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Effect of transglutaminase 2 (TG2) deficiency on atherosclerotic plaque stability in the apolipoprotein E deficient mouse.

Williams H, Pease RJ, Newell LM, Cordell PA, Graham RM, Kearney MT, Jackson CL, Grant PJ - Atherosclerosis (2009)

Bottom Line: Transglutaminase 2 (TG2), a cross-linking enzyme that confers supra-molecular structures with extra rigidity and resistance against proteolytic degradation, is expressed in the shoulder regions of human atherosclerotic plaques.It has been proposed that TG2 prevents tearing and promotes plaque repair at these potential weak points, and also promotes ectopic calcification of arteries.The frequency of buried fibrous caps within brachiocephalic plaques was significantly higher in male than in female mice, but TG2 deficiency had no effect on either gender.

View Article: PubMed Central - PubMed

Affiliation: Bristol Heart Institute, University of Bristol, Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK.

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Related in: MedlinePlus

Sections of mouse brachiocephalic plaques stained for elastin. Scale bars represent 200 μm in Panel A and 100 μm in Panel B. Panel (A): Multiple buried caps (arrowheads) present in a plaque from an apoE/TG2 double-knockout mouse. Panel (B): A current rupture in a plaque from an apoE/TG2 double-knockout mouse (arrowhead). Red blood cells have permeated the plaque at the point of rupture.
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fig2: Sections of mouse brachiocephalic plaques stained for elastin. Scale bars represent 200 μm in Panel A and 100 μm in Panel B. Panel (A): Multiple buried caps (arrowheads) present in a plaque from an apoE/TG2 double-knockout mouse. Panel (B): A current rupture in a plaque from an apoE/TG2 double-knockout mouse (arrowhead). Red blood cells have permeated the plaque at the point of rupture.

Mentions: The frequency of buried caps per mouse was significantly greater in males than females (2.21 ± 0.18 vs. 1.66 ± 0.17 respectively, p = 0.021), but there was no effect of TG2 deficiency in either sex. Up to six buried caps were detected in individual double-knockout mice (Fig. 2A). Rare instances of current unhealed ruptures were also observed (Fig. 2B) and occurred at similar frequencies in both groups (apoE/TG2 double-knockouts: 1 observed in 66 mice; apoE single knockouts: 2 observed in 51 mice).


Effect of transglutaminase 2 (TG2) deficiency on atherosclerotic plaque stability in the apolipoprotein E deficient mouse.

Williams H, Pease RJ, Newell LM, Cordell PA, Graham RM, Kearney MT, Jackson CL, Grant PJ - Atherosclerosis (2009)

Sections of mouse brachiocephalic plaques stained for elastin. Scale bars represent 200 μm in Panel A and 100 μm in Panel B. Panel (A): Multiple buried caps (arrowheads) present in a plaque from an apoE/TG2 double-knockout mouse. Panel (B): A current rupture in a plaque from an apoE/TG2 double-knockout mouse (arrowhead). Red blood cells have permeated the plaque at the point of rupture.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2874840&req=5

fig2: Sections of mouse brachiocephalic plaques stained for elastin. Scale bars represent 200 μm in Panel A and 100 μm in Panel B. Panel (A): Multiple buried caps (arrowheads) present in a plaque from an apoE/TG2 double-knockout mouse. Panel (B): A current rupture in a plaque from an apoE/TG2 double-knockout mouse (arrowhead). Red blood cells have permeated the plaque at the point of rupture.
Mentions: The frequency of buried caps per mouse was significantly greater in males than females (2.21 ± 0.18 vs. 1.66 ± 0.17 respectively, p = 0.021), but there was no effect of TG2 deficiency in either sex. Up to six buried caps were detected in individual double-knockout mice (Fig. 2A). Rare instances of current unhealed ruptures were also observed (Fig. 2B) and occurred at similar frequencies in both groups (apoE/TG2 double-knockouts: 1 observed in 66 mice; apoE single knockouts: 2 observed in 51 mice).

Bottom Line: Transglutaminase 2 (TG2), a cross-linking enzyme that confers supra-molecular structures with extra rigidity and resistance against proteolytic degradation, is expressed in the shoulder regions of human atherosclerotic plaques.It has been proposed that TG2 prevents tearing and promotes plaque repair at these potential weak points, and also promotes ectopic calcification of arteries.The frequency of buried fibrous caps within brachiocephalic plaques was significantly higher in male than in female mice, but TG2 deficiency had no effect on either gender.

View Article: PubMed Central - PubMed

Affiliation: Bristol Heart Institute, University of Bristol, Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK.

Show MeSH
Related in: MedlinePlus