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Plasma adipokine and inflammatory marker concentrations are altered in obese, as opposed to non-obese, type 2 diabetes patients.

Hansen D, Dendale P, Beelen M, Jonkers RA, Mullens A, Corluy L, Meeusen R, van Loon LJ - Eur. J. Appl. Physiol. (2010)

Bottom Line: Plasma FFA, inflammatory marker (hsCRP, IL-6, TNFalpha), adipokine (adiponectin, resistin, leptin), and triglyceride concentrations did not differ between non-obese diabetes patients and healthy, normoglycemic controls.Plasma FFA, IL-6, hsCRP, leptin, and triglyceride levels were significantly higher in the obese diabetes patients when compared with the healthy normoglycemic controls (P < 0.05).Furthermore, plasma hsCRP and leptin levels were significantly higher in the obese versus non-obese diabetes patients (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Human Physiology and Sportsmedicine, Vrije Universiteit Brussel (VUB), Brussels, Belgium. Hansen_dominique@yahoo.com

ABSTRACT
Elevated plasma free fatty acid (FFA), inflammatory marker, and altered adipokine concentrations have been observed in obese type 2 diabetes patients. It remains unclear whether these altered plasma concentrations are related to the diabetic state or presence of obesity. In this cross-sectional observational study, we compare basal plasma FFA, inflammatory marker, and adipokine concentrations between obese and non-obese type 2 diabetes patients and healthy, non-obese controls. A total of 20 healthy, normoglycemic males (BMI <30 kg/m(2)), 20 non-obese (BMI <30 kg/m(2)) and 20 obese (BMI >35 kg/m(2)) type 2 diabetes patients were selected to participate in this study. Groups were matched for age and habitual physical activity level. Body composition, glycemic control, and exercise performance capacity were assessed. Basal blood samples were collected to determine plasma leptin, adiponectin, resistin, tumor necrosis factor alpha (TNFalpha), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP) and FFA concentrations. Plasma FFA, inflammatory marker (hsCRP, IL-6, TNFalpha), adipokine (adiponectin, resistin, leptin), and triglyceride concentrations did not differ between non-obese diabetes patients and healthy, normoglycemic controls. Plasma FFA, IL-6, hsCRP, leptin, and triglyceride levels were significantly higher in the obese diabetes patients when compared with the healthy normoglycemic controls (P < 0.05). Furthermore, plasma hsCRP and leptin levels were significantly higher in the obese versus non-obese diabetes patients (P < 0.05). Significant correlations between plasma parameters and glycemic control were observed, but disappeared after adjusting for trunk adipose tissue mass. Elevated plasma leptin, hsCRP, IL-6, and FFA concentrations are associated with obesity and not necessarily with the type 2 diabetic state.

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Plasma FFA, inflammatory marker and adipokine concentrations. Data are expressed as means ± SEM. *Significantly different between obese T2DM patients and other subgroups (P < 0.05). No significant differences were found between healthy subjects and non-obese T2DM patients (P > 0.05). Plasma leptin (a), adiponectin (b), resistin (c), free fatty acid (d), interleukin-6 (e), high-sensitivity C-reactive protein (f), and tumor necrosis factor α (g) concentrations
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Fig1: Plasma FFA, inflammatory marker and adipokine concentrations. Data are expressed as means ± SEM. *Significantly different between obese T2DM patients and other subgroups (P < 0.05). No significant differences were found between healthy subjects and non-obese T2DM patients (P > 0.05). Plasma leptin (a), adiponectin (b), resistin (c), free fatty acid (d), interleukin-6 (e), high-sensitivity C-reactive protein (f), and tumor necrosis factor α (g) concentrations

Mentions: Basal plasma adipokine (adiponectin, leptin, resistin), FFA, and inflammatory marker (hsCRP, IL-6) concentrations are presented in Fig. 1. No significant differences were observed between non-obese diabetes patients and normoglycemic controls (P > 0.05). Plasma FFA, IL-6, hsCRP, and leptin levels were significantly higher in obese diabetes patients when compared with normoglycemic controls (P < 0.05). Furthermore, plasma hsCRP and leptin levels were significantly elevated in obese versus non-obese diabetes patients (P < 0.05).Fig. 1


Plasma adipokine and inflammatory marker concentrations are altered in obese, as opposed to non-obese, type 2 diabetes patients.

Hansen D, Dendale P, Beelen M, Jonkers RA, Mullens A, Corluy L, Meeusen R, van Loon LJ - Eur. J. Appl. Physiol. (2010)

Plasma FFA, inflammatory marker and adipokine concentrations. Data are expressed as means ± SEM. *Significantly different between obese T2DM patients and other subgroups (P < 0.05). No significant differences were found between healthy subjects and non-obese T2DM patients (P > 0.05). Plasma leptin (a), adiponectin (b), resistin (c), free fatty acid (d), interleukin-6 (e), high-sensitivity C-reactive protein (f), and tumor necrosis factor α (g) concentrations
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2874484&req=5

Fig1: Plasma FFA, inflammatory marker and adipokine concentrations. Data are expressed as means ± SEM. *Significantly different between obese T2DM patients and other subgroups (P < 0.05). No significant differences were found between healthy subjects and non-obese T2DM patients (P > 0.05). Plasma leptin (a), adiponectin (b), resistin (c), free fatty acid (d), interleukin-6 (e), high-sensitivity C-reactive protein (f), and tumor necrosis factor α (g) concentrations
Mentions: Basal plasma adipokine (adiponectin, leptin, resistin), FFA, and inflammatory marker (hsCRP, IL-6) concentrations are presented in Fig. 1. No significant differences were observed between non-obese diabetes patients and normoglycemic controls (P > 0.05). Plasma FFA, IL-6, hsCRP, and leptin levels were significantly higher in obese diabetes patients when compared with normoglycemic controls (P < 0.05). Furthermore, plasma hsCRP and leptin levels were significantly elevated in obese versus non-obese diabetes patients (P < 0.05).Fig. 1

Bottom Line: Plasma FFA, inflammatory marker (hsCRP, IL-6, TNFalpha), adipokine (adiponectin, resistin, leptin), and triglyceride concentrations did not differ between non-obese diabetes patients and healthy, normoglycemic controls.Plasma FFA, IL-6, hsCRP, leptin, and triglyceride levels were significantly higher in the obese diabetes patients when compared with the healthy normoglycemic controls (P < 0.05).Furthermore, plasma hsCRP and leptin levels were significantly higher in the obese versus non-obese diabetes patients (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Human Physiology and Sportsmedicine, Vrije Universiteit Brussel (VUB), Brussels, Belgium. Hansen_dominique@yahoo.com

ABSTRACT
Elevated plasma free fatty acid (FFA), inflammatory marker, and altered adipokine concentrations have been observed in obese type 2 diabetes patients. It remains unclear whether these altered plasma concentrations are related to the diabetic state or presence of obesity. In this cross-sectional observational study, we compare basal plasma FFA, inflammatory marker, and adipokine concentrations between obese and non-obese type 2 diabetes patients and healthy, non-obese controls. A total of 20 healthy, normoglycemic males (BMI <30 kg/m(2)), 20 non-obese (BMI <30 kg/m(2)) and 20 obese (BMI >35 kg/m(2)) type 2 diabetes patients were selected to participate in this study. Groups were matched for age and habitual physical activity level. Body composition, glycemic control, and exercise performance capacity were assessed. Basal blood samples were collected to determine plasma leptin, adiponectin, resistin, tumor necrosis factor alpha (TNFalpha), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP) and FFA concentrations. Plasma FFA, inflammatory marker (hsCRP, IL-6, TNFalpha), adipokine (adiponectin, resistin, leptin), and triglyceride concentrations did not differ between non-obese diabetes patients and healthy, normoglycemic controls. Plasma FFA, IL-6, hsCRP, leptin, and triglyceride levels were significantly higher in the obese diabetes patients when compared with the healthy normoglycemic controls (P < 0.05). Furthermore, plasma hsCRP and leptin levels were significantly higher in the obese versus non-obese diabetes patients (P < 0.05). Significant correlations between plasma parameters and glycemic control were observed, but disappeared after adjusting for trunk adipose tissue mass. Elevated plasma leptin, hsCRP, IL-6, and FFA concentrations are associated with obesity and not necessarily with the type 2 diabetic state.

Show MeSH
Related in: MedlinePlus