that substrates with Se nanoclusters promote normal osteoblast proliferation and inhibit cancerous osteoblast growth in both separate (mono-culture) and coculture experiment.This study suggests that Se surface nanoclusters can be properly engineered to inhibit bone cancer growth while simultaneously promoting the growth of normal bone tissue.

View Article: PubMed Central - PubMed

Affiliation: Physics Department, BrownUniversity, Providence, RI 02912, USA.

ABSTRACT
In the present study, selenium (Se) nanoclusters were grown through heterogeneous nucleation on titanium (Ti) surfaces, a common orthopedic implant material. Normal healthy osteoblasts (bone-forming cells) and cancerous osteoblasts (osteosarcoma) were cultured on the Se-doped surfaces having three different coating densities. For the first time, it is shown that substrates with Se nanoclusters promote normal osteoblast proliferation and inhibit cancerous osteoblast growth in both separate (mono-culture) and coculture experiment. This study suggests that Se surface nanoclusters can be properly engineered to inhibit bone cancer growth while simultaneously promoting the growth of normal bone tissue.

Show MeSH
Related in: MedlinePlus