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Progression from chronic atrophic gastritis to gastric cancer; tangle, toggle, tackle with Korea red ginseng.

Kim YJ, Chung JW, Lee SJ, Choi KS, Kim JH, Hahm KB - J Clin Biochem Nutr (2010)

Bottom Line: Key molecular players that link inflammation to carcinogenesis are prostaglandins, cytokines, nuclear factor-kappaB (NF-kappaB), chemokines, angiogenic growth factors, and free radicals, all of which lead to increased mutations and altered functions of important enzymes and proteins, for example, activation of oncogenic products and/or inhibition of tumor suppressor proteins, in inflamed tissues, thus contributing to multi-stage carcinogenesis process.In this review, we discuss the possibilities for cancer prevention by controlling inflammation process in Helicobacter pylori (H. pylori)-associated inflamed stomach with Korea red ginseng.Korea red ginseng is a good example of a natural herb that has ubiquitous properties that are conductive to stop inflammatory carcinogenesis that is un wanted outcome of H. pylori infection, rendering rejuvenation of chronic atrophic gastritis.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology Gachon Graduate School of Medicine, 7-45 Songdo-dong, Yeonsu-gu, Incheon 406-840, Korea.

ABSTRACT
Key molecular players that link inflammation to carcinogenesis are prostaglandins, cytokines, nuclear factor-kappaB (NF-kappaB), chemokines, angiogenic growth factors, and free radicals, all of which lead to increased mutations and altered functions of important enzymes and proteins, for example, activation of oncogenic products and/or inhibition of tumor suppressor proteins, in inflamed tissues, thus contributing to multi-stage carcinogenesis process. Interpreted reversely, the identification of the molecular mechanisms by which chronic inflammation increases cancer risk or optimal intervention of targeted drugs or agents during the inflammation-associated carcinogenic process could be a necessary basis for developing new strategy of cancer prevention at many sites. In this review, we discuss the possibilities for cancer prevention by controlling inflammation process in Helicobacter pylori (H. pylori)-associated inflamed stomach with Korea red ginseng. Korea red ginseng is a good example of a natural herb that has ubiquitous properties that are conductive to stop inflammatory carcinogenesis that is un wanted outcome of H. pylori infection, rendering rejuvenation of chronic atrophic gastritis.

No MeSH data available.


Related in: MedlinePlus

Rejuvenation of atrophic gastritis with Korea red ginseng (A) Updated Sydney system to score the degree of gastric atrophy. Two examples of atrophic gastritis and intestinal metaplasia (B) Changes of gastric atrophy. OAC 1W stands for 1 week of triple therapy including omeprazole, amoxicillin and clarithromycin [48]. Simply successful eradication of H. pylori alone could led to improvement of gastric atrophy in around 30% of cases, but OAC 1W plus 10 weeks of Korea red ginseng supplementation resulted in statistically significantly increment in improvement of gastric atrophy (p<0.05), signifying that rejuvenation of gastric atrophy can be accelerated with Korea red ginseng supplementation after eradication regimen.
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Figure 3: Rejuvenation of atrophic gastritis with Korea red ginseng (A) Updated Sydney system to score the degree of gastric atrophy. Two examples of atrophic gastritis and intestinal metaplasia (B) Changes of gastric atrophy. OAC 1W stands for 1 week of triple therapy including omeprazole, amoxicillin and clarithromycin [48]. Simply successful eradication of H. pylori alone could led to improvement of gastric atrophy in around 30% of cases, but OAC 1W plus 10 weeks of Korea red ginseng supplementation resulted in statistically significantly increment in improvement of gastric atrophy (p<0.05), signifying that rejuvenation of gastric atrophy can be accelerated with Korea red ginseng supplementation after eradication regimen.

Mentions: As Korea red ginseng has been reported to show a significant protective effect against H. pylori-induced cytotoxicity and DNA damage in vitro, we designed a clinical study to assess the efficacy of red ginseng treatment in patients with H. pylori-associated chronic gastritis [48]. A total of 84 patients with H. pylori-associated chronic gastritis were recruited and randomly divided into two groups. During the trial, 34 patients out of 42 patients in the placebo control group and 36 patients out of 42 patients in the red ginseng group completed the protocol. The patients received a one week triple therapy for the eradication of H. pylori and then received either placebo capsules that were composed of flour for the placebo group or red ginseng capsules for the treatment group, which were administered for 10 weeks. An endoscopic examination of gastritis with a visual analogue scale, a test for detection of H. pylori, immunohistochemistry of 8-OHdG, the 8-OHdG immunohistochemical staining for assessing oxidative DNA damage and TUNEL staining for apoptosis were performed, respectively. As results, H. pylori eradication rates were augmented in the red ginseng group as compared to the placebo group (91.7% in the red ginseng group and 79.4% in the placebo group), but there was no statistical significance (p = 0.147). For an analysis of gastritis based on Updated Sydney System (Fig. 3A), the red ginseng group showed significant improvement in neutrophil infiltrations (p = 0.008), chronic atrophic gastritis (Fig. 3B, p<0.05), and even intestinal metaplasia (p = 0.005). An attenuation of 8-OHdG immunohistostaining after treatment was seen more frequently in the red ginseng group (p<0.001) (Fig. 4). An attenuation of DNA damage and apoptosis was seen for the red ginseng group as compared to the placebo group (p<0.001). Therefore, supplementary administration of red ginseng augmented eradication rates of H. pylori, attenuated gastric inflammation, and reduced oxidative DNA damage and apoptosis, suggesting the clinical usefulness of red ginseng.


Progression from chronic atrophic gastritis to gastric cancer; tangle, toggle, tackle with Korea red ginseng.

Kim YJ, Chung JW, Lee SJ, Choi KS, Kim JH, Hahm KB - J Clin Biochem Nutr (2010)

Rejuvenation of atrophic gastritis with Korea red ginseng (A) Updated Sydney system to score the degree of gastric atrophy. Two examples of atrophic gastritis and intestinal metaplasia (B) Changes of gastric atrophy. OAC 1W stands for 1 week of triple therapy including omeprazole, amoxicillin and clarithromycin [48]. Simply successful eradication of H. pylori alone could led to improvement of gastric atrophy in around 30% of cases, but OAC 1W plus 10 weeks of Korea red ginseng supplementation resulted in statistically significantly increment in improvement of gastric atrophy (p<0.05), signifying that rejuvenation of gastric atrophy can be accelerated with Korea red ginseng supplementation after eradication regimen.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2872224&req=5

Figure 3: Rejuvenation of atrophic gastritis with Korea red ginseng (A) Updated Sydney system to score the degree of gastric atrophy. Two examples of atrophic gastritis and intestinal metaplasia (B) Changes of gastric atrophy. OAC 1W stands for 1 week of triple therapy including omeprazole, amoxicillin and clarithromycin [48]. Simply successful eradication of H. pylori alone could led to improvement of gastric atrophy in around 30% of cases, but OAC 1W plus 10 weeks of Korea red ginseng supplementation resulted in statistically significantly increment in improvement of gastric atrophy (p<0.05), signifying that rejuvenation of gastric atrophy can be accelerated with Korea red ginseng supplementation after eradication regimen.
Mentions: As Korea red ginseng has been reported to show a significant protective effect against H. pylori-induced cytotoxicity and DNA damage in vitro, we designed a clinical study to assess the efficacy of red ginseng treatment in patients with H. pylori-associated chronic gastritis [48]. A total of 84 patients with H. pylori-associated chronic gastritis were recruited and randomly divided into two groups. During the trial, 34 patients out of 42 patients in the placebo control group and 36 patients out of 42 patients in the red ginseng group completed the protocol. The patients received a one week triple therapy for the eradication of H. pylori and then received either placebo capsules that were composed of flour for the placebo group or red ginseng capsules for the treatment group, which were administered for 10 weeks. An endoscopic examination of gastritis with a visual analogue scale, a test for detection of H. pylori, immunohistochemistry of 8-OHdG, the 8-OHdG immunohistochemical staining for assessing oxidative DNA damage and TUNEL staining for apoptosis were performed, respectively. As results, H. pylori eradication rates were augmented in the red ginseng group as compared to the placebo group (91.7% in the red ginseng group and 79.4% in the placebo group), but there was no statistical significance (p = 0.147). For an analysis of gastritis based on Updated Sydney System (Fig. 3A), the red ginseng group showed significant improvement in neutrophil infiltrations (p = 0.008), chronic atrophic gastritis (Fig. 3B, p<0.05), and even intestinal metaplasia (p = 0.005). An attenuation of 8-OHdG immunohistostaining after treatment was seen more frequently in the red ginseng group (p<0.001) (Fig. 4). An attenuation of DNA damage and apoptosis was seen for the red ginseng group as compared to the placebo group (p<0.001). Therefore, supplementary administration of red ginseng augmented eradication rates of H. pylori, attenuated gastric inflammation, and reduced oxidative DNA damage and apoptosis, suggesting the clinical usefulness of red ginseng.

Bottom Line: Key molecular players that link inflammation to carcinogenesis are prostaglandins, cytokines, nuclear factor-kappaB (NF-kappaB), chemokines, angiogenic growth factors, and free radicals, all of which lead to increased mutations and altered functions of important enzymes and proteins, for example, activation of oncogenic products and/or inhibition of tumor suppressor proteins, in inflamed tissues, thus contributing to multi-stage carcinogenesis process.In this review, we discuss the possibilities for cancer prevention by controlling inflammation process in Helicobacter pylori (H. pylori)-associated inflamed stomach with Korea red ginseng.Korea red ginseng is a good example of a natural herb that has ubiquitous properties that are conductive to stop inflammatory carcinogenesis that is un wanted outcome of H. pylori infection, rendering rejuvenation of chronic atrophic gastritis.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology Gachon Graduate School of Medicine, 7-45 Songdo-dong, Yeonsu-gu, Incheon 406-840, Korea.

ABSTRACT
Key molecular players that link inflammation to carcinogenesis are prostaglandins, cytokines, nuclear factor-kappaB (NF-kappaB), chemokines, angiogenic growth factors, and free radicals, all of which lead to increased mutations and altered functions of important enzymes and proteins, for example, activation of oncogenic products and/or inhibition of tumor suppressor proteins, in inflamed tissues, thus contributing to multi-stage carcinogenesis process. Interpreted reversely, the identification of the molecular mechanisms by which chronic inflammation increases cancer risk or optimal intervention of targeted drugs or agents during the inflammation-associated carcinogenic process could be a necessary basis for developing new strategy of cancer prevention at many sites. In this review, we discuss the possibilities for cancer prevention by controlling inflammation process in Helicobacter pylori (H. pylori)-associated inflamed stomach with Korea red ginseng. Korea red ginseng is a good example of a natural herb that has ubiquitous properties that are conductive to stop inflammatory carcinogenesis that is un wanted outcome of H. pylori infection, rendering rejuvenation of chronic atrophic gastritis.

No MeSH data available.


Related in: MedlinePlus