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Early incidence of occupational asthma among young bakers, pastry-makers and hairdressers: design of a retrospective cohort study.

Rémen T, Coevoet V, Acouetey DS, Guéant JL, Guéant-Rodriguez RM, Paris C, Zmirou-Navier D - BMC Public Health (2010)

Bottom Line: Occupational exposures are thought to be responsible for 10-15% of new-onset asthma cases in adults, with disparities across sectors.A phone interview focusing on respiratory and 'Ear-Nose-Throat' (ENT) work-related symptoms screen subjects considered as "possibly OA cases".Such a time frame would be suited for conducting screening campaigns of this emergent asthma at a stage when occupational hygiene measures and adapted therapeutic interventions might be effective.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institut National de la santé et de la Recherche Médicale U 954, School of Medicine, Nancy, France. thomas.remen@nancy.inserm.fr

ABSTRACT

Background: Occupational exposures are thought to be responsible for 10-15% of new-onset asthma cases in adults, with disparities across sectors. Because most of the data are derived from registries and cross-sectional studies, little is known about incidence of occupational asthma (OA) during the first years after inception of exposure. This paper describes the design of a study that focuses on this early asthma onset period among young workers in the bakery, pastry making and hairdressing sectors in order to assess early incidence of OA in these "at risk" occupations according to exposure duration, and to identify risk factors of OA incidence.

Methods/design: The study population is composed of subjects who graduated between 2001 and 2006 in these sectors where they experience exposure to organic or inorganic allergenic or irritant compounds (with an objective of 150 subjects by year) and 250 young workers with no specific occupational exposure. A phone interview focusing on respiratory and 'Ear-Nose-Throat' (ENT) work-related symptoms screen subjects considered as "possibly OA cases". Subjects are invited to participate in a medical visit to complete clinical and lung function investigations, including fractional exhaled nitric oxide (FENO) and carbon monoxide (CO) measurements, and to collect blood samples for IgE (Immunoglobulin E) measurements (total IgE and IgE for work-related and common allergens). Markers of oxidative stress and genetic polymorphisms exploration are also assessed. A random sample of 200 "non-cases" (controls) is also visited, following a nested case-control design.

Discussion: This study may allow to describ a latent period between inception of exposure and the rise of the prevalence of asthma symptoms, an information that would be useful for the prevention of OA. Such a time frame would be suited for conducting screening campaigns of this emergent asthma at a stage when occupational hygiene measures and adapted therapeutic interventions might be effective.

Trial registration: Clinical trial registration number is NCT01096537.

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Related in: MedlinePlus

Decision tree for the definition of occupational asthma. * Variability is defined by the Oasys-2 score as deterioration during a work period or improvement during a period away from work of at least 20%. ** When only ENT symptoms are present, the diagnosis of infraclinic OA is more appropriate. *** IgE Assay (bakers and pastry makers) and prick-tests (hairdressers) were realized for specific occupational allergens.
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Figure 1: Decision tree for the definition of occupational asthma. * Variability is defined by the Oasys-2 score as deterioration during a work period or improvement during a period away from work of at least 20%. ** When only ENT symptoms are present, the diagnosis of infraclinic OA is more appropriate. *** IgE Assay (bakers and pastry makers) and prick-tests (hairdressers) were realized for specific occupational allergens.

Mentions: The OA diagnosis is made in two times: (i) diagnosing asthma, and (ii) highlighting a temporal relation of symptoms with work activities. The decision tree for defining OA is presented in figure 1. The tests that are undertaken during the medical visit at home to confirm a case of OA will be presented further.


Early incidence of occupational asthma among young bakers, pastry-makers and hairdressers: design of a retrospective cohort study.

Rémen T, Coevoet V, Acouetey DS, Guéant JL, Guéant-Rodriguez RM, Paris C, Zmirou-Navier D - BMC Public Health (2010)

Decision tree for the definition of occupational asthma. * Variability is defined by the Oasys-2 score as deterioration during a work period or improvement during a period away from work of at least 20%. ** When only ENT symptoms are present, the diagnosis of infraclinic OA is more appropriate. *** IgE Assay (bakers and pastry makers) and prick-tests (hairdressers) were realized for specific occupational allergens.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2874777&req=5

Figure 1: Decision tree for the definition of occupational asthma. * Variability is defined by the Oasys-2 score as deterioration during a work period or improvement during a period away from work of at least 20%. ** When only ENT symptoms are present, the diagnosis of infraclinic OA is more appropriate. *** IgE Assay (bakers and pastry makers) and prick-tests (hairdressers) were realized for specific occupational allergens.
Mentions: The OA diagnosis is made in two times: (i) diagnosing asthma, and (ii) highlighting a temporal relation of symptoms with work activities. The decision tree for defining OA is presented in figure 1. The tests that are undertaken during the medical visit at home to confirm a case of OA will be presented further.

Bottom Line: Occupational exposures are thought to be responsible for 10-15% of new-onset asthma cases in adults, with disparities across sectors.A phone interview focusing on respiratory and 'Ear-Nose-Throat' (ENT) work-related symptoms screen subjects considered as "possibly OA cases".Such a time frame would be suited for conducting screening campaigns of this emergent asthma at a stage when occupational hygiene measures and adapted therapeutic interventions might be effective.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institut National de la santé et de la Recherche Médicale U 954, School of Medicine, Nancy, France. thomas.remen@nancy.inserm.fr

ABSTRACT

Background: Occupational exposures are thought to be responsible for 10-15% of new-onset asthma cases in adults, with disparities across sectors. Because most of the data are derived from registries and cross-sectional studies, little is known about incidence of occupational asthma (OA) during the first years after inception of exposure. This paper describes the design of a study that focuses on this early asthma onset period among young workers in the bakery, pastry making and hairdressing sectors in order to assess early incidence of OA in these "at risk" occupations according to exposure duration, and to identify risk factors of OA incidence.

Methods/design: The study population is composed of subjects who graduated between 2001 and 2006 in these sectors where they experience exposure to organic or inorganic allergenic or irritant compounds (with an objective of 150 subjects by year) and 250 young workers with no specific occupational exposure. A phone interview focusing on respiratory and 'Ear-Nose-Throat' (ENT) work-related symptoms screen subjects considered as "possibly OA cases". Subjects are invited to participate in a medical visit to complete clinical and lung function investigations, including fractional exhaled nitric oxide (FENO) and carbon monoxide (CO) measurements, and to collect blood samples for IgE (Immunoglobulin E) measurements (total IgE and IgE for work-related and common allergens). Markers of oxidative stress and genetic polymorphisms exploration are also assessed. A random sample of 200 "non-cases" (controls) is also visited, following a nested case-control design.

Discussion: This study may allow to describ a latent period between inception of exposure and the rise of the prevalence of asthma symptoms, an information that would be useful for the prevention of OA. Such a time frame would be suited for conducting screening campaigns of this emergent asthma at a stage when occupational hygiene measures and adapted therapeutic interventions might be effective.

Trial registration: Clinical trial registration number is NCT01096537.

Show MeSH
Related in: MedlinePlus