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ArteFill permanent injectable for soft tissue augmentation: II. Indications and applications.

Lemperle G, Sadick NS, Knapp TR, Lemperle SM - Aesthetic Plast Surg (2009)

Bottom Line: Patients ask for procedures with long-lasting effects.Over the development period of 20 years most of its side effects have been eliminated to achieve the same safety standard as today's hyaluronic acid products.Patient and physician satisfaction with ArteFill has been shown to be greater than 90%.

View Article: PubMed Central - PubMed

Affiliation: Division of Plastic Surgery, University of California, San Diego, 200 West Arbor Drive, San Diego, CA 92103, USA. glemperle@aol.com

ABSTRACT
Patients ask for procedures with long-lasting effects. ArteFill is the first permanent injectable approved in 2006 by the FDA for nasolabial folds. It consists of cleaned microspheres of polymethylmethacrylate (PMMA) suspended in bovine collagen. Over the development period of 20 years most of its side effects have been eliminated to achieve the same safety standard as today's hyaluronic acid products. A 5-year follow-up study in U.S. clinical trial patients has shown the same wrinkle improvement as seen at 6 months. Long-term follow-up in European Artecoll patients has shown successful wrinkle correction lasting up to 15 years. A wide variety of off-label indications and applications have been developed that help the physician meet the individual needs of his/her patients. Serious complications after ArteFill injections, such as granuloma formation, have not been reported due to the reduction of PMMA microspheres smaller than 20 microm to less than 1% "by the number." Minor technique-related side effects, however, may occur during the initial learning curve. Patient and physician satisfaction with ArteFill has been shown to be greater than 90%.

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Related in: MedlinePlus

Horizontal neck folds in a young patient
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Fig29: Horizontal neck folds in a young patient

Mentions: The dermis of the neck is extremely thin. Therefore, a 2-cm-long test implantation to avoid overcorrection is a good idea. Implantation results are favorable in the young patient, but a second treatment often is required (Figs. 29 and 30). An aged and flaccid neck is a contraindication for ArteFill. Patients with dark skin must know that underlying hyperpigmentation in the folds can be more obvious after augmentation.Fig. 29


ArteFill permanent injectable for soft tissue augmentation: II. Indications and applications.

Lemperle G, Sadick NS, Knapp TR, Lemperle SM - Aesthetic Plast Surg (2009)

Horizontal neck folds in a young patient
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2872008&req=5

Fig29: Horizontal neck folds in a young patient
Mentions: The dermis of the neck is extremely thin. Therefore, a 2-cm-long test implantation to avoid overcorrection is a good idea. Implantation results are favorable in the young patient, but a second treatment often is required (Figs. 29 and 30). An aged and flaccid neck is a contraindication for ArteFill. Patients with dark skin must know that underlying hyperpigmentation in the folds can be more obvious after augmentation.Fig. 29

Bottom Line: Patients ask for procedures with long-lasting effects.Over the development period of 20 years most of its side effects have been eliminated to achieve the same safety standard as today's hyaluronic acid products.Patient and physician satisfaction with ArteFill has been shown to be greater than 90%.

View Article: PubMed Central - PubMed

Affiliation: Division of Plastic Surgery, University of California, San Diego, 200 West Arbor Drive, San Diego, CA 92103, USA. glemperle@aol.com

ABSTRACT
Patients ask for procedures with long-lasting effects. ArteFill is the first permanent injectable approved in 2006 by the FDA for nasolabial folds. It consists of cleaned microspheres of polymethylmethacrylate (PMMA) suspended in bovine collagen. Over the development period of 20 years most of its side effects have been eliminated to achieve the same safety standard as today's hyaluronic acid products. A 5-year follow-up study in U.S. clinical trial patients has shown the same wrinkle improvement as seen at 6 months. Long-term follow-up in European Artecoll patients has shown successful wrinkle correction lasting up to 15 years. A wide variety of off-label indications and applications have been developed that help the physician meet the individual needs of his/her patients. Serious complications after ArteFill injections, such as granuloma formation, have not been reported due to the reduction of PMMA microspheres smaller than 20 microm to less than 1% "by the number." Minor technique-related side effects, however, may occur during the initial learning curve. Patient and physician satisfaction with ArteFill has been shown to be greater than 90%.

Show MeSH
Related in: MedlinePlus