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Detection of newly described astrovirus MLB1 in stool samples from children.

Bányai K, Meleg E, Moschidou P, Martella V - Emerging Infect. Dis. (2010)

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Neighbor-joining tree based on partial sequences of open reading frame 1a protein of human and animal astroviruses. Amino acid sequences of the Mexican M3363 strain (arrow) were obtained from Walter (4); other sequences were obtained from GenBank. Bootstrap values >90 are indicated. Scale bar is proportional to genetic distance and indicates nucleotide substitutions per site.
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Figure 1: Neighbor-joining tree based on partial sequences of open reading frame 1a protein of human and animal astroviruses. Amino acid sequences of the Mexican M3363 strain (arrow) were obtained from Walter (4); other sequences were obtained from GenBank. Bootstrap values >90 are indicated. Scale bar is proportional to genetic distance and indicates nucleotide substitutions per site.

Mentions: When we reanalyzed ORF1a of M3363, we found that this strain was actually an MLB1-like AstV with >98% amino acid similarity to prototype and strains from the United States (Figure) that dated back to 1991. The fact that such closely related viruses were found in a scattered temporal and spatial pattern in children may indicate that MLB1-like AstVs represent a true human enteric virus, which was probably overlooked in the absence of adequate diagnostic reagents and protocols.


Detection of newly described astrovirus MLB1 in stool samples from children.

Bányai K, Meleg E, Moschidou P, Martella V - Emerging Infect. Dis. (2010)

Neighbor-joining tree based on partial sequences of open reading frame 1a protein of human and animal astroviruses. Amino acid sequences of the Mexican M3363 strain (arrow) were obtained from Walter (4); other sequences were obtained from GenBank. Bootstrap values >90 are indicated. Scale bar is proportional to genetic distance and indicates nucleotide substitutions per site.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2874377&req=5

Figure 1: Neighbor-joining tree based on partial sequences of open reading frame 1a protein of human and animal astroviruses. Amino acid sequences of the Mexican M3363 strain (arrow) were obtained from Walter (4); other sequences were obtained from GenBank. Bootstrap values >90 are indicated. Scale bar is proportional to genetic distance and indicates nucleotide substitutions per site.
Mentions: When we reanalyzed ORF1a of M3363, we found that this strain was actually an MLB1-like AstV with >98% amino acid similarity to prototype and strains from the United States (Figure) that dated back to 1991. The fact that such closely related viruses were found in a scattered temporal and spatial pattern in children may indicate that MLB1-like AstVs represent a true human enteric virus, which was probably overlooked in the absence of adequate diagnostic reagents and protocols.

View Article: PubMed Central - PubMed

Show MeSH
Related in: MedlinePlus