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Progression from chronic atrophic gastritis to gastric cancer; tangle, toggle, tackle with Korea red ginseng.

Kim YJ, Chung JW, Lee SJ, Choi KS, Kim JH, Hahm KB - J Clin Biochem Nutr (2010)

Bottom Line: Key molecular players that link inflammation to carcinogenesis are prostaglandins, cytokines, nuclear factor-kappaB (NF-kappaB), chemokines, angiogenic growth factors, and free radicals, all of which lead to increased mutations and altered functions of important enzymes and proteins, for example, activation of oncogenic products and/or inhibition of tumor suppressor proteins, in inflamed tissues, thus contributing to multi-stage carcinogenesis process.In this review, we discuss the possibilities for cancer prevention by controlling inflammation process in Helicobacter pylori (H. pylori)-associated inflamed stomach with Korea red ginseng.Korea red ginseng is a good example of a natural herb that has ubiquitous properties that are conductive to stop inflammatory carcinogenesis that is un wanted outcome of H. pylori infection, rendering rejuvenation of chronic atrophic gastritis.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology Gachon Graduate School of Medicine, 7-45 Songdo-dong, Yeonsu-gu, Incheon 406-840, Korea.

ABSTRACT
Key molecular players that link inflammation to carcinogenesis are prostaglandins, cytokines, nuclear factor-kappaB (NF-kappaB), chemokines, angiogenic growth factors, and free radicals, all of which lead to increased mutations and altered functions of important enzymes and proteins, for example, activation of oncogenic products and/or inhibition of tumor suppressor proteins, in inflamed tissues, thus contributing to multi-stage carcinogenesis process. Interpreted reversely, the identification of the molecular mechanisms by which chronic inflammation increases cancer risk or optimal intervention of targeted drugs or agents during the inflammation-associated carcinogenic process could be a necessary basis for developing new strategy of cancer prevention at many sites. In this review, we discuss the possibilities for cancer prevention by controlling inflammation process in Helicobacter pylori (H. pylori)-associated inflamed stomach with Korea red ginseng. Korea red ginseng is a good example of a natural herb that has ubiquitous properties that are conductive to stop inflammatory carcinogenesis that is un wanted outcome of H. pylori infection, rendering rejuvenation of chronic atrophic gastritis.

No MeSH data available.


Related in: MedlinePlus

(A) Rescuing effects of Korea red ginseng against H. pylori-induced inflammation or cytotoxicity [46] Red ginseng could block several pathways to H. pylori-associated gastric damages including the connection between inflammation and carcinogenesis. They can block signal transduction pathway to inflammatory signals, attenuate apoptosis execution, and repress redox sensitive transcriptional activation. (B) Inhibitory activities and attenuated expression of 5-LOX with red ginseng in H. pylori-infected gastric epithelial cells [47]. Besides of COX-2 activation after H. pylori infection, H. pylori infection triggered 5-LOX activation, leading to increased production of 5(S)-HETE. Red ginseng showed efficient blockade to 5-LOX activation as equivalently efficient to 5-LOX inhibitors, geraniin.
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Figure 2: (A) Rescuing effects of Korea red ginseng against H. pylori-induced inflammation or cytotoxicity [46] Red ginseng could block several pathways to H. pylori-associated gastric damages including the connection between inflammation and carcinogenesis. They can block signal transduction pathway to inflammatory signals, attenuate apoptosis execution, and repress redox sensitive transcriptional activation. (B) Inhibitory activities and attenuated expression of 5-LOX with red ginseng in H. pylori-infected gastric epithelial cells [47]. Besides of COX-2 activation after H. pylori infection, H. pylori infection triggered 5-LOX activation, leading to increased production of 5(S)-HETE. Red ginseng showed efficient blockade to 5-LOX activation as equivalently efficient to 5-LOX inhibitors, geraniin.

Mentions: First, we documented that Korea red ginseng could rescue H. pylori-induced cytotoxicity [46]. In addition to rescuing actions of Korea red ginseng, they mitigate the oxidative stress-induced DNA mutation. Red ginseng extracts significantly attenuated both H. pylori-induced DNA damage assessed by comet assay, apoptosis measured by DNA fragmentation, and expressions of 8-OH-dG (Fig. 1B) for which inactivation of ERK1/2 signal transduction and attenuation of caspase-3 activation were operated. Simutaneously, Korea red ginseng decreased the H. pylori-stimulated IL-8 expression, suggesting that based on these gastroprotective effects of ginseng against H. pylori-associated gastric mucosal damages, red ginseng could be used as a medicinal phytonutrient against H. pylori infection (Fig. 2A).


Progression from chronic atrophic gastritis to gastric cancer; tangle, toggle, tackle with Korea red ginseng.

Kim YJ, Chung JW, Lee SJ, Choi KS, Kim JH, Hahm KB - J Clin Biochem Nutr (2010)

(A) Rescuing effects of Korea red ginseng against H. pylori-induced inflammation or cytotoxicity [46] Red ginseng could block several pathways to H. pylori-associated gastric damages including the connection between inflammation and carcinogenesis. They can block signal transduction pathway to inflammatory signals, attenuate apoptosis execution, and repress redox sensitive transcriptional activation. (B) Inhibitory activities and attenuated expression of 5-LOX with red ginseng in H. pylori-infected gastric epithelial cells [47]. Besides of COX-2 activation after H. pylori infection, H. pylori infection triggered 5-LOX activation, leading to increased production of 5(S)-HETE. Red ginseng showed efficient blockade to 5-LOX activation as equivalently efficient to 5-LOX inhibitors, geraniin.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2872224&req=5

Figure 2: (A) Rescuing effects of Korea red ginseng against H. pylori-induced inflammation or cytotoxicity [46] Red ginseng could block several pathways to H. pylori-associated gastric damages including the connection between inflammation and carcinogenesis. They can block signal transduction pathway to inflammatory signals, attenuate apoptosis execution, and repress redox sensitive transcriptional activation. (B) Inhibitory activities and attenuated expression of 5-LOX with red ginseng in H. pylori-infected gastric epithelial cells [47]. Besides of COX-2 activation after H. pylori infection, H. pylori infection triggered 5-LOX activation, leading to increased production of 5(S)-HETE. Red ginseng showed efficient blockade to 5-LOX activation as equivalently efficient to 5-LOX inhibitors, geraniin.
Mentions: First, we documented that Korea red ginseng could rescue H. pylori-induced cytotoxicity [46]. In addition to rescuing actions of Korea red ginseng, they mitigate the oxidative stress-induced DNA mutation. Red ginseng extracts significantly attenuated both H. pylori-induced DNA damage assessed by comet assay, apoptosis measured by DNA fragmentation, and expressions of 8-OH-dG (Fig. 1B) for which inactivation of ERK1/2 signal transduction and attenuation of caspase-3 activation were operated. Simutaneously, Korea red ginseng decreased the H. pylori-stimulated IL-8 expression, suggesting that based on these gastroprotective effects of ginseng against H. pylori-associated gastric mucosal damages, red ginseng could be used as a medicinal phytonutrient against H. pylori infection (Fig. 2A).

Bottom Line: Key molecular players that link inflammation to carcinogenesis are prostaglandins, cytokines, nuclear factor-kappaB (NF-kappaB), chemokines, angiogenic growth factors, and free radicals, all of which lead to increased mutations and altered functions of important enzymes and proteins, for example, activation of oncogenic products and/or inhibition of tumor suppressor proteins, in inflamed tissues, thus contributing to multi-stage carcinogenesis process.In this review, we discuss the possibilities for cancer prevention by controlling inflammation process in Helicobacter pylori (H. pylori)-associated inflamed stomach with Korea red ginseng.Korea red ginseng is a good example of a natural herb that has ubiquitous properties that are conductive to stop inflammatory carcinogenesis that is un wanted outcome of H. pylori infection, rendering rejuvenation of chronic atrophic gastritis.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology Gachon Graduate School of Medicine, 7-45 Songdo-dong, Yeonsu-gu, Incheon 406-840, Korea.

ABSTRACT
Key molecular players that link inflammation to carcinogenesis are prostaglandins, cytokines, nuclear factor-kappaB (NF-kappaB), chemokines, angiogenic growth factors, and free radicals, all of which lead to increased mutations and altered functions of important enzymes and proteins, for example, activation of oncogenic products and/or inhibition of tumor suppressor proteins, in inflamed tissues, thus contributing to multi-stage carcinogenesis process. Interpreted reversely, the identification of the molecular mechanisms by which chronic inflammation increases cancer risk or optimal intervention of targeted drugs or agents during the inflammation-associated carcinogenic process could be a necessary basis for developing new strategy of cancer prevention at many sites. In this review, we discuss the possibilities for cancer prevention by controlling inflammation process in Helicobacter pylori (H. pylori)-associated inflamed stomach with Korea red ginseng. Korea red ginseng is a good example of a natural herb that has ubiquitous properties that are conductive to stop inflammatory carcinogenesis that is un wanted outcome of H. pylori infection, rendering rejuvenation of chronic atrophic gastritis.

No MeSH data available.


Related in: MedlinePlus