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Resveratrol preserves cerebrovascular density and cognitive function in aging mice.

Oomen CA, Farkas E, Roman V, van der Beek EM, Luiten PG, Meerlo P - Front Aging Neurosci (2009)

Bottom Line: Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to exert numerous beneficial health effects.We found no effects of resveratrol supplementation on cholinergic cell number or fiber density.The present findings support the hypothesis that resveratrol exerts beneficial effects on the brain by maintaining cerebrovascular health.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Neurobiology, Center for Behavior and Neuroscience, University of Groningen Groningen, The Netherlands.

ABSTRACT
Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to exert numerous beneficial health effects. Among others, acute neuroprotective effects of resveratrol have been described in several models of neurodegeneration, both in vitro and in vivo. In the present study we examined the neuroprotective effects of long-term dietary supplementation with resveratrol in mice on behavioral, neurochemical and cerebrovascular level. We report a preserved cognitive function in resveratrol-treated aging mice, as shown by an enhanced acquisition of a spatial Y-maze task. This was paralleled by a higher microvascular density and a lower number of microvascular abnormalities in comparison to aging non-treated control animals. We found no effects of resveratrol supplementation on cholinergic cell number or fiber density. The present findings support the hypothesis that resveratrol exerts beneficial effects on the brain by maintaining cerebrovascular health. Via this mechanism resveratrol can contribute to the preservation of cognitive function during aging.

No MeSH data available.


Related in: MedlinePlus

Effects of chronic resveratrol supplementation on locomotor behavior in an open field. The test duration was 5 min and locomotion of CON (n = 28) and RES (n = 28) animals was monitored with an automated video analysis system. (A) Total distance covered during the test. (B) Time spent in the center area (diameter: 60 cm) of the arena (*p=0.003).
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Figure 1: Effects of chronic resveratrol supplementation on locomotor behavior in an open field. The test duration was 5 min and locomotion of CON (n = 28) and RES (n = 28) animals was monitored with an automated video analysis system. (A) Total distance covered during the test. (B) Time spent in the center area (diameter: 60 cm) of the arena (*p=0.003).

Mentions: In the open-field test, CON and RES mice displayed the same amount of locomotion (total distance covered), however, the RES group spent about 50% more time in the center of the arena than the control animals (T-test, p = 0.003; Figures 1A,B).


Resveratrol preserves cerebrovascular density and cognitive function in aging mice.

Oomen CA, Farkas E, Roman V, van der Beek EM, Luiten PG, Meerlo P - Front Aging Neurosci (2009)

Effects of chronic resveratrol supplementation on locomotor behavior in an open field. The test duration was 5 min and locomotion of CON (n = 28) and RES (n = 28) animals was monitored with an automated video analysis system. (A) Total distance covered during the test. (B) Time spent in the center area (diameter: 60 cm) of the arena (*p=0.003).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2874408&req=5

Figure 1: Effects of chronic resveratrol supplementation on locomotor behavior in an open field. The test duration was 5 min and locomotion of CON (n = 28) and RES (n = 28) animals was monitored with an automated video analysis system. (A) Total distance covered during the test. (B) Time spent in the center area (diameter: 60 cm) of the arena (*p=0.003).
Mentions: In the open-field test, CON and RES mice displayed the same amount of locomotion (total distance covered), however, the RES group spent about 50% more time in the center of the arena than the control animals (T-test, p = 0.003; Figures 1A,B).

Bottom Line: Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to exert numerous beneficial health effects.We found no effects of resveratrol supplementation on cholinergic cell number or fiber density.The present findings support the hypothesis that resveratrol exerts beneficial effects on the brain by maintaining cerebrovascular health.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Neurobiology, Center for Behavior and Neuroscience, University of Groningen Groningen, The Netherlands.

ABSTRACT
Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to exert numerous beneficial health effects. Among others, acute neuroprotective effects of resveratrol have been described in several models of neurodegeneration, both in vitro and in vivo. In the present study we examined the neuroprotective effects of long-term dietary supplementation with resveratrol in mice on behavioral, neurochemical and cerebrovascular level. We report a preserved cognitive function in resveratrol-treated aging mice, as shown by an enhanced acquisition of a spatial Y-maze task. This was paralleled by a higher microvascular density and a lower number of microvascular abnormalities in comparison to aging non-treated control animals. We found no effects of resveratrol supplementation on cholinergic cell number or fiber density. The present findings support the hypothesis that resveratrol exerts beneficial effects on the brain by maintaining cerebrovascular health. Via this mechanism resveratrol can contribute to the preservation of cognitive function during aging.

No MeSH data available.


Related in: MedlinePlus