Effect of transglutaminase 2 (TG2) deficiency on atherosclerotic plaque stability in the apolipoprotein E deficient mouse.
Bottom Line: Transglutaminase 2 (TG2), a cross-linking enzyme that confers supra-molecular structures with extra rigidity and resistance against proteolytic degradation, is expressed in the shoulder regions of human atherosclerotic plaques.It has been proposed that TG2 prevents tearing and promotes plaque repair at these potential weak points, and also promotes ectopic calcification of arteries.The frequency of buried fibrous caps within brachiocephalic plaques was significantly higher in male than in female mice, but TG2 deficiency had no effect on either gender.
Affiliation: Bristol Heart Institute, University of Bristol, Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK.Show MeSH
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Mentions: The frequency of buried caps per mouse was significantly greater in males than females (2.21 ± 0.18 vs. 1.66 ± 0.17 respectively, p = 0.021), but there was no effect of TG2 deficiency in either sex. Up to six buried caps were detected in individual double-knockout mice (Fig. 2A). Rare instances of current unhealed ruptures were also observed (Fig. 2B) and occurred at similar frequencies in both groups (apoE/TG2 double-knockouts: 1 observed in 66 mice; apoE single knockouts: 2 observed in 51 mice).
Affiliation: Bristol Heart Institute, University of Bristol, Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK.