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Resveratrol preserves cerebrovascular density and cognitive function in aging mice.

Oomen CA, Farkas E, Roman V, van der Beek EM, Luiten PG, Meerlo P - Front Aging Neurosci (2009)

Bottom Line: Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to exert numerous beneficial health effects.We found no effects of resveratrol supplementation on cholinergic cell number or fiber density.The present findings support the hypothesis that resveratrol exerts beneficial effects on the brain by maintaining cerebrovascular health.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Neurobiology, Center for Behavior and Neuroscience, University of Groningen Groningen, The Netherlands.

ABSTRACT
Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to exert numerous beneficial health effects. Among others, acute neuroprotective effects of resveratrol have been described in several models of neurodegeneration, both in vitro and in vivo. In the present study we examined the neuroprotective effects of long-term dietary supplementation with resveratrol in mice on behavioral, neurochemical and cerebrovascular level. We report a preserved cognitive function in resveratrol-treated aging mice, as shown by an enhanced acquisition of a spatial Y-maze task. This was paralleled by a higher microvascular density and a lower number of microvascular abnormalities in comparison to aging non-treated control animals. We found no effects of resveratrol supplementation on cholinergic cell number or fiber density. The present findings support the hypothesis that resveratrol exerts beneficial effects on the brain by maintaining cerebrovascular health. Via this mechanism resveratrol can contribute to the preservation of cognitive function during aging.

No MeSH data available.


Related in: MedlinePlus

Effects of chronic resveratrol supplementation on Y-maze learning. The Y-maze test consisted of 3 training days and a retention day 1 week later. Each day consisted of eight trials and the performance of the animals is expressed as the percentage of correct choices per day. RES animals (n = 28) show faster acquisition of the task then CON animals (n = 28), as shown on day 2 (*p = 0.016).
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Figure 2: Effects of chronic resveratrol supplementation on Y-maze learning. The Y-maze test consisted of 3 training days and a retention day 1 week later. Each day consisted of eight trials and the performance of the animals is expressed as the percentage of correct choices per day. RES animals (n = 28) show faster acquisition of the task then CON animals (n = 28), as shown on day 2 (*p = 0.016).

Mentions: Also during the habituation trial of the Y-maze, CON (n = 28) and RES (n = 28) mice displayed similar levels of activity in terms of arm visits and spontaneous alternations (data not shown). However, during the training phase, chronic resveratrol supplementation improved learning (repeated measures ANOVA for number of correct choices on day 1–3: F1,54 = 6.156, p = 0.016; Figure 2). A T-test per day showed that RES animals performed better than CON animals on the second day of the training phase (p < 0.05). The final level of performance on day 3 and the retention trial on day 10 were not different between CON and RES.


Resveratrol preserves cerebrovascular density and cognitive function in aging mice.

Oomen CA, Farkas E, Roman V, van der Beek EM, Luiten PG, Meerlo P - Front Aging Neurosci (2009)

Effects of chronic resveratrol supplementation on Y-maze learning. The Y-maze test consisted of 3 training days and a retention day 1 week later. Each day consisted of eight trials and the performance of the animals is expressed as the percentage of correct choices per day. RES animals (n = 28) show faster acquisition of the task then CON animals (n = 28), as shown on day 2 (*p = 0.016).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2874408&req=5

Figure 2: Effects of chronic resveratrol supplementation on Y-maze learning. The Y-maze test consisted of 3 training days and a retention day 1 week later. Each day consisted of eight trials and the performance of the animals is expressed as the percentage of correct choices per day. RES animals (n = 28) show faster acquisition of the task then CON animals (n = 28), as shown on day 2 (*p = 0.016).
Mentions: Also during the habituation trial of the Y-maze, CON (n = 28) and RES (n = 28) mice displayed similar levels of activity in terms of arm visits and spontaneous alternations (data not shown). However, during the training phase, chronic resveratrol supplementation improved learning (repeated measures ANOVA for number of correct choices on day 1–3: F1,54 = 6.156, p = 0.016; Figure 2). A T-test per day showed that RES animals performed better than CON animals on the second day of the training phase (p < 0.05). The final level of performance on day 3 and the retention trial on day 10 were not different between CON and RES.

Bottom Line: Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to exert numerous beneficial health effects.We found no effects of resveratrol supplementation on cholinergic cell number or fiber density.The present findings support the hypothesis that resveratrol exerts beneficial effects on the brain by maintaining cerebrovascular health.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Neurobiology, Center for Behavior and Neuroscience, University of Groningen Groningen, The Netherlands.

ABSTRACT
Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to exert numerous beneficial health effects. Among others, acute neuroprotective effects of resveratrol have been described in several models of neurodegeneration, both in vitro and in vivo. In the present study we examined the neuroprotective effects of long-term dietary supplementation with resveratrol in mice on behavioral, neurochemical and cerebrovascular level. We report a preserved cognitive function in resveratrol-treated aging mice, as shown by an enhanced acquisition of a spatial Y-maze task. This was paralleled by a higher microvascular density and a lower number of microvascular abnormalities in comparison to aging non-treated control animals. We found no effects of resveratrol supplementation on cholinergic cell number or fiber density. The present findings support the hypothesis that resveratrol exerts beneficial effects on the brain by maintaining cerebrovascular health. Via this mechanism resveratrol can contribute to the preservation of cognitive function during aging.

No MeSH data available.


Related in: MedlinePlus