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H. pylori-Eradication Therapy Increases RUNX3 Expression in the Glandular Epithelial Cells in Enlarged-Fold Gastritis.

Suzuki M, Suzuki H, Minegishi Y, Ito K, Nishizawa T, Hibi T - J Clin Biochem Nutr (2010)

Bottom Line: A fourfold higher mucosal ChL value was observed in the corpus as compared with that in the antrum.HP-eradication significantly decreased the mucosal ChL values in both portions of the stomach to nearly undetectable levels.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Division of Gastroenterology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan.

ABSTRACT
Helicobacter pylori (HP)-eradication therapy increases Runt domain transcription factor 3 (RUNX3) expression in the glandular epithelial cells in enlarged-fold gastritis. The aim of this study is to evaluate expression of the RUNX3 protein, the product of a gastric tumor suppression gene, and mutagenic oxidative stress in human gastric mucosal specimens obtained from patients with HP-induced enlarged-fold gastritis. Methods. RUNX3 expression was immunohistochemically scored and the degree of the mucosal oxidative stress was directly measured by the chemiluminescense (ChL) assay in the biopsy specimens. Results. RUNX3 expression was detected in the gastric epithelial cells. HP-eradication significantly increased RUNX3 expression in the glandular epithelium of the corpus, however, no change was observed in those of the antrum. A fourfold higher mucosal ChL value was observed in the corpus as compared with that in the antrum. HP-eradication significantly decreased the mucosal ChL values in both portions of the stomach to nearly undetectable levels. Conclusion. The glandular epithelium is exposed to a high level of carcinogenic oxidative stress and shows low levels of expression of the tumor suppressive molecule, RUNX3; however, this expression was restored after HP-eradication, suggesting the high risk of carcinogenesis associated with HP-induced enlarged-fold gastritis of the corpus.

No MeSH data available.


Related in: MedlinePlus

Endoscopic images before (A) and after (B) HP eradication in patients with enlarged-fold gastritis. HP eradication was followed by a reduction of the enlarged folds with thick mucus.
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Related In: Results  -  Collection


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Figure 1: Endoscopic images before (A) and after (B) HP eradication in patients with enlarged-fold gastritis. HP eradication was followed by a reduction of the enlarged folds with thick mucus.

Mentions: The characteristic endoscopic features of enlarged-fold gastritis are shown in Fig. 1. Before the HP eradication, enlarged folds with thick mucus were observed in the greater curvature at the corpus, which clearly improved after HP eradication therapy.


H. pylori-Eradication Therapy Increases RUNX3 Expression in the Glandular Epithelial Cells in Enlarged-Fold Gastritis.

Suzuki M, Suzuki H, Minegishi Y, Ito K, Nishizawa T, Hibi T - J Clin Biochem Nutr (2010)

Endoscopic images before (A) and after (B) HP eradication in patients with enlarged-fold gastritis. HP eradication was followed by a reduction of the enlarged folds with thick mucus.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2872232&req=5

Figure 1: Endoscopic images before (A) and after (B) HP eradication in patients with enlarged-fold gastritis. HP eradication was followed by a reduction of the enlarged folds with thick mucus.
Mentions: The characteristic endoscopic features of enlarged-fold gastritis are shown in Fig. 1. Before the HP eradication, enlarged folds with thick mucus were observed in the greater curvature at the corpus, which clearly improved after HP eradication therapy.

Bottom Line: A fourfold higher mucosal ChL value was observed in the corpus as compared with that in the antrum.HP-eradication significantly decreased the mucosal ChL values in both portions of the stomach to nearly undetectable levels.Conclusion.

View Article: PubMed Central - PubMed

Affiliation: Division of Gastroenterology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan.

ABSTRACT
Helicobacter pylori (HP)-eradication therapy increases Runt domain transcription factor 3 (RUNX3) expression in the glandular epithelial cells in enlarged-fold gastritis. The aim of this study is to evaluate expression of the RUNX3 protein, the product of a gastric tumor suppression gene, and mutagenic oxidative stress in human gastric mucosal specimens obtained from patients with HP-induced enlarged-fold gastritis. Methods. RUNX3 expression was immunohistochemically scored and the degree of the mucosal oxidative stress was directly measured by the chemiluminescense (ChL) assay in the biopsy specimens. Results. RUNX3 expression was detected in the gastric epithelial cells. HP-eradication significantly increased RUNX3 expression in the glandular epithelium of the corpus, however, no change was observed in those of the antrum. A fourfold higher mucosal ChL value was observed in the corpus as compared with that in the antrum. HP-eradication significantly decreased the mucosal ChL values in both portions of the stomach to nearly undetectable levels. Conclusion. The glandular epithelium is exposed to a high level of carcinogenic oxidative stress and shows low levels of expression of the tumor suppressive molecule, RUNX3; however, this expression was restored after HP-eradication, suggesting the high risk of carcinogenesis associated with HP-induced enlarged-fold gastritis of the corpus.

No MeSH data available.


Related in: MedlinePlus