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Eucalyptus leaf extract suppresses the postprandial elevation of portal, cardiac and peripheral fructose concentrations after sucrose ingestion in rats.

Sugimoto K, Hosotani T, Kawasaki T, Nakagawa K, Hayashi S, Nakano Y, Inui H, Yamanouchi T - J Clin Biochem Nutr (2010)

Bottom Line: This increase was significantly lower in the ELE group.ELE suppressed postprandial hyperfructosemia in the portal, cardiac, and peripheral circulations.ELE may counteract glycation caused by high blood fructose concentrations induced by the consumption of fructose-containing foods or drinks.

View Article: PubMed Central - PubMed

Affiliation: Research and Development Center, Nagaoka Perfumery Co. Ltd., 1-3-30 Itsukaichi, Ibaraki, Osaka 567-0005, Japan.

ABSTRACT
Overintake of sucrose or fructose induces adiposity. Fructose undergoes a strong Maillard reaction, which worsens diabetic complications. To determine whether Eucalyptus globulus leaf extract (ELE) suppresses the postprandial elevation of serum fructose concentrations (SFCs) in the portal, cardiac, and peripheral blood after sucrose ingestion, we performed gas chromatography/mass spectrometry (GC/MS) and measured SFC without any interference by contaminating glucose in the samples. Fasting Wistar rats were orally administered water (control group) or ELE (ELE group) before sucrose ingestion. Blood was collected from the portal vein, heart, and tail. The increase in the SFCs in the portal and cardiac samples 30 min after sucrose ingestion was lower in the ELE group than in the control group. The coefficient of correlation between the SFCs in the portal and cardiac samples was 0.825. The peripheral SFC in the control group progressively increased and was 146 micromol/L at 60 min. This increase was significantly lower in the ELE group. In contrast, the serum glucose concentrations in the 2 groups were similar. ELE suppressed postprandial hyperfructosemia in the portal, cardiac, and peripheral circulations. ELE may counteract glycation caused by high blood fructose concentrations induced by the consumption of fructose-containing foods or drinks.

No MeSH data available.


Related in: MedlinePlus

Eucalyptus leaf extract (ELE) significantly suppresses the postprandial elevation of the peripheral serum fructose concentration after the sucrose-tolerance test in rats (Study 2). The mean (SD) peripheral serum fructose concentrations in the control (open circles) and ELE (closed circles) groups are shown. Fasting rats (n = 10) were orally administered water (control group) or ELE at a dose of 1 g/kg body weight (ELE group) prior to the ingestion of sucrose (2 g/kg body weight). The fructose concentrations in the peripheral serum sampled from the tail were determined. *p<0.05 compared to the control group.
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Figure 3: Eucalyptus leaf extract (ELE) significantly suppresses the postprandial elevation of the peripheral serum fructose concentration after the sucrose-tolerance test in rats (Study 2). The mean (SD) peripheral serum fructose concentrations in the control (open circles) and ELE (closed circles) groups are shown. Fasting rats (n = 10) were orally administered water (control group) or ELE at a dose of 1 g/kg body weight (ELE group) prior to the ingestion of sucrose (2 g/kg body weight). The fructose concentrations in the peripheral serum sampled from the tail were determined. *p<0.05 compared to the control group.

Mentions: The time course of the peripheral SFCs during the sucrose-tolerance test is shown in Fig. 3. The fasting SFCs in the 2 groups almost equaled the SFC in the cardiac samples in Study 1 (approximately 20 µmol/L). After the sucrose load, the peripheral SFC in the control group progressively increased and reached 146 ± 29 µmol/L at 60 min. Although the peripheral SFCs in the ELE group also increased, the increment was significantly lower, and the inhibition ratios were 90% and 65% at 30 and 60 min, respectively (p<0.05).


Eucalyptus leaf extract suppresses the postprandial elevation of portal, cardiac and peripheral fructose concentrations after sucrose ingestion in rats.

Sugimoto K, Hosotani T, Kawasaki T, Nakagawa K, Hayashi S, Nakano Y, Inui H, Yamanouchi T - J Clin Biochem Nutr (2010)

Eucalyptus leaf extract (ELE) significantly suppresses the postprandial elevation of the peripheral serum fructose concentration after the sucrose-tolerance test in rats (Study 2). The mean (SD) peripheral serum fructose concentrations in the control (open circles) and ELE (closed circles) groups are shown. Fasting rats (n = 10) were orally administered water (control group) or ELE at a dose of 1 g/kg body weight (ELE group) prior to the ingestion of sucrose (2 g/kg body weight). The fructose concentrations in the peripheral serum sampled from the tail were determined. *p<0.05 compared to the control group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2872225&req=5

Figure 3: Eucalyptus leaf extract (ELE) significantly suppresses the postprandial elevation of the peripheral serum fructose concentration after the sucrose-tolerance test in rats (Study 2). The mean (SD) peripheral serum fructose concentrations in the control (open circles) and ELE (closed circles) groups are shown. Fasting rats (n = 10) were orally administered water (control group) or ELE at a dose of 1 g/kg body weight (ELE group) prior to the ingestion of sucrose (2 g/kg body weight). The fructose concentrations in the peripheral serum sampled from the tail were determined. *p<0.05 compared to the control group.
Mentions: The time course of the peripheral SFCs during the sucrose-tolerance test is shown in Fig. 3. The fasting SFCs in the 2 groups almost equaled the SFC in the cardiac samples in Study 1 (approximately 20 µmol/L). After the sucrose load, the peripheral SFC in the control group progressively increased and reached 146 ± 29 µmol/L at 60 min. Although the peripheral SFCs in the ELE group also increased, the increment was significantly lower, and the inhibition ratios were 90% and 65% at 30 and 60 min, respectively (p<0.05).

Bottom Line: This increase was significantly lower in the ELE group.ELE suppressed postprandial hyperfructosemia in the portal, cardiac, and peripheral circulations.ELE may counteract glycation caused by high blood fructose concentrations induced by the consumption of fructose-containing foods or drinks.

View Article: PubMed Central - PubMed

Affiliation: Research and Development Center, Nagaoka Perfumery Co. Ltd., 1-3-30 Itsukaichi, Ibaraki, Osaka 567-0005, Japan.

ABSTRACT
Overintake of sucrose or fructose induces adiposity. Fructose undergoes a strong Maillard reaction, which worsens diabetic complications. To determine whether Eucalyptus globulus leaf extract (ELE) suppresses the postprandial elevation of serum fructose concentrations (SFCs) in the portal, cardiac, and peripheral blood after sucrose ingestion, we performed gas chromatography/mass spectrometry (GC/MS) and measured SFC without any interference by contaminating glucose in the samples. Fasting Wistar rats were orally administered water (control group) or ELE (ELE group) before sucrose ingestion. Blood was collected from the portal vein, heart, and tail. The increase in the SFCs in the portal and cardiac samples 30 min after sucrose ingestion was lower in the ELE group than in the control group. The coefficient of correlation between the SFCs in the portal and cardiac samples was 0.825. The peripheral SFC in the control group progressively increased and was 146 micromol/L at 60 min. This increase was significantly lower in the ELE group. In contrast, the serum glucose concentrations in the 2 groups were similar. ELE suppressed postprandial hyperfructosemia in the portal, cardiac, and peripheral circulations. ELE may counteract glycation caused by high blood fructose concentrations induced by the consumption of fructose-containing foods or drinks.

No MeSH data available.


Related in: MedlinePlus