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Hypertension and hyperparathyroidism are associated with left ventricular hypertrophy in patients on hemodialysis.

Al-Hilali N, Hussain N, Ataia AI, Al-Azmi M, Al-Helal B, Johny KV - Indian J Nephrol (2009)

Bottom Line: Both high BP and high iPTH were present in 38 (29.2%) patients.Analysis of the relationship between LVM, LVMI, MAP and iPTH showed that LVM and LVMI were significantly (P < 0.001) higher in patients with concomitant high BP and high iPTH.LVMI was significantly higher in patients with high iPTH alone.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Mubarak Al-Kabeer Hospital, Kuwait.

ABSTRACT
Conflicting data for association between left ventricular hypertrophy (LVH) and secondary hyperparathyroidism has been reported previously among dialysis patients. The present study was conducted to evaluate the association of hyperparathyroidism and hypertension with LVH. Charts of 130 patients on hemodialysis for at least six months were reviewed. All were subjected to M-mode echocardiography. Left ventricular mass (LVM) was calculated by Devereux's formula. LVM Index (LVMI) was calculated by dividing LVM by body surface area. Sera were analyzed for intact parathyroid hormone (iPTH). iPTH of > 32 pmol/l and a mean blood pressure (MAP) of > 107 mmHg were considered high. Patients were stratified into groups according to their MAP and iPTH. A total of (47.7%) patients were males and 68 (52.3%) were females. Their median age was 57 years. The median duration on dialysis was 26 months. Forty eight (36.9%) patients had high BP and 54 (41.5%) had high iPTH. Both high BP and high iPTH were present in 38 (29.2%) patients. Analysis of the relationship between LVM, LVMI, MAP and iPTH showed that LVM and LVMI were significantly (P < 0.001) higher in patients with concomitant high BP and high iPTH. LVMI was significantly higher in patients with high iPTH alone. Concomitant high iPTH and high MAP increase the risk of LVH in hemodialysis patients. High iPTH alone might contribute in escalating LVH. Adequate control of hypertension and hyperparathyroidism might reduce the risk of developing LVH.

No MeSH data available.


Related in: MedlinePlus

Correlation between intact parathyroid hormone (pmol/l) and left ventricular mass index (g/m2) of all patients; iPTH - Intact parathyroid hormone (pmol/l); LVMI - Left ventricular mass index (g/m2)
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Figure 0001: Correlation between intact parathyroid hormone (pmol/l) and left ventricular mass index (g/m2) of all patients; iPTH - Intact parathyroid hormone (pmol/l); LVMI - Left ventricular mass index (g/m2)

Mentions: Correlation between iPTH levels and LVM index of all patients are shown in Figure 1. LVM index values correlated positively with iPTH (R Sq 5 0.415, P, 0.0001). Correlation between MAP and LVM index of all patients are shown in Figure 2. LVM index values correlated positively with iPTH (R Sq 5 0.0.206, P, 0.0001).


Hypertension and hyperparathyroidism are associated with left ventricular hypertrophy in patients on hemodialysis.

Al-Hilali N, Hussain N, Ataia AI, Al-Azmi M, Al-Helal B, Johny KV - Indian J Nephrol (2009)

Correlation between intact parathyroid hormone (pmol/l) and left ventricular mass index (g/m2) of all patients; iPTH - Intact parathyroid hormone (pmol/l); LVMI - Left ventricular mass index (g/m2)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2875705&req=5

Figure 0001: Correlation between intact parathyroid hormone (pmol/l) and left ventricular mass index (g/m2) of all patients; iPTH - Intact parathyroid hormone (pmol/l); LVMI - Left ventricular mass index (g/m2)
Mentions: Correlation between iPTH levels and LVM index of all patients are shown in Figure 1. LVM index values correlated positively with iPTH (R Sq 5 0.415, P, 0.0001). Correlation between MAP and LVM index of all patients are shown in Figure 2. LVM index values correlated positively with iPTH (R Sq 5 0.0.206, P, 0.0001).

Bottom Line: Both high BP and high iPTH were present in 38 (29.2%) patients.Analysis of the relationship between LVM, LVMI, MAP and iPTH showed that LVM and LVMI were significantly (P < 0.001) higher in patients with concomitant high BP and high iPTH.LVMI was significantly higher in patients with high iPTH alone.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Mubarak Al-Kabeer Hospital, Kuwait.

ABSTRACT
Conflicting data for association between left ventricular hypertrophy (LVH) and secondary hyperparathyroidism has been reported previously among dialysis patients. The present study was conducted to evaluate the association of hyperparathyroidism and hypertension with LVH. Charts of 130 patients on hemodialysis for at least six months were reviewed. All were subjected to M-mode echocardiography. Left ventricular mass (LVM) was calculated by Devereux's formula. LVM Index (LVMI) was calculated by dividing LVM by body surface area. Sera were analyzed for intact parathyroid hormone (iPTH). iPTH of > 32 pmol/l and a mean blood pressure (MAP) of > 107 mmHg were considered high. Patients were stratified into groups according to their MAP and iPTH. A total of (47.7%) patients were males and 68 (52.3%) were females. Their median age was 57 years. The median duration on dialysis was 26 months. Forty eight (36.9%) patients had high BP and 54 (41.5%) had high iPTH. Both high BP and high iPTH were present in 38 (29.2%) patients. Analysis of the relationship between LVM, LVMI, MAP and iPTH showed that LVM and LVMI were significantly (P < 0.001) higher in patients with concomitant high BP and high iPTH. LVMI was significantly higher in patients with high iPTH alone. Concomitant high iPTH and high MAP increase the risk of LVH in hemodialysis patients. High iPTH alone might contribute in escalating LVH. Adequate control of hypertension and hyperparathyroidism might reduce the risk of developing LVH.

No MeSH data available.


Related in: MedlinePlus