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Immune response of cytotoxic T lymphocytes and possibility of vaccine development for hepatitis C virus infection.

Hiroishi K, Eguchi J, Ishii S, Hiraide A, Sakaki M, Doi H, Omori R, Imawari M - J. Biomed. Biotechnol. (2010)

Bottom Line: Thus, the development of a vaccine that can induce potent CTL response against HCV is strongly expected.Our findings may contribute to the development of the HCV vaccine.In this paper, we describe the CTL responses in HCV infection and the attempts at vaccine development based on recent scientific articles.

View Article: PubMed Central - PubMed

Affiliation: Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan.

ABSTRACT
Immune responses of cytotoxic T lymphocytes (CTLs) are implicated in viral eradication and the pathogenesis of hepatitis C. Weak CTL response against hepatitis C virus (HCV) may lead to a persistent infection. HCV infection impairs the function of HCV-specific CTLs; HCV proteins are thought to actively suppress host immune responses, including CTLs. Induction of a strong HCV-specific CTL response in HCV-infected patients can facilitate complete HCV clearance. Thus, the development of a vaccine that can induce potent CTL response against HCV is strongly expected. We investigated HCV-specific CTL responses by enzyme-linked immuno-spot assay and/or synthetic peptides and identified over 40 novel CTL epitopes in the HCV protein. Our findings may contribute to the development of the HCV vaccine. In this paper, we describe the CTL responses in HCV infection and the attempts at vaccine development based on recent scientific articles.

No MeSH data available.


Related in: MedlinePlus

Immune suppressive mechanisms in HCV infection. HCV mutates its amino acid sequence to escape from immune surveillance, inhibits type 1 IFN production, and suppress NK cell function, T-cell function, and DC function. In addition, HCV induces Tr cells, which suppress T-cell function. Abbreviated terms: CTL, Cytotoxic T lymphocyte; pDC, plasmacytoid dendritic cells; mDC, myeloid dendritic cells; Th cell, helper T cell; NK cell, natural killer cell; IFN, interferon.
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fig3: Immune suppressive mechanisms in HCV infection. HCV mutates its amino acid sequence to escape from immune surveillance, inhibits type 1 IFN production, and suppress NK cell function, T-cell function, and DC function. In addition, HCV induces Tr cells, which suppress T-cell function. Abbreviated terms: CTL, Cytotoxic T lymphocyte; pDC, plasmacytoid dendritic cells; mDC, myeloid dendritic cells; Th cell, helper T cell; NK cell, natural killer cell; IFN, interferon.

Mentions: HCV inhibits cellular immune responses in the host by several ways; immune suppressive mechanisms in HCV infection are summarized in Figure 3.


Immune response of cytotoxic T lymphocytes and possibility of vaccine development for hepatitis C virus infection.

Hiroishi K, Eguchi J, Ishii S, Hiraide A, Sakaki M, Doi H, Omori R, Imawari M - J. Biomed. Biotechnol. (2010)

Immune suppressive mechanisms in HCV infection. HCV mutates its amino acid sequence to escape from immune surveillance, inhibits type 1 IFN production, and suppress NK cell function, T-cell function, and DC function. In addition, HCV induces Tr cells, which suppress T-cell function. Abbreviated terms: CTL, Cytotoxic T lymphocyte; pDC, plasmacytoid dendritic cells; mDC, myeloid dendritic cells; Th cell, helper T cell; NK cell, natural killer cell; IFN, interferon.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2874944&req=5

fig3: Immune suppressive mechanisms in HCV infection. HCV mutates its amino acid sequence to escape from immune surveillance, inhibits type 1 IFN production, and suppress NK cell function, T-cell function, and DC function. In addition, HCV induces Tr cells, which suppress T-cell function. Abbreviated terms: CTL, Cytotoxic T lymphocyte; pDC, plasmacytoid dendritic cells; mDC, myeloid dendritic cells; Th cell, helper T cell; NK cell, natural killer cell; IFN, interferon.
Mentions: HCV inhibits cellular immune responses in the host by several ways; immune suppressive mechanisms in HCV infection are summarized in Figure 3.

Bottom Line: Thus, the development of a vaccine that can induce potent CTL response against HCV is strongly expected.Our findings may contribute to the development of the HCV vaccine.In this paper, we describe the CTL responses in HCV infection and the attempts at vaccine development based on recent scientific articles.

View Article: PubMed Central - PubMed

Affiliation: Division of Gastroenterology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan.

ABSTRACT
Immune responses of cytotoxic T lymphocytes (CTLs) are implicated in viral eradication and the pathogenesis of hepatitis C. Weak CTL response against hepatitis C virus (HCV) may lead to a persistent infection. HCV infection impairs the function of HCV-specific CTLs; HCV proteins are thought to actively suppress host immune responses, including CTLs. Induction of a strong HCV-specific CTL response in HCV-infected patients can facilitate complete HCV clearance. Thus, the development of a vaccine that can induce potent CTL response against HCV is strongly expected. We investigated HCV-specific CTL responses by enzyme-linked immuno-spot assay and/or synthetic peptides and identified over 40 novel CTL epitopes in the HCV protein. Our findings may contribute to the development of the HCV vaccine. In this paper, we describe the CTL responses in HCV infection and the attempts at vaccine development based on recent scientific articles.

No MeSH data available.


Related in: MedlinePlus