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ArteFill permanent injectable for soft tissue augmentation: I. Mechanism of action and injection techniques.

Lemperle G, Knapp TR, Sadick NS, Lemperle SM - Aesthetic Plast Surg (2009)

Bottom Line: No serious side effects have been reported to date according to the FDA's MAUDE reporting database.The standard injection technique is subdermal tunneling that delivers a strand of ArteFill at the dermal-subdermal junction.This strand beneath a wrinkle or fold acts like a support structure that protects against further wrinkling and allows the diminished thickness of the dermis to recover to its original thickness.

View Article: PubMed Central - PubMed

Affiliation: Division of Plastic Surgery, University of California, San Diego, 200 West Arbor Drive, San Diego, CA 92103, USA. glemperle@aol.com

ABSTRACT
After more than 25 years of research and development, in October 2006 ArteFill became the first and only permanent injectable wrinkle filler to receive FDA approval. ArteFill is a third-generation polymeric microsphere-based filler, following its predecessor Artecoll, which was marketed outside the United States between 1994 and 2006. ArteFill is approved for the correction of nasolabial folds and has been used in over 15,000 patients since its U.S. market introduction in February 2007. No serious side effects have been reported to date according to the FDA's MAUDE reporting database. ArteFill consists of polymethylmethacrylate (PMMA) microspheres (20% by volume), 30-50 microm in diameter, suspended in 3.5% bovine collagen solution (80% by volume) and 0.3% lidocaine. The collagen carrier is absorbed within 1 month after injection and completely replaced by the patient's own connective tissue within 3 months. Each cc of ArteFill contains approximately six million microspheres and histological studies have shown that long-term wrinkle correction consists of 80% of the patient's own connective tissue and 20% microspheres. The standard injection technique is subdermal tunneling that delivers a strand of ArteFill at the dermal-subdermal junction. This strand beneath a wrinkle or fold acts like a support structure that protects against further wrinkling and allows the diminished thickness of the dermis to recover to its original thickness.

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For the first few weeks the viscous collagen keeps the microspheres apart to facilitate tissue ingrowth
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Fig2: For the first few weeks the viscous collagen keeps the microspheres apart to facilitate tissue ingrowth

Mentions: The third reaction to foreign material is the formation of “granulation tissue,” composed of macrophages, fibroblasts, capillaries, and collagen that fill the interstitial spaces between the microspheres. The bovine collagen [1, 2] appears to maintain the separation between the microspheres and facilitates tissue ingrowth (Fig. 2). Without ArteFill’s collagen component the microspheres would clump together—a phenomenon observed in other filler formulations using hyaluronic acid-based or methylcellulose carriers [9].Fig. 2


ArteFill permanent injectable for soft tissue augmentation: I. Mechanism of action and injection techniques.

Lemperle G, Knapp TR, Sadick NS, Lemperle SM - Aesthetic Plast Surg (2009)

For the first few weeks the viscous collagen keeps the microspheres apart to facilitate tissue ingrowth
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2872009&req=5

Fig2: For the first few weeks the viscous collagen keeps the microspheres apart to facilitate tissue ingrowth
Mentions: The third reaction to foreign material is the formation of “granulation tissue,” composed of macrophages, fibroblasts, capillaries, and collagen that fill the interstitial spaces between the microspheres. The bovine collagen [1, 2] appears to maintain the separation between the microspheres and facilitates tissue ingrowth (Fig. 2). Without ArteFill’s collagen component the microspheres would clump together—a phenomenon observed in other filler formulations using hyaluronic acid-based or methylcellulose carriers [9].Fig. 2

Bottom Line: No serious side effects have been reported to date according to the FDA's MAUDE reporting database.The standard injection technique is subdermal tunneling that delivers a strand of ArteFill at the dermal-subdermal junction.This strand beneath a wrinkle or fold acts like a support structure that protects against further wrinkling and allows the diminished thickness of the dermis to recover to its original thickness.

View Article: PubMed Central - PubMed

Affiliation: Division of Plastic Surgery, University of California, San Diego, 200 West Arbor Drive, San Diego, CA 92103, USA. glemperle@aol.com

ABSTRACT
After more than 25 years of research and development, in October 2006 ArteFill became the first and only permanent injectable wrinkle filler to receive FDA approval. ArteFill is a third-generation polymeric microsphere-based filler, following its predecessor Artecoll, which was marketed outside the United States between 1994 and 2006. ArteFill is approved for the correction of nasolabial folds and has been used in over 15,000 patients since its U.S. market introduction in February 2007. No serious side effects have been reported to date according to the FDA's MAUDE reporting database. ArteFill consists of polymethylmethacrylate (PMMA) microspheres (20% by volume), 30-50 microm in diameter, suspended in 3.5% bovine collagen solution (80% by volume) and 0.3% lidocaine. The collagen carrier is absorbed within 1 month after injection and completely replaced by the patient's own connective tissue within 3 months. Each cc of ArteFill contains approximately six million microspheres and histological studies have shown that long-term wrinkle correction consists of 80% of the patient's own connective tissue and 20% microspheres. The standard injection technique is subdermal tunneling that delivers a strand of ArteFill at the dermal-subdermal junction. This strand beneath a wrinkle or fold acts like a support structure that protects against further wrinkling and allows the diminished thickness of the dermis to recover to its original thickness.

Show MeSH